Acidic Handle Assemble Heterogeneous Carbocatalyst for Facile Aliphatic Nucleophilic Fluorination

Abstract

Acidic handle (-SO 3 H) assemble carbonaceous catalyst synthesized from glucose acts as a modulator for the nucleophilic fluorination reaction. The heterogeneous catalyst works with various alkyl sulfonate, halide and metal fluoride (MF), to offer a high yield of fluorinated products up to 93%. This carbonaceous catalyst is recyclable for more than five times, with no major loss of activity.

Electron-Deficient Fluoroarene-Mediated Synthesis of Trifluoromethyl Ketones from Carboxylic Acids

“…However, this protocal requires stoichiometric amounts of metal (CuI) and oxidant (PPh 3 , NBS) and also forms a dihydroxy byproduct. In continuation of our interest to develop green methodologies for fluorination, herein we report the synthesis of trifluoromethyl ketones from carboxylic acids mediated by highly electron-deficient fluoroarenes (FAs) (Scheme B).…”