Acidic Rearrangement of (Benzyloxy)chalcones: A Short Synthesis of Chamanetin

Abstract

Treatment of (benzyloxy)chalcones with trifluoroacetic acid in refluxing chloroform gave several new benzyl(hydroxy)flavanones in high yields and good regioselectivities. By using this procedure, we prepared the natural compound chamanetin in good yield from readily available reagents.