Acid and reduction dually cleavable amphiphilic comb-like copolymer micelles for controlled drug delivery

Shao, Wei; Miao, Ke; Liu, Huanhuan; Ye, Chunnuan; Du, Jianzhong; Zhao, Youliang

doi:10.1039/c3py00252g

Cited by 40 publications

(39 citation statements)

References 82 publications

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“…Acid‐ and reduction‐dual‐responsive comb‐like copolymer micelles and covalent shell cross‐linked micelles were also reported by Shao et al. and Hu et al., respectively 39. 40 In all of these studies, responsive micelles were implemented for in vitro encapsulation and release of the DOX chemotherapeutic drug.…”

Section: Dual‐stimuli Responsivenessmentioning

confidence: 75%

Multi‐Stimuli‐Responsive Polymeric Materials

Guragain

Bastakoti

Malgras

et al. 2015

Chemistry A European J

202

114

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Stimuli-responsive materials are of immense importance because of their ability to undergo alteration of their properties in response to their environment. The properties of such materials can be tuned by subtle adjustments in temperature, pH, light, and so forth. Among such smart materials, multi-stimuli-responsive polymeric materials are of pronounced significance as they offer a wide range of applications and their properties can be tuned through several mechanisms. Here, we aim to highlight some recent studies showcasing the multi-stimuli-responsive character of these polymers, which are still relatively little known compared to their single-stimuli-responsive counterpart.

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Section: Dual‐stimuli Responsivenessmentioning

confidence: 75%

Multi‐Stimuli‐Responsive Polymeric Materials

Guragain

Bastakoti

Malgras

et al. 2015

Chemistry A European J

202

114

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“…On the basis of the former idea, the second generation of BCMs were further customized with the ability to release their payload under certain variables of the site where release should occur. Those variables could be the physicochemical peculiarities of the body site (internal stimuli) as pH and temperature changes, the presence of counterions and enzymes, or redox potential; alternatively, the changes could be externally induced (external stimuli) through the application of, for example, light, ultrasound, or magnetic fields . Stimuli‐responsive micelles can be prepared with block copolymers that can undergo changes in their solvent affinity, conformation, or bonds under a given stimulus that changes their equilibrium association state or by the incorporation of sensitive external elements (e.g., gold or magnetite nanoparticles) that can recognize the stimulus; this leads to local perturbations that trigger micelle disassembly .…”

Section: Polymeric Micelles As Drug Nanocarriersmentioning

confidence: 99%

“…The most common example of this type of polymers is PNIPAAm, which, when used as the hydrophilic block, leads to micelles at temperatures below LCST (ca. 32°C) . Above LCST, the micelle destabilizes, and the loaded drug can be released.…”

Section: Polymeric Micelles As Drug Nanocarriersmentioning

confidence: 99%

Intelligent micellar polymeric nanocarriers for therapeutics and diagnosis

Topete

Barbosa

Taboada

2015

J of Applied Polymer Sci

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Polymeric micelles can be designed and synthesized to bear polymeric blocks with different hydrophilicities; this triggers their self-assembly into micellar aggregates similar to those generated with traditional surfactants. The basic structure consists of a hydrophobic core, capable of containing guest substances, and a hydrophilic shell, which stabilizes the payload and protects it from external degradation or prevents its quick elimination from the body. The accumulation of block copolymer micelles (BCMs) in a target cell or tissue can be accomplished by two main mechanisms, passive and active targeting; this allows the payload release at the site of action when desired. Hence, in this general overview, we pay special attention to newly developed single-stimulus-and multistimuli-responsive delivery systems capable of disassembling and reassembling (in some cases) as a response to changes in their physicochemical properties. Also, special interest is also devoted to multifunctional BCMs incorporating multiple therapeutic agents and/or multiple imaging contrast agents, which can be considered the new generation (third generation) of drug-delivery systems, that is, nanotheranostic platforms. Finally, a summary of BCM-based drug-delivery systems currently under clinical trials is given.

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“…Drug-loaded PU micelles have been designed to response to pH (Kumari et al., 2010) or reducing conditions (H. Kim et al., 2011; Shao et al., 2013), and enzyme (Cerritelli et al., 2007) environment of tumor cells (Kausar, 2017). Lu et al.…”

Section: Introductionmentioning

confidence: 99%

pH and reduction dual-responsive micelles based on novel polyurethanes with detachable poly(2-ethyl-2-oxazoline) shell for controlled release of doxorubicin

Zhang

et al. 2019

Drug Delivery

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We describe a biodegradable amphiphilic polyurethane (PU) with disulfide bonds in the main chain [PEtOz- b -PU(SS)- b -PEtOz]. This multi-block PU was synthesized using poly (ε-caprolactone) diol (PCL-SS-PCL) and poly (2-ethyl-2-oxazoline) (PEtOz-OH) as soft segments, and bis (2-isocyanatoethyl) disulfide as the hard segment. Acid-sensitive PEtOz-OH was used as a hydrophilic segment for pH sensitivity. And reduction sensitivity was induced via disulfide bonds incorporated into the hydrophobic poly (ε-caprolactone) segment of the amphiphilic PUs. The system can self-assemble to form micelles responsive to pH and reducing conditions. The properties of the micelle were studied with dynamic light scattering and scanning electron microscopy. Doxorubicin (DOX) was chosen as a model drug. The in vitro release studies showed that PEtOz- b -PU(SS)- b -PEtOz micelle could degrade more rapidly and completely in a reductive and acidic environment [10 mM dl -Dithiothreitol, pH 5.0]. The methyl tetrazolium (MTT) assay and fluorescent microscopy confirmed the cytotoxicity of the DOX-loaded micelles. This work provides a promising dual-responsive drug carrier based on amphiphilic PU to achieve efficient drug delivery.

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Acid and reduction dually cleavable amphiphilic comb-like copolymer micelles for controlled drug delivery

Cited by 40 publications

References 82 publications

Multi‐Stimuli‐Responsive Polymeric Materials

Multi‐Stimuli‐Responsive Polymeric Materials

Intelligent micellar polymeric nanocarriers for therapeutics and diagnosis

pH and reduction dual-responsive micelles based on novel polyurethanes with detachable poly(2-ethyl-2-oxazoline) shell for controlled release of doxorubicin

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