Acid-base balance in women with jaundice in late pregnancy

Alpha‐hydroxybutyrate dehydrogenase activity in intrahepatic cholestasis of pregnancy

“…In the present study, a high α‐HBDH activity was observed in the course of ICP. The excessive amount of this enzyme in the serum was probably of hepatic origin and could be the result of injury to the cytoplasm of hepatocytes caused by cholestasis [11–15].…”

“…However, this complication of pregnancy (an hemoglobin serum concentration of 8 mg/dL throughout pregnancy and the postpartum period) did not adversely influence perinatal outcome [23,24]. Intrahepatic cholestasis of pregnancy is associated with numerous metabolic disturbances that create unfavorable intrauterine environment for fetal development [1,[10][11][12][13][14][15][16][17]. The considerable increase in serum a-HBDH activity observed in this study is another metabolic abnormality present in ICP [11][12][13][14][15].…”

“…Intrahepatic cholestasis of pregnancy is associated with numerous metabolic disturbances that create unfavorable intrauterine environment for fetal development [1,[10][11][12][13][14][15][16][17]. The considerable increase in serum a-HBDH activity observed in this study is another metabolic abnormality present in ICP [11][12][13][14][15]. Routine evaluation of the activity of this enzyme may be of diagnostic value, as its activity is related to bilirubin concentration and alkaline phosphatase activity.…”

“…These changes are accompanied by mild metabolic acidosis [14], impaired erythrocyte metabolism [15], decreased serum selenium concentration, and decreased serum activity of glutathione peroxidase [16]. Intrahepatic cholestasis of pregnancy disturbs hepatocyte function, which is predominantly reflected by conjugated hyperbilirubinemia and increased alanine and aspartate aminotransferase activity [10][11][12][13][14].…”

“…Women with ICP have impaired renal glomerule and tubule function [11], disturbed carbohydrate metabolism [12], hyperlipidemia, hypocysteinemia, and an increased serum concentration of total estrogens, human placental lactogen, progesterone, estradiol, cortisol, free triiodothyronine, and free thyroxine [13]. These changes are accompanied by mild metabolic acidosis [14], impaired erythrocyte metabolism [15], decreased serum selenium concentration, and decreased serum activity of glutathione peroxidase [16]. Intrahepatic cholestasis of pregnancy disturbs hepatocyte function, which is predominantly reflected by conjugated hyperbilirubinemia and increased alanine and aspartate aminotransferase activity [10][11][12][13][14].…”