Acid‐Sensitive Nanogels for Synergistic Chemo‐Photodynamic Therapy

Chen, Xiaofei; Yao, Xuemei; Chen, Li; Chen, Xuesi

doi:10.1002/mabi.201500180

Cited by 13 publications

(8 citation statements)

References 43 publications

(71 reference statements)

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“…On the basis of the above four mechanisms (ROS-promoted intracellular drug delivery, ROS-controlled/accelerated drug release, PDT-enhanced EPR effect of nanocarriers, and PDT-induced hypoxia for activation of bioreductive drug), the synergistic interactions between PDT and chemotherapy with multiple kinds of PS/drug coloaded nanostructures have been employed to substantially improve the ROS/drug cokilling functionality, − which results in pronounced tumor growth suppression and even regression.…”

Section: Nanotechnology For Bimodal Synergistic Therapymentioning

confidence: 99%

Nanotechnology for Multimodal Synergistic Cancer Therapy

et al. 2017

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The complexity, diversity, and heterogeneity of tumors seriously undermine the therapeutic potential of treatment. Therefore, the current trend in clinical research has gradually shifted from a focus on monotherapy to combination therapy for enhanced treatment efficacy. More importantly, the cooperative enhancement interactions between several types of monotherapy contribute to the naissance of multimodal synergistic therapy, which results in remarkable superadditive (namely "1 + 1 > 2") effects, stronger than any single therapy or their theoretical combination. In this review, state-of-the-art studies concerning recent advances in nanotechnology-mediated multimodal synergistic therapy will be systematically discussed, with an emphasis on the construction of multifunctional nanomaterials for realizing bimodal and trimodal synergistic therapy as well as the intensive exploration of the underlying synergistic mechanisms for explaining the significant improvements in synergistic therapeutic outcome. Furthermore, the featured applications of multimodal synergistic therapy in overcoming tumor multidrug resistance, hypoxia, and metastasis will also be discussed in detail, which may provide new ways for the efficient regression and even elimination of drug resistant, hypoxic solid, or distant metastatic tumors. Finally, some design tips for multifunctional nanomaterials and an outlook on the future development of multimodal synergistic therapy will be provided, highlighting key scientific issues and technical challenges and requiring remediation to accelerate clinical translation.

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Section: Nanotechnology For Bimodal Synergistic Therapymentioning

confidence: 99%

Nanotechnology for Multimodal Synergistic Cancer Therapy

et al. 2017

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“…Apart from the biodistribution, activation of PSs is another keypoint [132,133]. Although the PS can escape from the carrier and recover its activation after the biodegradation of polymer nanocarriers, stimuli responsive drug delivery systems are preferred [134,135,136,137,138,139].…”

Section: Administration Of Pssmentioning

confidence: 99%

Functional Polymer Nanocarriers for Photodynamic Therapy

Yan

2018

Pharmaceuticals

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Photodynamic therapy (PDT) is an appealing therapeutic modality in management of some solid tumors and other diseases for its minimal invasion and non-systemic toxicity. However, the hydrophobicity and non-selectivity of the photosensitizers, inherent serious hypoxia of tumor tissues and limited penetration depth of light restrict PDT further applications in clinic. Functional polymer nanoparticles can be used as a nanocarrier for accurate PDT. Here, we elucidate the mechanism and application of PDT in cancer treatments, and then review some strategies to administer the biodistribution and activation of photosensitizers (PSs) to ameliorate or utilize the tumor hypoxic microenvironment to enhance the photodynamic therapy effect.

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“…By using this prominent information, numerous chemotherapeutic strategies were developed involving a pH-dependent conjugation approach. − Concomitantly, novel multifunctional carriers also offer combinatorial therapies with this approach. In a related study, Chen et al designed a novel kind of intelligent nanogels that can spatiotemporally control the release of doxorubicin and photosensitizers to combine chemotherapy and photodynamic therapy …”

Section: Introductionmentioning

confidence: 99%

Poly(methacrylic acid)-Coated Gold Nanoparticles: Functional Platforms for Theranostic Applications

et al. 2016

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The integration of drugs with nanomaterials have received significant interest in the efficient drug delivery systems. Conventional treatments with therapeutically active drugs may cause undesired side effects and, thus, novel strategies to perform these treatments with a combinatorial approach of therapeutic modalities are required. In this study, polymethacrylic acid coated gold nanoparticles (AuNP-PMAA), which were synthesized with reversible addition-fragmentation chain transfer (RAFT) polymerization, were combined with doxorubicin (DOX) as a model anticancer drug by creating a pH-sensitive hydrazone linkage in the presence of cysteine (Cys) and a cross-linker. Drug-AuNP conjugates were characterized via spectrofluorimetry, dynamic light scattering and zeta potential measurements as well as X-ray photoelectron spectroscopy. The particle size of AuNP-PMAA and AuNP-PMAA-Cys-DOX conjugate were calculated as found as 104 and 147 nm, respectively. Further experiments with different pH conditions (pH 5.3 and 7.4) also showed that AuNP-PMAA-Cys-DOX conjugate could release the DOX in a pH-sensitive way. Finally, cell culture applications with human cervix adenocarcinoma cell line (HeLa cells) demonstrated effective therapeutic impact of the final conjugate for both chemotherapy and radiation therapy by comparing free DOX and AuNP-PMAA independently. Moreover, cell imaging study was also an evidence that AuNP-PMAA-Cys-DOX could be a beneficial candidate as a diagnostic agent.

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Acid‐Sensitive Nanogels for Synergistic Chemo‐Photodynamic Therapy

Cited by 13 publications

References 43 publications

Nanotechnology for Multimodal Synergistic Cancer Therapy

Nanotechnology for Multimodal Synergistic Cancer Therapy

Functional Polymer Nanocarriers for Photodynamic Therapy

Poly(methacrylic acid)-Coated Gold Nanoparticles: Functional Platforms for Theranostic Applications

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