Acid-catalysed dimerisation of a 7-hydroxyindene

Abstract

Treatment of a 7-hydroxyindan-1 -one (2) with methyl magnesium iodide gives the corresponding tertiary alcohol and two pentacyclic dimers, (9a) and (9b).

An Alternative Convenient Synthesis of Piperidazine-3-carboxylic Acid Derivatives

“…Both of its enantiomeric forms have been encountered in many pharmacologically active molecules that include the azinothricin family of antitumor antibiotics, 1) verucopeptin, 2) the aurantimycins, 3) the C5a antagonist L-156,602, 4) the immunosuppressant IC101, 5) the oxytocin antagonist L-156,373, 6) and the matylastantin type-IV collagenase inhibitors. [7][8][9] There are several reports [10][11][12][13] about the synthesis of the racemic Piz. However, these reports have indicated some obstacles still to be overcome; the aza Diels-Alder (DA) reaction for the construction of the pyridazine framework has a low yield, and the N-deprotection was done under strict basic conditions.…”