Ácidos graxos poli-insaturados n-3 e n-6: metabolismo em mamíferos e resposta imune

Perini, João Angelo Lima; Stevanato, Flávia Braidotti; Sargi, Sheisa Cyléia; Visentainer, Jeane Eliete Laguila; Dalalio, Márcia Machado de Oliveira; Matshushita, Makoto; Souza, Nilson Evelázio de

doi:10.1590/s1415-52732010000600013

Cited by 71 publications

(70 citation statements)

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“…The compounds aforementioned are usually found in tissues and biological fluids, and are used in vital organism processes maintenance (Perini et al, 2010). They promote cell proper functioning and perform important functions for the organism, such as reducing the risks of cardiovascular and immunological disorders.…”

Section: Introductionmentioning

confidence: 99%

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Fungi as an alternative to produce essential fatty acids

Francisco¹,

Saldanha²,

Fraga³

2017

Científica

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Fungi have the ability to produce essential fatty acids of the omega-3 family, what is of great scientific interest, since these microorganisms are capable of developing under varied conditions, making their production a viable alternative. Fatty acids are of great importance in human food due to their beneficial effects to the organism, such as reduction in the development of cardiovascular problems and other chronic-degenerative diseases. Currently, the main food source of omega-3 fatty acids is saltwater fish, but there are concerns about potential health risks, including environmental contaminants, such as some metals, as well as ecological issues related to the extinction of some species. Therefore, interest in the biotechnology area has been increasing with the aim of extracting bioactive compounds from certain fungi species, besides using these species to produce biomass, food, and energy, among others.Additional keywords: biomass; biotechnology; industrial application; polyunsaturated fatty acids. ResumoA capacidade de produção de ácidos graxos essenciais da família ômega 3 por fungos é de grande interesse científico, uma vez que estes microrganismos são capazes de se desenvolver em condições variadas, apresentando-se como alternativa viável para a produção dos mesmos. Os referidos ácidos graxos são de grande importância na alimentação humana, devido seus efeitos benéficos ao organismo, como, por exemplo, a redução no desenvolvimento de problemas cardiovasculares e de outras doenças crônico-degenerativas. Atualmente, a principal fonte alimentar de ácidos graxos ômega 3 é a ingestão de pescados marinhos, mas existem algumas preocupações sobre os riscos potenciais para a saúde, incluindo contaminantes ambientais, tais como alguns metais, além de questões ecológicas relacionadas com a extinção de algumas espécies. Portanto, o interesse pela área da biotecnologia vem crescendo com o objetivo de extrair compostos bioativos de certas espécies de fungos, além de sua utilização para produção de biomassas, alimentos, energia, dentre outros de importância econômica.Palavras-chave adicionais: ácidos graxos poli-insaturados; aplicação industrial; biomassa; biotecnologia.

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Section: Introductionmentioning

confidence: 99%

“…In addition, omega-3 and omega-6 also promote blood pressure regulation, neuroprotection, mood stabilization, and inflammatory states reduction. They also help transmitting nerve impulses, among other important organism functions (Nuria et al, 2010;Perini et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Fungi as an alternative to produce essential fatty acids

Francisco¹,

Saldanha²,

Fraga³

2017

Científica

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“…PUFAs are biosynthesis precursors of several important metabolites, especially eicosanoids (prostaglandins, leukotrienes, thromboxanes, lipoxins, and others), synthesized from arachidonic acid [31]. Omega-3 PUFAs reduce arachidonic acid content in cell membranes, resulting in the synthesis of eicosanoids that have greater anti-inflammatory properties than the eicosanoids derived from omega-6 PUFAs [32].…”

Section: Discussionmentioning

confidence: 99%

Omega-3 supplementation on inflammatory markers in patients with chronic Chagas cardiomyopathy: a randomized clinical study

Silva

Mediano

Silva

et al. 2017

Nutr J

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BackgroundSeveral studies have been focusing on the effect of omega-3 polyunsaturated fatty acids on modulation of inflammatory markers in several cardiopathies. Although immunoregulatory dysfunction has been associated to the chronic cardiac involvement in Chagas disease, there is no study examining the effects of omega-3 supplementation in these patients. We investigated the effects of omega-3 PUFAs on markers of inflammation and lipid profile in chronic Chagas cardiomyopathy patients.MethodsThe present study was a single-center double-blind clinical trial including patients with chronic Chagas cardiomyopathy. Patients were randomly assigned to receive omega-3 PUFAs capsules (1.8g EPA and 1.2g DHA) or placebo (corn oil) during an 8-week period. Cytokines, fasting glucose, lipid, and anthropometric profiles were evaluated.ResultsForty-two patients (23 women and 19 men) were included in the study and there were only two losses to follow-up during the 8-week period. Most of sociodemographic and clinical characteristics were similar between the groups at baseline, except for the cytokines IL-1β, IL-6, IL-8, IL-10, IL-17α, and IFNγ. The omega-3 PUFAs group demonstrated greater improvements in serum triglycerides (−21.1 vs. −4.1; p = 0.05) and IL-10 levels (−10.6 vs. −35.7; p = 0.01) in comparison to controls after 8 weeks of intervention. No further differences were observed between groups.ConclusionOmega-3 PUFAs supplementation may favorably affect lipid and inflammatory profile in chronic Chagas cardiomyopathy patients, demonstrated by a decrease in triglycerides and improvements on IL-10 concentration. Further studies examining the clinical effects of omega-3 fatty acids supplementation in chronic Chagas cardiomyopathy are necessary.Trial registration NCT01863576.

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“…20 Em relação ao ácido araquidônico (AA), não houve variação significativa comparando os tratamentos. O ácido eicosapentaenoico (EPA) teve seu maior índice nos tratamentos com ração controle, diminuindo consideravelmente apenas no tratamento de linhaça com 50 dias, possivelmente devido a continuação do processo metabólico (dessaturando e alongando) 21 pois observa-se no mesmo tratamento um aumento de DHA e DPA em relação aos outros tratamentos. O ácido docosapentaenoico (DPA) diminuiu com os tratamentos, sendo maior no tempo zero e menor no tratamento com linhaça durante 50 dias, enquanto o ácido docosahexaenoico reduziu em todos os tratamentos, quando comparados ao tempo zero.…”

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Incorporation of Alpha-linolenic Acid (18:3n-3) in Surubim-do-Iguaçu (Steindachneridion melanodermatum)

Zanqui¹,

Barilli²,

Ribeiro³

et al. 2015

Revista Virtual De Química

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One hundred and eighty freshwater fish, Surubim-do-Iguaçu, were distributed into three cages and fed for 25 and 50 days with control diet based on soybean oil and diet supplemented with linseed oil, rich in fatty acid 18:3n-3. The objective this work was to evaluate the incorporation of 18: 3n-3 acid during the experiment. Total lipids were extracted and fatty acids were separated in the gas chromatograph coupled to a flame ionization detector and quantified. The fish that were fed during 50 days diet supplemented with flaxseed oil, incorporated alpha-linolenic acid on your filet, increasing the amount of this fatty acid of 9.76 mg g -1 to time zero to 20.64 mg g LT -1. The best reason n-6/n-3 was found in fillets with 50 days containing flaxseed, 4.45. Thus, it is concluded that the addition of linseed oil rations brings development and improved fatty acid profile in "Surubim do Iguaçu" fillets.Keywords: Linseed oil; omega 3 fatty acid; incorporation. ResumoCento e oitenta peixes de água doce, Surubim-do-Iguaçu, foram distribuídos em três tanquesrede e alimentados durante 25 e 50 dias com ração controle, à base de óleo de soja, e ração suplementada com óleo de linhaça, rico em ácido graxo 18:3n-3. O objetivo deste trabalho foi avaliar a incorporação de ácido 18:3n-3 no decorrer do experimento. Os lipídios totais foram extraídos e seus ácidos graxos separados em cromatógrafo à gás acoplado a detector de ionização em chama e quantificados. Os peixes alimentados com ração suplementada com óleo de linhaça incorporaram ácido alfa-linolênico em seu filé, aumentando a quantidade desse ácido graxo após 50 dias de alimentação, de 9,76 mg.g -1 no tempo zero para 20,64 mg.g -1de LT no final no experimento. A melhor razão n-6/n-3 encontrada foi nos filés com 50 dias e alimentação com linhaça, 4,45. Assim, conclui-se que a adição de óleo de linhaça as rações traz incorporação e melhoria no perfil de ácidos graxos em filés de Surubim do Iguaçu.Palavras-chave: Óleo de linhaça; ácidos graxos ômega 3; incorporação.

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Ácidos graxos poli-insaturados n-3 e n-6: metabolismo em mamíferos e resposta imune

Cited by 71 publications

References 46 publications

Fungi as an alternative to produce essential fatty acids

Fungi as an alternative to produce essential fatty acids

Omega-3 supplementation on inflammatory markers in patients with chronic Chagas cardiomyopathy: a randomized clinical study

Incorporation of Alpha-linolenic Acid (18:3n-3) in Surubim-do-Iguaçu (Steindachneridion melanodermatum)

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