Acids ‘generally recognized as safe’ affect morphology and biocompatibility of electrospun chitosan/polyethylene oxide nanofibers

Stie, Mai Bay; Jones, Megan; Sørensen, Henning Osholm; Jacobsen, Jette Bredahl; Chronakis, Ioannis S.; Nielsen, Hanne Mørck

doi:10.1016/j.carbpol.2019.03.061

Cited by 36 publications

(16 citation statements)

References 20 publications

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“…The emergence and enhancement of electronic conductivity with acetic acid treatment is consistent with previously reported fabrication methods for conductive PEDOT:PSS hydrogels that also leverage interactions between PEDOT:PSS and ionic species known to enhance conductivity in PEDOT:PSS thin films by promoting phase separation of PEDOT from PSS, including certain ionic liquids [ 17 ] and acids [ 28 ] (Figure S2, Supporting Information). We chose acetic acid because it is biologically benign compared to these other reported ionic species, [ 33 ] in case any residual acid remains after neutralization with PBS.…”

Section: Resultsmentioning

confidence: 99%

Conducting Polymer‐Based Granular Hydrogels for Injectable 3D Cell Scaffolds

Feig

Santhanam

McConnell

et al. 2021

Adv Materials Technologies

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Injectable 3D cell scaffolds possessing both electrical conductivity and native tissue‐level softness would provide a platform to leverage electric fields to manipulate stem cell behavior. Granular hydrogels, which combine jamming‐induced elasticity with repeatable injectability, are versatile materials to easily encapsulate cells to form injectable 3D niches. In this work, it is demonstrated that electrically conductive granular hydrogels can be fabricated via a simple method involving fragmentation of a bulk hydrogel made from the conducting polymer PEDOT:PSS. These granular conductors exhibit excellent shear‐thinning and self‐healing behavior, as well as record‐high electrical conductivity for an injectable 3D scaffold material (≈10 S m−1). Their granular microstructure also enables them to easily encapsulate induced pluripotent stem cell (iPSC)‐derived neural progenitor cells, which are viable for at least 5 d within the injectable gel matrices. Finally, gel biocompatibility is demonstrated with minimal observed inflammatory response when injected into a rodent brain.

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Section: Resultsmentioning

confidence: 99%

Conducting Polymer‐Based Granular Hydrogels for Injectable 3D Cell Scaffolds

Feig

Santhanam

McConnell

et al. 2021

Adv Materials Technologies

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“…Another substance taken into consideration for a better release and permeation across buccal mucosa ex vivo was insulin, embedded in a structure of chitosan/PEO NFs in HFP (1,1,1,3,3,3-hexafluoro-2-propanol) [125]. For the in vitro determination of insulin release rates, using an ELISA experiment proved that elevated chitosan: PEO ratio at electrospinning process leads to faster insulin release and smaller fibers.…”

Section: Cs-nfs As Transmucosal Nanocarriersmentioning

confidence: 99%

Recent Biomedical Approaches for Chitosan Based Materials as Drug Delivery Nanocarriers

et al. 2021

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In recent decades, drug delivery systems (DDSs) based on nanotechnology have been attracting substantial interest in the pharmaceutical field, especially those developed based on natural polymers such as chitosan, cellulose, starch, collagen, gelatin, alginate and elastin. Nanomaterials based on chitosan (CS) or chitosan derivatives are broadly investigated as promising nanocarriers due to their biodegradability, good biocompatibility, non-toxicity, low immunogenicity, great versatility and beneficial biological effects. CS, either alone or as composites, are suitable substrates in the fabrication of different types of products like hydrogels, membranes, beads, porous foams, nanoparticles, in-situ gel, microparticles, sponges and nanofibers/scaffolds. Currently, the CS based nanocarriers are intensely studied as controlled and targeted drug release systems for different drugs (anti-inflammatory, antibiotic, anticancer etc.) as well as for proteins/peptides, growth factors, vaccines, small DNA (DNAs) and short interfering RNA (siRNA). This review targets the latest biomedical approaches for CS based nanocarriers such as nanoparticles (NPs) nanofibers (NFs), nanogels (NGs) and chitosan coated liposomes (LPs) and their potential applications for medical and pharmaceutical fields. The advantages and challenges of reviewed CS based nanocarriers for different routes of administration (oral, transmucosal, pulmonary and transdermal) with reference to classical formulations are also emphasized.

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“…CS and PEO represent a blended mixture from two structurally different polymers that interact together without any covalent bond formation. It was already demonstrated that after CS/PEO electrospinning, PEO can be removed subsequently from the nanofibers by simply incubating the CS/PEO nanofibers in water for a few days [37,38]. Many nanofibers of PEO and CS blends have been fabricated by electrospinning based on the interaction between PEO moieties and CS chains [39], as shown in Fig.…”

Section: Electrical Conductivitymentioning

confidence: 99%

Chitosan/PEO nanofibers electrospun on metallized track-etched membranes: fabrication and characterization

Pereao

Uche

Bublikov

et al. 2021

Materials Today Chemistry

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The development of next-generation adsorption, separation, and filtration materials is growing with an increased research focus on polymer composites. In this study, a novel blend of chitosan (CS) and polyethylene oxide (PEO) nanofiber mats was electrospun on titanium (Ti)-coated polyethylene terephthalate (PET) track-etched membranes (TMs) with after-treatment by glutaraldehyde in the vapor phase for enhancing the nanofiber stability by crosslinking. The prepared composite, titanium-coated track-etched nanofiber membrane (TTM-CPnf) was characterized by Fourier transform infra-red (FTIR), water contact angle, and scanning electron microscopy (SEM) analyses. Smooth and uniform CS nanofibers with an average fiber diameter of 156.55 nm were produced from a 70/30 CS/PEO blend solution prepared from 92 wt. % acetic acid and electrospun at 15 cm needle to collector distance with 0.5 mL/h flow rate and an applied voltage of 30 kV on the TTM-CPnf. Short (15 min) and long (72 h)-term solubility tests showed that after 3 h, crosslinked nanofibers were stable in acidic (pH ¼ 3), basic (pH ¼ 13), and neutral (pH ¼ 7) solutions. The crosslinked TTM-CPnf material was biocompatible based on the low mortality of freshwater crustaceans Daphnia magna. The composite membranes comprised of electrospun nanofiber and TMs proved to be biocompatible and may thus be suitable for diverse applications such as dual adsorptionefiltration systems in water treatment.

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Acids ‘generally recognized as safe’ affect morphology and biocompatibility of electrospun chitosan/polyethylene oxide nanofibers

Cited by 36 publications

References 20 publications

Conducting Polymer‐Based Granular Hydrogels for Injectable 3D Cell Scaffolds

Conducting Polymer‐Based Granular Hydrogels for Injectable 3D Cell Scaffolds

Recent Biomedical Approaches for Chitosan Based Materials as Drug Delivery Nanocarriers

Chitosan/PEO nanofibers electrospun on metallized track-etched membranes: fabrication and characterization

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