Acinetobacter baumannii

Abstract

Acinetobacter baumannii is an opportunistic bacterial pathogen primarily associated with hospital-acquired infections. The recent increase in incidence, largely associated with infected combat troops returning from conflict zones, coupled with a dramatic increase in the incidence of multidrug-resistant (MDR) strains, has significantly raised the profile of this emerging opportunistic pathogen. Herein, we provide an overview of the pathogen, discuss some of the major factors that have led to its clinical prominence and outline some of the novel therapeutic strategies currently in development.

Efficacy of Artilysin Art-175 against Resistant and Persistent Acinetobacter baumannii

“…The NCTC 13423 or T strain was first isolated in 2003 from a casualty returning from the Iraq war, earning it the nickname Iraqibacter. Despite not having greatly contributed to an increase in A. baumannii infections, it possesses all characteristics of a highly successful outbreak strain and has become a major cause of concern in conflict zones (23,24). In sum, Art-175 shows a good antibacterial activity against all tested A. baumannii strains, independent of the presence of multidrug resistance mechanisms.…”

Identification of Acinetobacter baumannii Serum-Associated Antibiotic Efflux Pump Inhibitors

“…Ventilator-associated pneumonia and bacteremia are the two most severe types of A. baumannii infection, both of which are thought to include dissemination of the organism to visceral organs via the circulatory system (1,2,6,37). For that reason, much effort has been devoted toward defining the cellular components of the organism that modulate growth and persistence in the blood by using human serum as a convenient growth medium for such studies.…”

Molecular Analysis of the Isolates of Acinetobacter baumannii isolated from Tehran Hospitals Using ERIC-PCR Method

“…Phenotypic techniques include evaluation of biochemical characteristics, phage typing, bacteriocin typing, immunoblotting, protein analysis, and identification of antimicrobial resistance patterns (8). These techniques are not powerful enough to identify and differentiate Acinetobacter strains and cannot determine the source and ways of distribution and effective measures for controlling the spread of infection and prevalent isolates (9). In recent years, genotypic techniques using specific molecular markers are used for epidemiological studies and typing of Acinetobacter species.…”