Soil is a finite natural resource and is indispensable for human civilization because it is the medium for food production for the biosphere. Continued soil degradation is a forerunner of catastrophe for the living world. The protection of healthy soils and the restoration of problem soils are strongly needed in the current agricultural scenario as competition for urbanization and other human needs for land resources limits the scope for the further availability of land for agriculture. Naturally occurring degraded soils, such as acid sulphate soils, can be restored with scientific interventions and advanced management strategies. The Ganges Delta is a densely populated region, where the inhabitants’ major livelihood is agriculture. Soil acidity and salinity restrict crop performance in this coastal region, particularly the acid sulphate soils (ASSs) posing a risk to agriculture. ASSs are developed from land-use changes from mangrove forest to agricultural land in this region. There is no systematic study on these soil types covering Bangladesh and India. This paper unfolds several aspects related to the characteristics, problems, and detailed management strategies of ASSs relevant to the Gangetic Delta region where these soils continue to be used for intensive agriculture to meet the livelihood needs. Crop yields are very poor in the unmanaged ASSs due to a very low soil pH (<3.5), hampering the growth and development of crops due to nutrient deficiencies and/or toxicities, coupled with soil salinity. There is toxicity of water-soluble Fe, Al, and Mn. The phosphorus nutrition of crops in these soils is affected owing to a high soil P fixation capacity. A deficiency of micronutrients, such as Zn and Cu, was also observed; however, K availability is variable in the soil. The soil acidity is a general problem throughout the soil profile; however, extreme acidity (pH < 3.5) in particular soil horizons is a typical soil characteristic, which creates problems for its efficient management. Specific operations, such as the selective use of soil layers with good properties for crop root growth, major and minor nutrient applications, and soil amendments, including green manuring, application of biofertilizers, and soil microbes, are gradually improving the properties of these soils and bringing back the potential for good crop production. Scientific water/drainage management is needed to gain an agronomic advantage. Evidence of increased crop yields in these soils observed from green manuring, lime, basic slag, and rock phosphate application are presented.