Acinic cell carcinoma of minor salivary gland showing features of high-grade transformation

Ilayaraja, Vadivel; Prasad, Harikrishnan; Anuthama, Krishnamurthy; Sruthi, Ranganath

doi:10.4103/0973-029x.131925

Cited by 12 publications

(8 citation statements)

References 10 publications

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“…In addition, AcCC of minor salivary glands accounts for about 9 % in a SEER database [44]. The trend is also a feature of institutional series [36] and in case reports [45,46]. Whether this relates to a generally decreased proportion of serous acinar cells in normal minor salivary glands, is unknown.…”

Section: Clinical Featuresmentioning

confidence: 99%

Salivary acinic cell carcinoma: reappraisal and update

Poorten

Triantafyllou

Thompson

et al. 2015

Eur Arch Otorhinolaryngol

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Epidemiologic and clinicopathologic features, therapeutic strategies, and prognosis for acinic cell carcinoma of the major and minor salivary glands are critically reviewed. We explore histopathologic, histochemical, electron microscopic and immunohistochemical aspects and discuss histologic grading, histogenesis, animal models, and genetic events. In the context of possible diagnostic difficulties, the relationship to mammary analog secretory carcinoma is probed and a classification is suggested. Areas of controversy or uncertainty, which may benefit from further investigations, are also highlighted.

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Section: Clinical Featuresmentioning

confidence: 99%

Salivary acinic cell carcinoma: reappraisal and update

Poorten

Triantafyllou

Thompson

et al. 2015

Eur Arch Otorhinolaryngol

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“…In addition to these variants, cells in ACC may be granular, clear or vacuolated. Overall, irrespective of cell type, scant mitoses are generally seen [4,5].…”

Section: Introductionmentioning

confidence: 99%

DOG1, alpha-amylase and p63 expression in acinic cell carcinoma of salivary gland; immunohistochemical, clinical and radiological study

Atta¹,

Qahtani²

2015

J Histol Histopathol

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Introduction: Identification of serous acinar differentiation is the basic step for the diagnosis of acinic cell carcinoma (ACC). α-amylase was described to be specific for normal acinar cell but its affinity to malignant counterpart is being contentious. Recently discovered marker anoctamin (DOG1) specific for diagnosis of GISTs has been reported for its efficacy to stain the malignant acinar cells and so, it is being of value in ACC diagnosis. On the other hand, negativity of acinar cells to basal cell marker as p63 will give more pronouncement to ACC diagnosis. Objectives: The study were designed to scrutinize the expression of recent marker DOG1 versus α-amylase in ACC diagnosis. Also to correlate between clinical, radiological, histopathological and immunohistochemical findings in ACC cases. Material and methods: Fourteen cases of ACC were obtained and stained immunohistochemically for DOG1, α-amylase and p63. Clinical data as well as radiological findings were obtained from the patients' file to form correlation with immunostaining results. Results: All ACCs (100%) revealed positivity toward DOG1 staining, 6 (44%) cases out of 14 showed α-amylase positivity, and 1 case (7%) showed focal positivity for p63. No significant correlation was found between clinical, radiological and immunostaining results. Significant correlation was obtained between results of DOG1 and α-amylase with p-value=0.034, also significant correlation was obtained between DOG1 and p63 with p-value=0.02. On the other hand, no significant correlation was obtained between results of both α-amylase and p63 with p-value=0.546. Conclusion: DOG1 has a higher efficacy in the diagnosis of ACC than α-amylase and must be used especially for cases with some conflicts as poor tissue sampling or suspicious cases with other carcinomas especially with carcinomas of clear cell features or having a vacuolated cytoplasm.

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“…3 A revisão dos casos de CCA em glândulas salivares menores nos últimos cinco anos (Tabela 2) mostrou uma maior incidência desses tumores como nódulos sintomáticos principalmente diagnosticados em homens com idade variável de 30 a 78 anos, sendo a mucosa jugal o sítio mais acometido. 3,4,5,6,7,8,9,10,11 Autores N Sexo Idade (Anos)…”

Section: Discussionunclassified

“…2,3,4 O presente trabalho teve como objetivo relatar um caso de CCA originado em glândula salivar menor, onde houve diagnóstico precoce e conduta terapêutica adequada, além de comparar o presente caso com outros relatos de CCA descritos na literatura nos últimos seis anos (2010-2016). [4][5][6][7][8][9][10][11] relato do caso Paciente do sexo feminino, 35 anos de idade, foi encaminhada a uma clínica de Diagnóstico Oral queixando-se de dor espontânea em região esquerda da face. Ao exame clínico nenhum tipo de alteração dentária ou na mucosa oral estava relacionado com a queixa.…”

Section: Introductionunclassified

“…60 Lábio superior Ass. Ilayaraja et al, (10) Aravind et al, (11) Os padrões histológicos parecem não exercer influências no comportamento biológico e prognóstico tumoral. 3 No presente caso, havia predomínio do padrão sólido, além da presença de células claras, o que poderia fazer diagnóstico diferencial com carcinoma mioepitelial ou adenocarcinoma de células claras, no entanto, a expressão imunohistoquímica descrita na Tabela 1 confirma uma diferenciação acinar/ductal (Ck-alto peso molecular e Ck-8) sem a presença de células mioepiteliais (p63 e Actina de músculo liso), que somada com características histopatológicas, confirmou o diagnóstico de CCA.…”

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Um caso raro de Carcinoma de Células Acinares em mucosa oral

Silva

Souza

et al. 2017

Rev. Fac. Odontol. Lins

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Introdução: O carcinoma de células acinares é uma neoplasia epitelial maligna rara de glândulas salivares que afeta predominantemente a glândula parótida na população feminina. Ocorrências menos comuns desta neoplasia são relatadas no palato, seio maxilar, lábios e mucosa jugal. A recorrência desses tumores após cirurgia é de aproximadamente 35% e está relacionada a tumores diagnosticados tardiamente e com presença de metástase no momento do diagnóstico. Objetivo: Relatar um caso raro de um tumor em glândula salivar menor e comparar os achados clínicos com outros casos relatados na literatura. Relato de Caso: Paciente do sexo feminino, 35 anos, apresentou um nódulo doloroso de aproximadamente 2cm em mucosa jugal que foi diagnosticado inicialmente como um schwanoma devido aos seus achados clínicos e radiológicos. Após biópsia incisional, o exame histopatológico e imunoistoquímico revelou um carcinoma de células acinares. Uma Tomografia por emissão de pósitrons não revelou presença metástases. Conclusão: Nódulos submucosos orais podem representar neoplasias malignas e mesmo diante de uma hipótese diagnóstica de tumor benigno, recomenda-se uma biopsia incisional imediata para obtenção de um diagnóstico precoce e conduta terapêutica adequada nesses casos.

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Acinic cell carcinoma of minor salivary gland showing features of high-grade transformation

Cited by 12 publications

References 10 publications

Salivary acinic cell carcinoma: reappraisal and update

Salivary acinic cell carcinoma: reappraisal and update

DOG1, alpha-amylase and p63 expression in acinic cell carcinoma of salivary gland; immunohistochemical, clinical and radiological study

Um caso raro de Carcinoma de Células Acinares em mucosa oral

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