Acid steatocrit determination is not helpful in cystic fibrosis patients without or with mild steatorrhea

Walkowiak, Jarosław; Lisowska, Aleksandra; Blask-Osipa, Anna; Drzymała-Czyz, Sławomira; Sobkowiak, Paulina; Cichy, Wojciech; Bręborowicz, Anna; Herzig, Karl‐Heinz; Radzikowski, Andrzej

doi:10.1002/ppul.21149

Cited by 7 publications

(4 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Qualitative fecal fat ("spot fecal fat") is not recommended due to its lack of specificity since a high fat intake in a normal patient can lead to a false positive result and diets rich in calcium can lead to increased fecal fat excretion [24]. The acid steatocrit has similar limitations and was shown to be less accurate than fecal fat excretion studies [25].…”

Section: Indirect Testsmentioning

confidence: 99%

Pancreatic insufficiency in Cystic Fibrosis

Singh

Schwarzenberg

2017

Journal of Cystic Fibrosis

154

View full text Add to dashboard Cite

show abstract

Section: Indirect Testsmentioning

confidence: 99%

Pancreatic insufficiency in Cystic Fibrosis

Singh

Schwarzenberg

2017

Journal of Cystic Fibrosis

154

View full text Add to dashboard Cite

show abstract

“…In our study, 65% of infants aged 1 to 3 months had FFC higher (median 6.3%) than normal values proposed by other groups (<5% for children). On the other hand, FFE in this group was higher than 4 g/day only in 2 children, while the applied cutoff level refers to subjects older than 2 years (1,15). It should be noted that the available data, however, are remarkably insufficient and contradictory.…”

Section: Discussionmentioning

confidence: 94%

Fecal Fat Concentration and Excretion in the First 2 Years of Life

Wieczorek-Filipiak¹,

Drzymała-Czyż²,

Szczepanik³

et al. 2019

J. pediatr. gastroenterol. nutr.

Self Cite

View full text Add to dashboard Cite

Objectives: Data on pancreatic exocrine secretion in the youngest children are scarce. The aim of the study was to determine the range of normal values for fecal fat concentration (FFC) and fecal fat excretion (FFE) in infants and toddlers up to 2 years of age. Methods: A total of 160 subjects aged 1 to 24 months (8 groups of 20: aged 1–3, 4–6 months, etc) were included in the study. In all children, FFC (%) and FFE (g/day) were assessed in 3-day stool collection. Results: FFC correlated with age (r = −0.50, P < 0.0001). Of infants aged 1 to 3 months 65% had FFC higher than the <5% norm proposed for older children. The values of 90th/95th FFC percentile ranged from 9.7/13.0% at 1 month to 3.1/3.2% at 24 months. FFE did not differ between age groups. It was, however, higher than 4 and 3 g/day in 7.5% and 15.0% infants, respectively. The first detailed nomogram for the assessment of FFC and FFE in children aged 1 to 24 months was created. Conclusions: Healthy infants may have higher FFC and FFE than older children. We provide reference values, which should allow for both precise and facile FFC and FFE interpretation in clinical practice.

show abstract

“…6 In contrast, Wagner et al 50 did not find a strong correlation between AS and CFA. Walkowiak and colleagues 51 studied the use of AS compared with fecal fat excretion (the inverse of CFA) in pwCF being treated with PERT and concluded that its applicability in the assessment of fecal fat content in this subgroup of patients has limited practical value; this article is an excellent review of the AS literature.…”

Section: Sparse Stoolmentioning

confidence: 99%

Coefficient of Fat Absorption to Measure the Efficacy of Pancreatic Enzyme Replacement Therapy in People With Cystic Fibrosis

et al. 2022

View full text Add to dashboard Cite

Objectives: We sought data on the validity, reliability, responsiveness, and feasibility of the coefficient of fat absorption (CFA) as a measure of pancreatic enzyme replacement therapy (PERT) efficacy in people with cystic fibrosis (pwCF) and reviewed the literature for alternative measures. Methods:We searched PubMed for the Medical Subject Heading cystic fibrosis and the key words cystic fibrosis, fat absorption, CFA, and fecal fat imbalance; historical articles; and citations in bibliographies. Results:The lower the CFA, the greater its variability; thus, it is less variable in healthy individuals who have higher CFA than pwCF. In addition, the test-retest values for CFA are more variable in pwCF than the general population. There is no correlation between CFA and body mass index or PERT dose but CFA is related to gastrointestinal signs and symptoms. Research-quality CFA studies are expensive, time consuming, and odious to pwCF and research staff. Sparse stool tests, breath tests, and blood tests of fat absorption have been studied as potential alternatives to CFA to measure PERT efficacy.Conclusions: Based on the evidence, we conclude that CFA as a measure of the efficacy of PERT is more of a "coal standard" than a gold standard; developing suitable alternatives should be a priority.

show abstract

Acid steatocrit determination is not helpful in cystic fibrosis patients without or with mild steatorrhea

Abstract: AS does not reflect in a reliable way FFE in CF patients without or mild steatorrhea. Its applicability in the assessment of FFC in such patients has therefore limited practical value.

Cited by 7 publications

References 20 publications

Pancreatic insufficiency in Cystic Fibrosis

Pancreatic insufficiency in Cystic Fibrosis

Fecal Fat Concentration and Excretion in the First 2 Years of Life

Coefficient of Fat Absorption to Measure the Efficacy of Pancreatic Enzyme Replacement Therapy in People With Cystic Fibrosis

Contact Info

Product

Resources

About