Acid, nonacid, and gas reflux in patients with gastroesophageal reflux disease during ambulatory 24-hour pH-impedance recordings

Sifrim, Daniel; Holloway, Richard H.; Silny, Jiri; Zhang, Xin; Tack, Jan; Lerut, Antoon; Janssens, Jules

doi:10.1053/gast.2001.24841

Cited by 382 publications

(300 citation statements)

References 59 publications

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“…In our study, we were not able to find a direct association between the number of reflux episodes detected by either the technique of frame acquisition or the gastric emptying rate, regardless of age and refluxate level. These findings are consistent with prior reports showing no association between GOR and gastric emptying [10,[13][14][15][16], suggesting that delayed gastric emptying is not a major factor in the pathophysiology of GOR.…”

Section: Discussionsupporting

confidence: 93%

“…Following GOR scintigraphy acquisition at 5-s and 60-s frame rates, all data were analysed using SPSS® v. 16.0 (SPSS Inc., Chicago, IL), StatsDirect v. 2.7.9 (StatsDirect Ltd, Altrincham, UK) and Microsoft Office Excel 2003 (Redmond, WA). Continuous variables were expressed as the mean 6 standard error of the mean and tested for normal distribution.…”

Section: Discussionmentioning

confidence: 99%

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Effects of the frame acquisition rate on the sensitivity of gastro-oesophageal reflux scintigraphy

Codreanu

Chamroonrat²,

Edwards³

et al. 2013

BJR

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Objective: To compare the sensitivity of gastro-oesophageal reflux (GOR) scintigraphy at 5-s and 60-s frame acquisition rates.Methods: GOR scintigraphy of 50 subjects (1 month-20 years old, mean 42 months) were analysed concurrently using 5-s and 60-s acquisition frames. Reflux episodes were graded as low if activity was detected in the distal half of the oesophagus and high if activity was detected in its upper half or in the oral cavity. For comparison purposes, detected GOR in any number of 5-s frames corresponding to one 60-s frame was counted as one episode.Results: A total of 679 episodes of GOR to the upper oesophagus were counted using a 5-s acquisition technique. Only 183 of such episodes were detected on 60-s acquisition images. To the lower oesophagus, a total of 1749 GOR episodes were detected using a 5-s acquisition technique and only 1045 episodes using 60-s acquisition frames (these also included the high-level GOR on 5-s frames counted as low level on 60-s acquisition frames). 10 patients had high-level GOR episodes that were detected only using a 5-s acquisition technique, leading to a different diagnosis in these patients. No correlation between the number of reflux episodes and the gastric emptying rates was noted. Conclusion:The 5-s frame acquisition technique is more sensitive than the 60-s frame acquisition technique for detecting both highand low-level GOR. Advances in knowledge:Brief GOR episodes with a relatively low number of radioactive counts are frequently indistinguishable from intense background activity on 60-s acquisition frames.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Effects of the frame acquisition rate on the sensitivity of gastro-oesophageal reflux scintigraphy

Codreanu

Chamroonrat²,

Edwards³

et al. 2013

BJR

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“…33 A SI ≥ 50% was considered as positive, which was calculated in terms of acid reflux related, weakly acid reflux related, and alkaline reflux related, respectively. 34 The subjects with AET < 4.2%, no abnormal reflux, and SI < 50% were considered as FH. 35 …”

Section: Esophageal Multichannel Intraluminal Impedance and Ph Monitomentioning

confidence: 99%

Esophageal Body Motility for Clinical Assessment in Patients with Refractory Gastroesophageal Reflux Symptoms

Jiang

Wang

et al. 2017

J Neurogastroenterol Motil

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Background/AimsLittle data exists about esophageal body dysmotility and reflux patterns in refractory gastroesophageal reflux disease (RGERD) patients off therapy. We aimed to evaluate effects of esophageal body dysmotility on reflux parameters in RGERD patients by combining impedance-pH monitoring and high-resolution manometry (HRM). MethodsWe retrospectively reviewed the impedance-pH data and HRM metrics in patients with refractory gastroesophageal reflux symptoms. Impedance-pH monitoring and manometric data were compared between 2 groups: ineffective esophageal motility (IEM) and normal motility. ResultsForty-eight patients (30 males, mean age 54.5 years) were included (16 erosive esophagitis, 24 non-erosive reflux disease, and 8 functional heartburn), amongst which 24 subjects showed IEM, and others had normal motility. Number of patients who had a large break in the IEM group was significantly higher than that of normal motility patients. IEM group had more patients with weakly acid reflux and long term acid reflux than the normal group (P = 0.008, P = 0.004, respectively). There was no statistical difference in baseine impedance levels from z4 to z6 between the 2 groups (2911 ± 1160 Ω vs 3604 ± 1232 Ω, 2766 ± 1254 Ω vs 3752 ± 1439 Ω, 2349 ± 1131 Ω vs 3038 ± 1254 Ω, all P > 0.05). Acid exposure time, numbers of long term acid reflux and weakly acid reflux showed strong negative correlation with esophageal body motility and/or lower esophageal sphincter function. ConclusionsIEM was associated more with acid exposure, abnormal weakly acid reflux, and long term acid reflux in RGERD patients. These data suggested the role of esophageal body dysmotility in the pathophysiological mechanisms of RGERD patients.

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“…The use of combined Impedance-pH monitoring, thus increases the diagnostic yield compared to pH monitoring alone and is considered to be the most sensitive tool for assessing all types of GER (acidic, weakly acidic and weakly alkaline). 10,11 This study was conducted to determine the effect of laparoscopic cholecystectomy on GER (acid/ non-acid reflux) using impedance -pH monitoring.…”

Section: Tropical Gastroenterology 2014;35(4):222-226mentioning

confidence: 99%

Evaluation of gastroesophageal reflux after laparoscopic cholecystectomy using combined impedance-pH monitoring

Gupta

2014

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Acid, nonacid, and gas reflux in patients with gastroesophageal reflux disease during ambulatory 24-hour pH-impedance recordings

Cited by 382 publications

References 59 publications

Effects of the frame acquisition rate on the sensitivity of gastro-oesophageal reflux scintigraphy

Effects of the frame acquisition rate on the sensitivity of gastro-oesophageal reflux scintigraphy

Esophageal Body Motility for Clinical Assessment in Patients with Refractory Gastroesophageal Reflux Symptoms

Evaluation of gastroesophageal reflux after laparoscopic cholecystectomy using combined impedance-pH monitoring

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