Acinetobacter Infection

Increasing Occurrence of Multidrug-Resistance in Acinetobacter baumannii Isolates From Four German University Hospitals, 2002–2006

“…External quality control involved participation in ring tests. We defined MDR as resistance to three or more classes of recommended drugs [2,11]. If two antibiotics from one class were tested, both needed to be resistant in order to meet the definition.…”

“…Acinetobacter baumannii is a gram-negative organism and is considered as an emerging hospitalacquired pathogen [1,2]. Skin, pharyngeal or faecal colonisation can occur in 1-3% of healthy humans and potentially creates a patientreservoir as a source for A. baumannii infections in hospital environments.…”

Prevalence and diversity of carbapenemases among imipenem-nonsusceptible Acinetobacter isolates in Korea: emergence of a novel OXA-182

“…are frequent causes of a variety of nosocomial infections, including serious diseases such as pneumonia, bacteremia, and meningitis (Munoz-Price and Weinstein, 2008). Carbapenems are β-lactam antibiotics that are highly active even against Gram-negative bacilli producing extended spectrum β-lactamases or hyperproducing AmpC β-lactamases.…”

“…A high colistin resistance rate of 30.6% among A. baumannii isolates from 2 Korean hospitals (Ko et al, 2007) indicated necessity of colistin susceptibility testing in other settings. With a recent increase of multiresistant Acinetobacter isolates in many countries, selection of appropriate antimicrobial agents has become very difficult, resulting in increased patient mortality (Munoz-Price and Weinstein, 2008;Sunenshine et al, 2007).…”

Colonization pressure: a critical parameter in the epidemiology of antibiotic-resistant bacteria

“…In the case of Acinetobacter, however, as with vancomycin-resistant enterococci, persistently contaminated environmental surfaces may also contribute to acquisition risks, and it is uncertain how this interacts with colonization pressure estimates [6,7]. …”