Acidified Milk Formula Supplemented With Bifidobacterium lactis: Impact on Infant Diarrhea in Residential Care Settings

Chouraqui, J.-P.; Egroo, Louis-Dominique Van; Fichot, Marie-Claire

doi:10.1097/00005176-200403000-00011

Cited by 178 publications

(121 citation statements)

References 27 publications

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“…The latter combination exerted prophylactic activity against infectious rotavirus diarrhea in children (Saavedra et al, 1994;Chouraqui et al, 2004). Furthermore, long-term consumption seems to be well tolerated in infants and a significantly lower frequency of colic or abdominal irritability was reported in two different doses of probiotic intake compared to the placebo group (Saavedra et al, 2004).…”

Section: Introductionmentioning

confidence: 97%

“…BB-12 has been used in clinical trials either alone (Fukushima et al, 1997;Fukushima et al, 1998;Isolauri et al, 2000;Kirjavainen et al, 2002) or together with other bacteria such as Lactobacillus acidophilus LA-5 (Alm et al, 1993;Laake et al, 1999) or Streptococcus thermophilus (Langhendries et al, 1995;Chouraqui et al, 2004;Saavedra et al, 2004). The latter combination exerted prophylactic activity against infectious rotavirus diarrhea in children (Saavedra et al, 1994;Chouraqui et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

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Dose–response study of probiotic bacteria Bifidobacterium animalis subsp lactis BB-12 and Lactobacillus paracasei subsp paracasei CRL-341 in healthy young adults

Larsen

Nielsen²,

Kæstel³

et al. 2006

Eur J Clin Nutr

109

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Objective: This study was performed to investigate the dose-response effects of supplementation with Bifidobacterium animalis subsp lactis (BB-12) and Lactobacillus paracasei subsp paracasei (CRL-431) on blood lipids, recovery from feces and bowel habits. Changes of the fecal microflora was analyzed in the 10 10 CFU/day probiotic and placebo group. Design: The study was designed as a randomized, placebo-controlled, double-blinded, parallel dose-response study. Subjects: Healthy young adults (18-40 years) were recruited by advertising in local newspapers. Of the 75 persons enrolled, 71 (46 women, 25 men, mean age 25.6 years (range 18-40 years)) completed the study. Intervention: The volunteers were randomly assigned into five groups receiving either placebo or a mixture of the two probiotics in the concentration of 10 8 , 10 9 , 10 10 or 10 11 CFU/day in 2 weeks run-in period, 3 weeks intervention and 2 weeks wash-out. Diary reporting bowel habits and well being (abdominal bloating, flatulence and headache) was kept for all 7 weeks and blood lipids, fecal recovery of BB-12 and CRL-431, as well as fecal microflora was tested before, immediately and 2 weeks after intervention. Results: The fecal recovery of BB-12 increased significantly (Po0.001) with increasing dose. In the group receiving 10 11 CFU/ day BB-12 was recovered from 13 out of 15 volunteers. CRL-431 was not recovered in any of the fecal samples. Supplementation with probiotics did not change the fecal bacterial composition. A significant linear increase in fecal consistency (looser stool) with increasing probiotic dose (P ¼ 0.018) was observed. No overall dose-response effect was found on the blood lipids. High doses of probiotics were well tolerated. Conclusion: A dose-related recovery of BB-12 from feces was observed. Sponsorship: The study was sponsored by Chr. Hansen A/S, Hoersholm, Denmark. Keywords: dose-response study; probiotics; cholesterol; recovery from feces; constipation European Journal of Clinical Nutrition IntroductionIt is generally accepted that the composition of the intestinal microflora influences the health and well being of humans. With the many publications showing beneficial effects of probiotic bacteria, there has been an increasing interest in the mechanism behind. Most clinical studies have tested only one dose of probiotics, ranging from 4 Â 10 8 CFU/day for determination of gastrointestinal colonization and immune modulation (Valeur et al., 2004) Contributors: DCE, CNL and KFM wrote the protocol. DCE performed the study. CNL did the microbiological analysis of fecal samples and study product. EB performed the fluorescent whole cell hybridization of BB-12 like colonies. MB performed the PFGE of CRL-431 like colonies. PK performed the statistical analysis. CNL and SN wrote the first draft of the paper and all contributors participated in the revision and final approval of the paper.

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Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Dose–response study of probiotic bacteria Bifidobacterium animalis subsp lactis BB-12 and Lactobacillus paracasei subsp paracasei CRL-341 in healthy young adults

Larsen

Nielsen²,

Kæstel³

et al. 2006

Eur J Clin Nutr

109

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“…S. thermophilus and L. helveticus. 6 Velaphi et al further reported that infants receiving acidified formula had similar growth patterns to those in infants fed a standard whey formula, irrespective of the method of acidification. However, the addition of B. lactis to acidified formula resulted in greater weight gain, compared to that with standard formula.…”

Section: Acidified Formula With Added Probiotic Agentsmentioning

confidence: 95%

“…4 Despite the numerous benefits of breastfeeding, it is not always an option or possible, as many women are unable to, or choose not to, breastfeed. 5,6 A wide range of infant formula is commercially available, including acidified infant formula. Research indicates that intestinal infection is reduced in infants who receive biologically acidified infant formula.…”

Section: Introductionmentioning

confidence: 99%

Acidified infant formula explained

Labuschagne

Niekerk

Lombard

2013

South African Family Practice

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The development of effective methods to prevent acute gastroenteritis is an important goal for infant health. Exclusive breastfeeding and postponement of complementary foods until the age of six months is recommended for healthy infants. However, at times, infant formula is required. Various types are commercially available. Acidified cow's milk formula has been found to prevent the growth of pathogenic bacteria and concurring diarrhoeal disease.Peer reviewed.

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“…lactis (B. lactis), marketed as BB-12, is a commercially available probiotic strain that is considered one of the most well characterized and studied probiotics, particularly in reducing illness in young children. (Black et al, 1989;Alm et al, 1993;Link-Amster et al, 1994;Saavedra et al, 1994;Schiffrin et al, 1995;Obradovic et al, 1996;Kankaanpaa et al, 1998;Phuapradit et al, 1999;Matsumoto et al, 2001;Chouraqui et al, 2004;Amrouche et al, 2006a, b;Taipale et al, 2011). Long-term consumption of BB-12-fortified formula at levels as high as 240 billion colony-forming unit (CFU) per day has been shown to be safe and well tolerated (Abi-Hanna et al, 1998;Saavedra et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Study to investigate the potential of probiotics in children attending school

et al. 2011

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Background/Objectives: To determine if consumption of yogurt containing a high dose of probiotic (1 Â 10 10 colony-forming unit per 100 ml), Bifidobacterium animalis subsp. lactis (B. lactis), decreases absences in children 2-4 years attending daycare/ school centers. Subjects/Methods: We conducted a double-blinded, randomized, placebo-controlled, allocation concealment clinical trial in the Washington, DC area. Our active intervention was a strawberry yogurt-based drink supplemented with B. lactis BB-12. The placebo was indistinguishable from the active drink, differing only in absence of the probiotic BB-12.Results: A total of 172 children between the ages of 2 and 4 from the Washington, DC area were enrolled. The primary outcome, missed days of school because of illness per 100 days, was similar in both the active (2.54 days absent/100 school days) and control groups (2.42 days absent/100 school days) (P ¼ 0.873). Conclusions: The probiotic-containing yogurt-based beverage studied did not decrease absences because of illnesses in daycare/school for healthy children ages 2-4 years.

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Acidified Milk Formula Supplemented With Bifidobacterium lactis: Impact on Infant Diarrhea in Residential Care Settings

Abstract: These results provide some evidence that viable Bifidobacterium lactis strain Bb 12, added to an acidified infant formula, has some protective effect against acute diarrhea in healthy children.

Cited by 178 publications

References 27 publications

Dose–response study of probiotic bacteria Bifidobacterium animalis subsp lactis BB-12 and Lactobacillus paracasei subsp paracasei CRL-341 in healthy young adults

Dose–response study of probiotic bacteria Bifidobacterium animalis subsp lactis BB-12 and Lactobacillus paracasei subsp paracasei CRL-341 in healthy young adults

Acidified infant formula explained

Study to investigate the potential of probiotics in children attending school

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