Acid-Base Changes in Arterial Blood Associated With Spontaneous and Controlled Ventilation During Anaesthesia

Millar, R.A.; Marshall, Barbara; Powell, Debra

doi:10.1093/bja/37.7.492

Cited by 9 publications

(3 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Indeed, after 30 minutes the average Pco 5 value was significantly lower than pre-operatively. This is contrary to the findings of Millar and Marshall (1965) whose patients returned slowly to normal during the first two or three postoperative hours. This may be because none of our patients had received postoperative medication at the time of the third sampling.…”

Section: Discussioncontrasting

confidence: 99%

A Study of Carbon Dioxide Tensions During Halothane Anaesthesia Using the Magill Circuit

Ivanov

Waddy

Jennings

1967

British Journal of Anaesthesia

View full text Add to dashboard Cite

In thirteen patients capillary blood samples were obtained for measurement of pH and Pco a immediately after the induction dose of thiopentone, after 45 minutes of 2 per cent halothane breathed spontaneously (with nitrous oxide and oxygen), and 30 minutes postoperatively. A very variable rise in Pco 2 was observed which did not correlate well with changes in pulse rate, blood pressure, respiratory frequency, respiratory minute volume, or with the age of the patient. A single measurement of respiratory minute volume with a Wright respirometer was of no value in indicating which patients had the greatest carbon dioxide retention. The return of Pco, to normal values in the postoperative period was found to be rapid and, for practical purposes, complete in 30 minutes.

show abstract

Section: Discussioncontrasting

confidence: 99%

A Study of Carbon Dioxide Tensions During Halothane Anaesthesia Using the Magill Circuit

Ivanov

Waddy

Jennings

1967

British Journal of Anaesthesia

View full text Add to dashboard Cite

show abstract

“…Some idea of the carbon dioxide titration curve during anaesthesia in man during hyperventilation can be made from data collected in the studies by Robinson (1960), Papadopoulos and Keats (1959), and more recently by Millar and Marshall (1965). Our analysis of Robinson's data showed a series of log Paoon/pH lines having a mean slope of -1.28.…”

Section: Discussionmentioning

confidence: 90%

“…This is unlikely to represent a metabolic acidosis unless their subjects had a mean haemoglobin concentration of more than 16 gm/100 ml. The findings of Millar and Marshall (1965) are difficult to interpret owing to the wide scatter of values, calculated from their data, for the slope of consecutive in vitro lines in the same patient.…”

Section: Discussionmentioning

confidence: 99%

Determination of the in Vivo Carbon Dioxide Tttration Curve of Anaesthetized Man

Prys‐Roberts

Kelman

Nunn

1966

British Journal of Anaesthesia

View full text Add to dashboard Cite

A comparison has been made between the pH changes in the arterial blood of anaesthetized patients exposed to changes of Pco, above and below the normal range, and those in the same blood equilibrated with similar changes of Pco, in vitro. Changes in the non-respiratory component as represented by standard bicarbonate, were derived from the in vitro equilibrations. There was a linear relationship between log Paooi and pH, and between pH and the plasma bicarbonate concentration, over the whole range studied in vivo. In the presence of wide variations of carbon dioxide tension, nitrous oxide anaesthesia of more than 2 hours duration, supplemented with a muscle relaxant and a potent analgesic, did not produce any significant alteration of the non-respiratory component of acid-base balance. Although changes of standard bicarbonate occurred in response to alterations of Pace these changes are not considered to represent true changes of the non-respiratory component. The application of parameters derived from in vitro equilibrations, to the behaviour of arterial blood in vivo is discussed. The mechanisms of extravascular buffering of induced changes of Pco, are reviewed, and related to the behaviour of arterial blood in equilibrium with extracellular and intracellular tissue fluids.

show abstract

Respiratory System

Munson¹

1972

Modern Inhalation Anesthetics

View full text Add to dashboard Cite

Acid-Base Changes in Arterial Blood Associated With Spontaneous and Controlled Ventilation During Anaesthesia

Cited by 9 publications

References 11 publications

A Study of Carbon Dioxide Tensions During Halothane Anaesthesia Using the Magill Circuit

A Study of Carbon Dioxide Tensions During Halothane Anaesthesia Using the Magill Circuit

Determination of the in Vivo Carbon Dioxide Tttration Curve of Anaesthetized Man

Respiratory System

Contact Info

Product

Resources

About