Acidic Urine Is Associated With Poor Prognosis of Upper Tract Urothelial Carcinoma

Han, Jang Hee; Jeong, Sangman; Yuk, Hyeong Dong; Jeong, Chang Wook; Kwak, Cheol; Ku, Ja Hyeon

doi:10.3389/fonc.2021.817781

Cited by 2 publications

(2 citation statements)

References 30 publications

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“…Han et al . 25 has demonstrated that multifocal tumors, acidic urine pH, and advanced T-stage independently shorten recurrence-free survival. A study conducted by Wright et al .…”

Section: Discussionmentioning

confidence: 99%

Intravesical mitomycin C efficacy in acidic and alkaline urinary pH: impact on recurrence-free survival rate after TURBT

Naeem,

Usman,

Ali

et al. 2023

Annals of Medicine &Amp; Surgery

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Background: Urinary bladder tumor recurrence following TURBT is a common issue. This study aims to determine how urine alkalinization affects bladder tumor recurrence after surgery. Methodology: Sixty patients receiving mitomycin C therapy after TURBT were divided into two groups based on mean pH values. Twenty-six patients were in Group A, whose urine pH was below 5.5. However, there were 34 patients in Group B, and their urine pH was higher than 5.5. Both groups of patients were given intravesical mitomycin C once weekly for six weeks following TURBT. A cystoscopy was performed as a follow-up at 3, 6, and 12 months. Urine pH and the RFS rate were compared using Kaplan Meier survival analysis and the Cox proportional hazard model. Results: The mean time to tumor recurrence in Group A (intravesical mitomycin C in acidic urine) and Group B (intravesical mitomycin C in alkaline urine) was 12.48 months vs. 16.84 months, respectively. Alkaline urine pH was identified as an independent predictor in preventing the recurrence of superficial bladder tumors by univariate COX regression analysis. Age, gender, and mean tumor size did not affect the likelihood of tumor recurrence. However, smoking had an association with increased tumor recurrence. Conclusion: Tumor recurrence post-TURBT is delayed in patients with alkaline urine pH. Smoking is an independent risk factor for bladder tumors.

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“…Han et al . 25 has demonstrated that multifocal tumors, acidic urine pH, and advanced T-stage independently shorten recurrence-free survival. A study conducted by Wright et al .…”

Section: Discussionmentioning

confidence: 99%

Intravesical mitomycin C efficacy in acidic and alkaline urinary pH: impact on recurrence-free survival rate after TURBT

Naeem,

Usman,

Ali

et al. 2023

Annals of Medicine &Amp; Surgery

View full text Add to dashboard Cite

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“…For example, acidic urine has been found to be common in patients with sarcopenia ( 12 ), coronary artery disease ( 13 ), DM ( 14 ), and metabolic syndrome ( 15 ). In investigations related to nephro-urology, acidic urine was reported to increase the risk of chronic renal failure and urolithiasis ( 16 , 17 ), and may also be associated with poor prognosis in urothelial carcinoma patients ( 18 ). On the other hand, alkaline urine is commonly found in urinary tract infection cases and often promotes formation of infected urolithiasis.…”

Section: Discussionmentioning

confidence: 99%

Urine pH and imaging findings of prostate useful predictors of prolonged duration of hematospermia

Mitsui¹,

Yamabe²,

Hori³

et al. 2023

Transl Androl Urol

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Background Few investigations regarding hematospermia duration have been reported thus far. The aim of this study was to identify clinical factors associated with the duration of hematospermia. Methods Clinical data of 198 patients with hematospermia treated at Toho University Omori Medical Center from 2007 to 2022 were retrospectively evaluated. To identify independent predictors of hematospermia duration, uni- and multivariate Cox analyses were performed. Receiver operating characteristic analysis, Kaplan-Meier survival curves, and propensity score matching were applied for statistical evaluations. Results Multivariate analysis of all 198 patients showed urine pH (UpH) level and any abnormal imaging finding of the prostate to be independent predictors of hematospermia duration. Based on the receiver-operating curve of UpH level for hematospermia improvement, the patients were divided into two groups using a threshold of 6.0 (Low-UpH 5.0–6.0, n=128; High-UpH 7.0–9.0, n=70). Kaplan-Meier curves indicated that patients in the High-UpH group or with any abnormal imaging finding had a higher rate of hematospermia persistence (both P<0.05). Even after matching between the groups classified by UpH (n=60 each), multivariate analysis showed that UpH level (hazard ratio 0.75, 95% CI: 0.61–0.92; P=0.006) and any abnormal imaging finding (hazard ratio 1.55, 95% CI: 1.04–2.31; P=0.033) were independent predictors of hematospermia duration. In Kaplan-Meier analysis findings of matched cohorts, High-UpH and presence of any abnormal imaging findings remained significantly correlated with higher rate of hematospermia persistence, while further stratification using a combination of these two factors identified a stepwise reduction in that rate (P=0.019). In addition, the proportion of patients with these two factors present simultaneously was significantly higher in the group with hematospermia for two months or more, and especially with a duration of greater than six months, than in the group with a duration of less than two months. Conclusions Although further research is needed, both UpH level and imaging findings of the prostate are considered useful biomarkers for predicting prolonged hematospermia.

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Acidic Urine Is Associated With Poor Prognosis of Upper Tract Urothelial Carcinoma

Cited by 2 publications

References 30 publications

Intravesical mitomycin C efficacy in acidic and alkaline urinary pH: impact on recurrence-free survival rate after TURBT

Intravesical mitomycin C efficacy in acidic and alkaline urinary pH: impact on recurrence-free survival rate after TURBT

Urine pH and imaging findings of prostate useful predictors of prolonged duration of hematospermia

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