Acid-catalyzed N-alkylation of tosylhydrazones using benzylic alcohols

Direct Substitution of Hydroxy Group of π-Activated Alcohols with Electron-Deficient Amines Using Re2O7 Catalyst

“…On the other hand, the protocols with electron-deficient nitrogen nucleophiles have been developed using various Lewis acids − or Brønsted acids. , However, besides the advantages, most of these catalysts are not broadly applicable to all classes (namely, allyl, benzyl, and propargyl) of π-activated alcohols . Additionally, in many cases, the reaction using such acids is restricted to aromatic amines only , or disubstituted amines are used to avoid overalkylation.…”

Synthesis of New Racemic α,α-Diaminocarboxylic Ester Derivatives

“…Diaminoacids are important non-protein amino acids, usually components of both natural and synthetic bioactive compounds [ 38 ]. In fact, they are currently well recognized as key structural moieties in a variety of biologically active molecules [ 39 , 40 ].…”

Access to 2,3‐Disubstituted Benzofurans through One‐Pot Acid‐Catalyzed Nucleophilic Substitution/TBAF‐Mediated Oxacycloisomerization

“…Our recent studies have also been focused in this direction for the synthesis of heterocyclic compounds 8. For instance, C 3 ‐alkylation of 4‐hydroxycoumarin to give furanocoumarins,8a through N ‐alkylation of tosylhydrazones towards pyrazoles,8b alkylation of 1,3‐dicarbonyl compounds for various oxygenated heterocycles,8c and O ‐alkylation of hydroximides to 2,5‐dihydroisoxazoles,8d have been successfully demonstrated. In a continuation of this work, we were prompted to explore the use of propargylic alcohols for the synthesis of 2,3‐disubstituted benzofurans.…”