Acid and light stimuli-responsive mesoporous silica nanoparticles for controlled release

Wang, Mingdong; Wang, Ting; Wang, Dong; Jiang, Wei; Fu, Jiajun

doi:10.1007/s10853-019-03325-x

Cited by 46 publications

(23 citation statements)

References 56 publications

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“…The pore of MSNs was capped with α-cyclodextrin with hydrazone bond linking the azobenzene functionalized MSNs and α-cyclodextrin. Through UV irradiation, the azobenzene conformation changed, which led to the dissociation of α-cyclodextrin and the drug, doxorubicin, released [ 188 ]. Although this work showed promising results, UV light as a trigger is not practical as it poses an adverse effect on the cell and tissue and has low tissue penetrability [ 200 ].…”

Section: Msns As Smart Drug Delivery Agentmentioning

confidence: 99%

Progress in Mesoporous Silica Nanoparticles as Drug Delivery Agents for Cancer Treatment

et al. 2021

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Cancer treatment and therapy have made significant leaps and bounds in these past decades. However, there are still cases where surgical removal is impossible, metastases are challenging, and chemotherapy and radiotherapy pose severe side effects. Therefore, a need to find more effective and specific treatments still exists. One way is through the utilization of drug delivery agents (DDA) based on nanomaterials. In 2001, mesoporous silica nanoparticles (MSNs) were first used as DDA and have gained considerable attention in this field. The popularity of MSNs is due to their unique properties such as tunable particle and pore size, high surface area and pore volume, easy functionalization and surface modification, high stability and their capability to efficiently entrap cargo molecules. This review describes the latest advancement of MSNs as DDA for cancer treatment. We focus on the fabrication of MSNs, the challenges in DDA development and how MSNs address the problems through the development of smart DDA using MSNs. Besides that, MSNs have also been applied as a multifunctional DDA where they can serve in both the diagnostic and treatment of cancer. Overall, we argue MSNs provide a bright future for both the diagnosis and treatment of cancer.

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Section: Msns As Smart Drug Delivery Agentmentioning

confidence: 99%

Progress in Mesoporous Silica Nanoparticles as Drug Delivery Agents for Cancer Treatment

et al. 2021

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“…For instance, using a cinnamamide derivative as stalk for cucurbit [7]uril allows to open and close the mesopores when irradiated with 300 nm and 254 UV-light, respectively [369]. Azobenzene derivatives show similar behavior, and can be employed as stalks for α- [370] and β-CDs [371] that only allow the drug release upon 365 nm UV-light irradiation. Similarly, azobenzene groups can be introduced as pendant groups throughout a polymer chain.…”

Section: Light-induced Conformational Changesmentioning

confidence: 99%

Influence of the Surface Functionalization on the Fate and Performance of Mesoporous Silica Nanoparticles

Gisbert-Garzarán

Vallet‐Regí

2020

Nanomaterials

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Mesoporous silica nanoparticles have been broadly applied as drug delivery systems owing to their exquisite features, such as excellent textural properties or biocompatibility. However, there are various biological barriers that prevent their proper translation into the clinic, including: (1) lack of selectivity toward tumor tissues, (2) lack of selectivity for tumoral cells and (3) endosomal sequestration of the particles upon internalization. In addition, their open porous structure may lead to premature drug release, consequently affecting healthy tissues and decreasing the efficacy of the treatment. First, this review will provide a comprehensive and systematic overview of the different approximations that have been implemented into mesoporous silica nanoparticles to overcome each of such biological barriers. Afterward, the potential premature and non-specific drug release from these mesoporous nanocarriers will be addressed by introducing the concept of stimuli-responsive gatekeepers, which endow the particles with on-demand and localized drug delivery.

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“…Moreover, these synthesized structures can undergo surface modifications, possess excellent biocompatibility and high pore volume [ 13 , 14 ]. Numerous research reports have indicated that MSNs can also be modified to be stimuli-responsive controlled release systems, which rapidly release drugs in response to changes in microenvironments of pathological sites or intracellular stimuli [ 15 – 18 ]. Among these stimuli-responsive systems, the pH-responsive system is of particular interest [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

pH-dependent delivery of chlorhexidine from PGA grafted mesoporous silica nanoparticles at resin-dentin interface

et al. 2021

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Background A low pH environment is created due to the production of acids by oral biofilms that further leads to the dissolution of hydroxyapatite crystal in the tooth structure significantly altering the equilibrium. Although the overall bacterial counts may not be eradicated from the oral cavity, however, synthesis of engineered anti-bacterial materials are warranted to reduce the pathogenic impact of the oral biofilms. The purpose of this study was to synthesize and characterize chlorhexidine (CHX)-loaded mesoporous silica nanoparticles (MSN) grafted with poly-L-glycolic acid (PGA) and to test the in vitro drug release in various pH environments, cytotoxicity, and antimicrobial capacity. In addition, this study aimed to investigate the delivery of CHX-loaded/MSN-PGA nanoparticles through demineralized dentin tubules and how these nanoparticles interact with tooth dentin after mixing with commercial dentin adhesive for potential clinical application. Results Characterization using SEM/TEM and EDX confirmed the synthesis of CHX-loaded/MSN-PGA. An increase in the percentage of drug encapsulation efficiency from 81 to 85% in CHX loaded/MSN and 92–95% in CHX loaded/MSN-PGA proportionately increased with increasing the amount of CHX during the fabrication of nanoparticles. For both time-periods (24 h or 30 days), the relative microbial viability significantly decreased by increasing the CHX content (P < 0.001). Generally, the cell viability percentage of DPSCs exposed to MSN-PGA/Blank, CHX-loaded/MSN, and CHX-loaded/MSN-PGA, respectively was > 80% indicating low cytotoxicity profiles of experimental nanoparticles. After 9 months in artificial saliva (pH 7.4), the significantly highest micro-tensile bond strength value was recorded for 25:50 CHX/MSN and 25:50:50 CHX/MSN-PGA. A homogenous and widely distributed 50:50:50 CHX-loaded/MSN-PGA nanoparticles exhibited excellent bonding with the application of commercially available dentin adhesive. Conclusions A pH-sensitive CHX release response was noted when loaded in MSN grafted PGA nanoparticles. The formulated drug-loaded nanocarrier demonstrated excellent physicochemical, spectral, and biological characteristics. Showing considerable capacity to penetrate effectively inside dentinal tubules and having high antibacterial efficacy, this system could be potentially used in adhesive and restorative dentistry.

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Acid and light stimuli-responsive mesoporous silica nanoparticles for controlled release

Cited by 46 publications

References 56 publications

Progress in Mesoporous Silica Nanoparticles as Drug Delivery Agents for Cancer Treatment

Progress in Mesoporous Silica Nanoparticles as Drug Delivery Agents for Cancer Treatment

Influence of the Surface Functionalization on the Fate and Performance of Mesoporous Silica Nanoparticles

pH-dependent delivery of chlorhexidine from PGA grafted mesoporous silica nanoparticles at resin-dentin interface

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