Acidic and Basic Solutions Dissolve Protein Plugs Made of Lithostathine Complicating Choledochal Cyst/Pancreaticobiliary Maljunction

Kaneko, Kenitiro; Ono, Yoshio; Tainaka, Takahisa; Sumida, Wataru; Ando, Hisami

doi:10.1007/s10620-008-0503-8

Cited by 5 publications

(2 citation statements)

References 10 publications

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“…Insoluble lithostathine forms raw fibers through self‐assembly by means of electrical coupling, which are gathered together to create protein plugs . Experimentally, electric coupling is eliminated by acid and base, and protein plugs are dissolved .…”

Section: Chapter Iv: Treatments and Diagnosismentioning

confidence: 99%

Japanese clinical practice guidelines for congenital biliary dilatation

Ishibashi

Shimada

Kamisawa

et al. 2017

J Hepatobiliary Pancreat Sci

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115

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Until now, there have been no practical clinical guidelines for congenital biliary dilatation (CBD). In this review article, the Japanese Study Group on Congenital Biliary Dilatation (JSCBD) propose to establish clinical practice guidelines for CBD. Because the evidence-based literature is relatively small, we decided to create guidelines based on the consensus of experts, using the medical literature for reference. A total of 20 clinical questions (CQs) were considered by the members of the editorial committee responsible for the guidelines. The CQs included the distinct aspects of CBD: (1) Concepts and Pathology (three CQs); (2) Diagnosis (six CQs); (3) Pancreaticobiliary Complications (three CQs); Treatments and Prognosis (eight CQs). Each statements and comments for CQs were made by the guidelines committee members. CQs were finally approved after review by members of the editorial committee and the guidelines evaluation board of CBD. These guidelines were created to provide assistance in the clinical practice of CBD management; their contents focus on clinical utility, and they include general information on CBD to make this disease more widely recognized.

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Section: Chapter Iv: Treatments and Diagnosismentioning

confidence: 99%

Japanese clinical practice guidelines for congenital biliary dilatation

Ishibashi

Shimada

Kamisawa

et al. 2017

J Hepatobiliary Pancreat Sci

Self Cite

115

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“…Many authors reported protein plugs and/or stones in the common channel in children with congenital fusiform biliary dilatation, which resulted in common biliary obstruction and caused clinical symptoms. [ 14 15 ] The abdominal pain is a main symptom of our 18 patients. Of the patients, elevated serum and urinary amylase occured in 13 patients when abdominal pain appeared.…”

Section: Discussionmentioning

confidence: 99%

Combination of laparoscopy and endoscopy for fusiform choledochal cysts

et al. 2016

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OBJECTIVE:The purpose of the study was to elucidate the efficacy of laparoscopy and endoscopy in the treatment of fusiform choledochal cysts (CDC).MATERIALS AND METHODS:Between June 2006 and June 2012, 18 patients with fusiform CDC were treated in our hospital. All the 18 patients presented abdominal pain, and 13 presented jaundice. 18 patients presented elevated serum and urinary amylase, when abdominal pain appeared. All the patients underwent laparoscopic and endoscopic surgery successfully. The clinical presentation, radiological features and surgical treatment were analyzed. The postoperative symptoms, laboratory examination and bile duct changes were evaluated during follow-up term.RESULTS:Intraoperative cholangiography showed filling defect, dilatation of the common channel and pancreatic ducts visualization in 18 patients, including 9 patients of pancreatic duct dilatation. The protein plugs and/or stones were removed completely under laparoscopy and endoscopy in 18 patients. Patients were followed-up for 3 months to 6 years. The biochemical and ultrasound examination showed no increase in pancreatic amylase and recurrence of the stones in the common channel and pancreatic duct.CONCLUSIONS:The children with congenital fusiform biliary dilatation presented abdominal pain. Patients presented elevated serum and urinary amylase, when abdominal pain occurred. Filling defect and dilatation of the common channel showed by cholangiography. Laparoscopy and endoscopy clearance of the protein plugs and/or stones in the common channel in congenital fusiform biliary dilatation is effective, and the long-term result is good.

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Cholangiocarcinomas Arising in Cystic Lesions of the Hepatobiliary Tract and in Pancreaticobiliary Maljunction

Zimmermann¹

2016

Tumors and Tumor-Like Lesions of the Hepatobiliary Tract

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Acidic and Basic Solutions Dissolve Protein Plugs Made of Lithostathine Complicating Choledochal Cyst/Pancreaticobiliary Maljunction

Abstract: Protein plugs in choledochal cysts are dissolved in acidic and basic solutions, which may eliminate longitudinal electrostatic interactions of the lithostathine protofibrils.

Cited by 5 publications

References 10 publications

Japanese clinical practice guidelines for congenital biliary dilatation

Japanese clinical practice guidelines for congenital biliary dilatation

Combination of laparoscopy and endoscopy for fusiform choledochal cysts

Cholangiocarcinomas Arising in Cystic Lesions of the Hepatobiliary Tract and in Pancreaticobiliary Maljunction

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