Acidic Exopolysaccharide Produced from Marine <i>Bacillus amyloliquefaciens</i> 3MS 2017 for the Protection and Treatment of Breast Cancer

Ibrahim, Abeer Y.; Youness, Eman R.; Mahmoud, Manal G.; Asker, Mohsen S.; El-Newary, Samah A.

doi:10.1177/1178223420902075

Cited by 14 publications

(12 citation statements)

References 50 publications

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“…While TGF-β1 positive cells significantly reduced in treated groups which specify that Myrrh suppresses DEN induced hepatocarcinogenesis by its inhibitory effects on HSC activation through suppressing TGF-β1 expression (El-Shahat et al, 2012). CEA tumor marker is a glycoprotein that acts as a cell adhesion factor and is increased in the circulation due to a weakness of cell connection through tumor growth (Yoshikawa et al, 2017, Ibrahim et al, 2020. Subsequently, CEA typically occurs at very low levels in the blood.…”

Section: Discussionmentioning

confidence: 99%

The Therapeutic Effect of Myrrh (Commiphora molmol) and Doxorubicin on Diethylnitrosamine Induced Hepatocarcinogenesis in Male Albino Rats

Anwar

Moghazy

Osman

et al. 2021

Asian Pac J Cancer Prev

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Background: This study was conducted to assess the therapeutic effect of Myrrh on Diethylnitrosamine (DEN)induced hepatocarcinogenesis (HCC) in male albino rats. Methods: Fifty male albino rats were divided into five groups (10 rats each). Group 1 (control group) received distilled water. Group 2 (positive control) was injected intraperitoneally with DEN (55 mg/kg b.w) twice a week for two weeks, while group 3 (DOX) received doxorubicin i.p (10 mg/ kg b.w) after concomitant with DEN twice a week for four weeks. Groups 4 and 5 received a low dose of Myrrh (250 mg/kg b.w) and a high dose of Myrrh (500 mg/kg b.w) respectively daily for four weeks after the induction with DEN. The sera were used to estimate the liver enzymes (ALT, AST, and ALP), Alpha-fetoprotein (AFP), Total antioxidant capacity (TAC), and Tumor necrosis factor-ἁ (TNF-ἁ). Also, the liver tissues were collected to determine the oxidative stress markers in addition to the histopathological and immunohistochemical investigations. Results: The results showed that the induction of DEN causes a significant increase in the level of liver enzymes (ALT, AST, and ALP), AFP and TNF-ἁ as well as produce oxidative stress indicated by increasing of malondialdehyde (MDA) with the reduction in TAC and glutathione (GSH). Meanwhile, there are noticeable histopathological lesions with loss of hepatic architecture. This was accompanied by a significant increase of immunohistochemical markers; Caspase-3, vascular endothelial growth factor (VEGF), transforming growth factor β1(TGF-β1), and carcinoembryonic antigen (CEA) percentage area. The treatment of DEN rats with DOX reduced the alterations in most parameters. A marked amelioration of all parameters in a dose-dependent manner of Myrrh to the values almost near to those of the control group. Conclusion: Our data revealed that Water extract of Myrrh (C. molmol) has a potential therapeutic effect in attenuation of HCC induced DEN.

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Section: Discussionmentioning

confidence: 99%

The Therapeutic Effect of Myrrh (Commiphora molmol) and Doxorubicin on Diethylnitrosamine Induced Hepatocarcinogenesis in Male Albino Rats

Anwar

Moghazy

Osman

et al. 2021

Asian Pac J Cancer Prev

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“…These effects were partially confirmed by Abou Zaid et al [ 48 ], who found variation in the architecture of the DMBA mammary gland tissues, ranging from hyperplasia to anaplasia in the lining epithelium of the acini. Also, Ibrahim et al [ 49 ] research discovered the capability of DMBA to increase the proliferation of rat breasts. Contrariwise, the study clarified that Chia oil encapsulation improved the tissue architecture of breast tumor animals.…”

Section: Discussionmentioning

confidence: 99%

The suppressive role of nanoencapsulated chia oil against DMBA-induced breast cancer through oxidative stress repression and tumor genes expression modulation in rats

et al. 2022

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Background Chia oil is high in omega-3 fatty acids, which have been linked to a lower risk of many diseases, including cancer. Oil encapsulation is a method that holds promise for maintaining oil content while enhancing solubility and stability. The purpose of this study is to prepare nanoencapsulated Chia oil and investigate its suppressive effects on rat chemically induced breast cancer. Methods The oil was extracted from commercial Chia seeds and their fatty acids were analyzed using Gas Chromatography–mass spectrometry (GC/MS). Sodium alginate was used as a loading agent to create the Chia oil nanocapsules. The DPPH assay was used to assess the oil nanocapsules' capacity to scavenge free radicals. Breast cancer induction was done by single dose subcutaneously administration of 80 mg/kg dimethylbenz (a) anthracene (DMBA). Models of breast cancer were given Chia oil nanocapsules orally for one month at doses of 100 and 200 mg/kg. Through measuring intracellular reactive oxygen species (ROS) and protein carbonyl, assessing the gene expression of tumor suppressor genes (BRCA 1 & 2, TP53), and conducting histopathological analysis, the suppressive effect of Chia oil nanocapsules was examined. Results The increase in ROS and PC levels brought on by DMBA was significantly decreased by the administration of Chia oil nanocapsules. In tumor tissue from rats given Chia oil nanocapsules, the mRNA expression levels of BRCA1, BRCA2, and TP53 were controlled Histopathological analysis clarified that the tissue architecture of breast tumors was improved by nanocapsules management. Conclusions These findings demonstrate the ability of Chia oil nanocapsules to inhibit cancer cells in the rat breast.

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“…[48], who found variation in the architecture of the DMBA mammary gland tissues, ranging from hyperplasia to anaplasia in the lining epithelium of the acini. Also, Ibrahim et al [49] research discovered the capability of DMBA to increase the proliferation of rat breasts. Contrariwise, the study clari ed that Chia oil encapsulation improved the tissue architecture of breast tumor animals.…”

Section: Discussionmentioning

confidence: 99%

The Suppressive role of Nanoencapsulated Chia oil against DMBA-induced breast cancer through oxidative stress repression and tumor genes expression modulation in rats

Makawy

Mabrouk

Mohammed³

et al. 2022

Preprint

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Chia oil is high in omega-3 fatty acids, which have been linked to a lower risk of many diseases, including cancer. Oil encapsulation is a promising method for preserving oil content and improving solubility and stability. This study aims to prepare nano-encapsulated Chia oil and explore its suppressive role against chemically induced breast cancer in rats. The oil was extracted from commercial Chia seeds and their fatty acids were analyzed using Gas Chromatography-Mass Spectrometry (GC/MS). The Chia oil nanocapsules were prepared by using sodium alginate as a loading agent. The ability of oil nanocapsules to scavenge free radicals was determined using the DPPH radical scavenging assay. Breast cancer was induced via a single-dose subcutaneous injection of 80 mg/kg dimethylbenz(a)anthracene (DMBA). Breast cancer models were orally treated with Chia oil nanocapsules at doses of 100 & 200mg/kg for one month. The suppressive effect of Chia oil nanocapsules was investigated through estimation of intracellular reactive oxygen species (ROS) and protein carbonyl, gene expression of tumor suppressor genes (BRCA 1 & 2, TP53) evaluation, and histopathological analysis. The administration of Chia oil nanocapsules significantly reduced the increase in ROS and PC levels induced in DMBA groups. On the molecular level, the mRNA expression levels of BRCA1, BRCA2, and TP53 were modulated in tumor tissue of rats given Chia oil nanocapsules. According to the histopathological analysis, nanocapsules improved the tissue architecture of breast tumors. These findings demonstrate the ability of Chia oil nanocapsules to inhibit cancer cells in the rat breast.

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Acidic Exopolysaccharide Produced from Marine Bacillus amyloliquefaciens 3MS 2017 for the Protection and Treatment of Breast Cancer

Cited by 14 publications

References 50 publications

The Therapeutic Effect of Myrrh (Commiphora molmol) and Doxorubicin on Diethylnitrosamine Induced Hepatocarcinogenesis in Male Albino Rats

The Therapeutic Effect of Myrrh (Commiphora molmol) and Doxorubicin on Diethylnitrosamine Induced Hepatocarcinogenesis in Male Albino Rats

The suppressive role of nanoencapsulated chia oil against DMBA-induced breast cancer through oxidative stress repression and tumor genes expression modulation in rats

The Suppressive role of Nanoencapsulated Chia oil against DMBA-induced breast cancer through oxidative stress repression and tumor genes expression modulation in rats

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