Acinar Cell Carcinoma of the Pancreas Successfully Treated by En Bloc Resection and Intraperitoneal Chemotherapy for Peritoneal Relapse: A Case Report of a 15-Year Survivor

Kobayashi, Shogo; Ishikawa, Osamu; Ohigashi, Hajime; Yamada, Terumasa; Sasaki, Yukihiro; Imaoka, Shingi; Uehara, Hiroyuki; Nakaizumi, Akihiko; Takenaka, Akemi; Kasugai, Tsutomu

doi:10.1097/00006676-200107000-00016

Cited by 20 publications

(8 citation statements)

References 6 publications

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“…Kitagamy et al (Japanese Cancer Registry) were able to obtain follow-up [18,20]. Few case reports of ACCs (Table 3) also underline the uncertain clinical strategies for this disease which, however, seem to benefit from multi-drug chemotherapy or nonstandardized pancreatic cancer treatment approaches such as the intraperitoneal chemotherapy [21][22][23]. Matos et al interestingly report the longest term survival (67 months) of a patient treated without surgical procedure [19].…”

Section: Discussionmentioning

confidence: 99%

Aggressive approach to acinar cell carcinoma of the pancreas: a single-institution experience and a literature review

Butturini

Pisano

Scarpa

et al. 2010

Langenbecks Arch Surg

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Section: Discussionmentioning

confidence: 99%

Aggressive approach to acinar cell carcinoma of the pancreas: a single-institution experience and a literature review

Butturini

Pisano

Scarpa

et al. 2010

Langenbecks Arch Surg

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“…10 Kobayashi et al reported a case of pancreatic ACC that was successfully treated by an en bloc resection and intraperitoneal chemotherapy for peritoneal relapse. 11 Other authors reported concurrent chemoradiation to be effective for treating pancreatic ACC. [12][13][14] These reports were successful cases, but in most cases of pancreatic ACC, chemotherapy and radiation therapy tend to be not very effective.…”

Section: Discussionmentioning

confidence: 99%

Acinar Cell Carcinoma Arising from an Ectopic Pancreas

et al. 2007

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We herein report a rare case of ectopic pancreatic acinar cell carcinoma (ACC) which presented as a submucosal tumor of the pylorus. A 73-year-old man came to our hospital presenting with epigastralgia. Esophago-gastroduodenal endoscopy showed no mucosal lesions, but a submucosal tumor was observed around the pylorus. Abdominal computed tomography revealed two round masses. One was located in the pylorus, while the other was found between the portal vein and the inferior vena cava. An examination of a biopsy specimen was inconclusive. We diagnosed a gastrointestinal stromal tumor or malignant lymphoma preoperatively, and decided to perform an operation in order to confirm the diagnosis and select the optimal treatment. Intraoperatively, the mass in the pylorus invaded the pancreatic head, and the lymph node in the hepatoduodenal ligament was swollen. We performed a pancreaticoduodenectomy as a radical excision. The resected specimen showed the 7.6 x 4.9-cm size tumor to mainly originate from the pylorus. Histopathologically, the tumor was identified as pancreatic ACC with lymph node metastasis. The tumor cells were labeled by immunohistochemical staining for alpha1-antitrypsin. Because of the tumor location, we considered the tumor to have originated from the ectopic pancreatic tissue in the stomach. This is only the second case of ACC originating from an ectopic pancreas reported in the literature.

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“…9,10 No optimal strategy has yet been determined for patients with synchronous or recurrent liver metastases of ACC. Several reports using chemotherapy with various regimens such as systemic administration, 4 intra-arterial injection, 11 and intraperitoneal administration 12 have documented their effi cacy and the longterm survival for unresectable or recurrent disease. Kitagami et al proposed that chemotherapy is likely to prove useful if ACC is unresectable or recurrent.…”

Section: Discussionmentioning

confidence: 99%

Long-term survival after a repetitive surgical approach in a patient with acinar cell carcinoma of the pancreas and recurrent liver metastases: Report of a case

et al. 2010

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Acinar cell carcinoma is a relatively rare malignant neoplasm, which represents 1%-2% of all pancreatic exocrine tumors. Its prognosis is thought to be poor, especially when it metastasizes to the liver. This report concerns a case of a long-term survivor of metastatic acinar cell carcinoma who was successfully treated with repetitive surgery. A 62-year-old man underwent a distal pancreatectomy for a pancreatic tumor, which was histologically diagnosed as an acinar cell carcinoma. The tumor recurred in the liver three times within 41 months. At the first recurrence, four hepatic lesions appeared 7 months after the initial pancreatectomy and were managed with an extended left hepatic lobectomy and partial liver resection. Thereafter, a solitary nodule in Segment 6 was identified 21 months after the second surgery and was treated with a partial liver resection. A solitary lesion in Segment 8/5 appeared 11 months after the third surgery and was also managed by a partial liver resection. The patient has remained disease-free for 22 months since the last surgery and has survived 65 months since the initial diagnosis. Although no consensus has been reached on surgery for metastatic acinar cell carcinoma, the current case has important implications for establishing an appropriate treatment strategy.

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Acinar Cell Carcinoma of the Pancreas Successfully Treated by En Bloc Resection and Intraperitoneal Chemotherapy for Peritoneal Relapse: A Case Report of a 15-Year Survivor

Cited by 20 publications

References 6 publications

Aggressive approach to acinar cell carcinoma of the pancreas: a single-institution experience and a literature review

Aggressive approach to acinar cell carcinoma of the pancreas: a single-institution experience and a literature review

Acinar Cell Carcinoma Arising from an Ectopic Pancreas

Long-term survival after a repetitive surgical approach in a patient with acinar cell carcinoma of the pancreas and recurrent liver metastases: Report of a case

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