“Acide aminé-acide ribonucléique”, intermédiaire dans la synthèse des liaisons peptidiques. VI

Beljanski, Mirko; Beljanski, M

doi:10.1016/0006-3002(63)90285-3

Cited by 4 publications

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“…Beljanski et al (1963Beljanski et al ( , 1968 reported that enzymes from Alcaligenes faecalis attach amino acids to single-strand RNA by means of ester bonds throughout the length of the strand. The amino acyl esters then spontaneously condense to form peptides.…”

Section: Discussionmentioning

confidence: 99%

Enhancement of peptide bond formation by polyribonucleotides on clay surfaces in fluctuating environments

White

Erickson

1981

J Mol Evol

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Summary. The condensation of glycine to form oligoglycine during temperature and moisture fluctuations on clay surfaces was enhanced up to fourfold by polyribonucleotides. Polydeoxyribonucleotides gave no enhancement. Yields were greatly reduced in the absence of clay. A small preference was observed among the polyribonucleotide bases with enhancements in the order of Poly G > Poly A = Poly U > Poly C at high density of polynucleotide on the clay surface and Poly G > Poly U > Poly C > Poly A at low density. This and other experiments seem to indicate a codonic bias in the interaction of polynucleotides with amino acids reacting to form peptide bonds. A mechanism is proposed which involves (1) activation of glycine on the clay surface, (2) formation of esters between glycine and the 2'-OH groups of the polyribonucleotide, and (3) formation of peptide bonds between adjacent amino acyl esters. If this mechanism is correct, it may provide the basis for a simple, direct-template translation process.

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Section: Discussionmentioning

confidence: 99%

Enhancement of peptide bond formation by polyribonucleotides on clay surfaces in fluctuating environments

White

Erickson

1981

J Mol Evol

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“…Les RNA ont 6th isoles B l'aide de phbnol et les fractions enriches en RNA B marquage rapide (mRNA) ont 6th obtenues par fractionnement des RNA totaux i i l'aide de sulfate d'ammonium d'aprbs la methode dbcrite [4]. Une fraction de RNA actif prhcipitant entre 60-65 O i 0 , et l'autre entre 80-90°/, de la saturation en sulfate d'ammonium, ont 6th caracterisees comme RNA ii marquage rapide [4]. Le l'raitement avec NaIO,.…”

Section: Matgriel Et Mgthodesunclassified

“…coli [4]. Dans la pr6paration des polypeptide synthbtases il existe trBs certainement un enzyme pour chaque acide amink catalysant en presence soit de chacun des quatre ribonucleoside-5'-triphosphates, soit de deux seulement, la fixation d'un acide amini?…”

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Identification des sites d'attachement spécifiques d'arginine VIII et de valine dans des RNA d'origines différentes

Beljanski

Fischer-Ferraro

Bourgarel

1968

European Journal of Biochemistry

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Activité néformatrice d'acides ribonucléiques extraits de tumeurs végétales

Roussaux

1975

Physiologia Plantarum

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RNAs extracted from crown‐gall tumors, induced by Agrobacterium tumefaciens (strain B6) on stems of Datura stramonium L., have been isolated by the phenol method and purified through Biogel P 60 columns. These RNAs have been transformed into complexes with l‐amino acids by incubation in a medium containing: Tris HCI buffer, pH 7.6, ATP, MgCl2, a mixture of l‐amino acids and a polypeptide synthetase purified from Alcaligenes faecalis. The inoculation of stems of Datura plants with these complexes induces the development of nodular outgrowths, whereas other complexes made from RNAs isolated from healthy Datura plants, from Agrobacterium tumefaciens, Escherichia coli and Alcaligenes faecalis do not cause any hyperplasia under our experimental conditions. The analysis of the results obtained, supported by histological studies of the outgrowths, suggests that these neoformations should be of tumoral nature.

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“Acide aminé-acide ribonucléique”, intermédiaire dans la synthèse des liaisons peptidiques. VI

Cited by 4 publications

References 0 publications

Enhancement of peptide bond formation by polyribonucleotides on clay surfaces in fluctuating environments

Enhancement of peptide bond formation by polyribonucleotides on clay surfaces in fluctuating environments

Identification des sites d'attachement spécifiques d'arginine VIII et de valine dans des RNA d'origines différentes

Activité néformatrice d'acides ribonucléiques extraits de tumeurs végétales

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