Acinic Cell Carcinoma of the Trachea: Report of a Case

Tsukayama, Shoichi; Omura, Kenji; Kanehira, Eiji; Kawakami, Kazuyuki; Oda, Makoto; Ohtake, Hiroshi; Nonomura, Akitaka; Watanabe, Go

doi:10.1007/s00595-004-2797-2

Cited by 6 publications

(10 citation statements)

References 13 publications

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“…A thorough literature search was performed on PubMed and Google Scholar, using the key words “pulmonary,” “lung,” “tracheal,” “bronchial,” and “acinic cell carcinoma.” On review of the literature, 19 cases were identified (Table 1). 8-23…”

Section: Methodsmentioning

confidence: 99%

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Primary Pulmonary Acinic Cell Carcinoma: A Clinicopathological Study of 6 Cases and Literature Review

Nie

Zhou

et al. 2019

Int J Surg Pathol

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Primary pulmonary acinic cell carcinoma (ACC) is rare. The clinicopathological features are not identical to that of classic ACC that leads to misdiagnosis. In this article, we summarized the clinicopathological features of 25 such cases, including 6 cases in this series and additional 19 cases in the literature. Pulmonary ACCs showed an overwhelming solid growth pattern. The neoplastic cells had eosinophilic granular and clear cytoplasm in most cases and displayed basophilic cytoplasm in only 4 cases. Intratumoral fibrous septa, mitotic figure, necrosis, and psammoma bodies were observed in some cases. Prominent nuclear atypia and perineural invasion might suggest high-grade transformation, metastasis, and recurrence. The tumor cells were strongly positive for CK8/18 and negative for TTF-1, p63, S-100, mammaglobin, MUC5b, MUC5ac, and DOG1. CK7 was exclusively positive for neoplastic cells with ductal differentiation. Of the 25 included cases, 10 cases were initially misdiagnosed. The tumor was prone to involve the right bronchus. The patient outcome was favorable. The accurate diagnosis of primary pulmonary ACC relies on comprehensive evaluation of histological and immunohistochemical features and realization of the difference from classic ACC.

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Section: Methodsmentioning

confidence: 99%

“…14 The neoplastic cells in most cases had eosinophilic granular and clear cytoplasm; only 4 cases displayed basophilic cytoplasm. 11,14,18,21…”

Section: Literature Reviewmentioning

confidence: 99%

Primary Pulmonary Acinic Cell Carcinoma: A Clinicopathological Study of 6 Cases and Literature Review

Nie

Zhou

et al. 2019

Int J Surg Pathol

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“…Symptoms Yr Sex Age Size (cm) Site Therapy Outcome 1 [5] Asymptomatic 1972 M 63 4.2 RLL S A, 22 mo 2 [6] Recurrent pulmonary infections 1976 F 12 0.8 RML, bronchus intermedius S A, 1 yr 3 [7] Three-year history of hemoptysis 1982 M 54 2.2 Trachea S A, 2 yr 4 [8] Persistent cough 1985 M 36 4 RML Unknown Unknown 5 [9] Incidental 1992 F 44 3.5 RML, subpleural S A, 10 yr 6 [9] Incidental 1992 F 48 4 LUL, parenchymal S LF 7 [9] Incidental 1992 F 50 1.7 RML, subpleural S A, 3 yr 8 [9] Persistent cough 1992 M 63 1.2 RML, endobronchial S A, 4 yr 9 [9] Incidental 1992 F 75 1.5 RUL, subpleural S A, 4 yr 10 [10] Dyspnea, cough, stridor 1994 M 31 2 Trachea S A, 8 yr 11 [11] Hemoptysis 1996 M 59 3 Trachea S ND 12 [12] Incidental 1999 M 64 3 LLL, endobronchial S, radiation A, 1.5 yr 13 [13] Incidental 2003 F 30 2 RLL, subpleural S R, 20 mo 14 [14] Incidental 2003 M 70 4 RLL, intraparenchymal S ND 15 [15] Hemoptysis and night sweats 2004 F 4 3 LUL, endobronchial S ND 16 [16] Hoarseness 2004 M 54 5 Trachea S A, 23 mo 17 [17] Persistent cough 2004 M 58 1.5 RML, endobronchial S A, 4 mo 18 [18] Incidental 2005 F 37 3.3 RUL S ND 19 [19] Incidental 2006 M 47 1.8 LLL, endobronchial S A, 1 yr 20 [20] Asymptomatic 2010 M 68 1.8 LLL S, chemotherapy ND 21 [21] Incidental 2011 M 63 5.2 RUL S A 22 [22] Persistent cough 2011 F 55 1.3 RUL S, chemotherapy A, 3 yr 23 [23] Persistent cough 2017 M 31 4.5 RLL, subpleural S ND 24 [24] Persistent cough, hemoptysis 2019 F 10 1.5 LUL S A, 30 mo 25 [24] Persistent cough, chest pain 2019 M 25 2.2 RUL S A, 48 mo 26 [24] Hemoptysis 2019 M 37 1 RLL S A, 8 mo 27 [24] Persistent cough, hemoptysis 2019 F 8 0.4 LML S A, 33 mo 28 [24] Persistent cough, hemoptysis 2019 M 28 1 RML S A, 31 mo 29 [24] Hemoptysis 2019 F 53 1.5 RML S A, 28 mo 30 [25] Persistent cough, hemoptysis 2021 F 27 8.6 RUL, endobronchial S A, 24 mo 31 [26] Persistent…”

Section: Casementioning

confidence: 99%

Primary acinic cell carcinoma of the trachea: A case report and literature review

Yang

Wang

et al. 2023

Medicine

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Rationale: Salivary gland-type acinic cell carcinoma (ACC) is a low-grade malignancy. Primary ACC of the trachea and lungs is rare; here, we describe 1 such case. The histological morphology of tracheal ACC was similar to that of its salivary gland-associated equivalent. Because of its rarity, it is easily misdiagnosed as another type of tracheal or lung tumor. Microscopic analysis of pathological features and immunohistochemistry help diagnose primary ACC of the trachea and lungs. Patient concerns: A 33-year-old female complained of shortness of breath and hemoptysis for 2 years, and reported the symptoms to have aggravated over the last 4 months. The patient was admitted to our hospital for further treatment. Enhanced computed tomography revealed a soft tissue density nodule shadow in the trachea, which was approximately 1.3 × 1.2 cm in size. Diagnoses: Based on the clinical information, morphological features, and immunohistochemistry, the pathological diagnosis was primary ACC of the trachea. Intervention: The tracheal lesion was resected with an electric snare, electrotomy, freezing, and an argon knife using a rigid bronchoscope. Outcomes: The patient’s postoperative course was uneventful. Lessons: It is important to prevent misdiagnosis of this type of tumor as another type of lung tumor. Morphological and immunohistochemical features can be useful in diagnosing primary ACC of the trachea and lungs.

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“…Acinic cell carcinoma (ACC), which follows mucoepidermoid carcinoma, is a secondary common malignant tumor of the salivary gland and predominantly occurs in the parotid gland 1 . ACC also occurs in minor salivary glands at a frequency of approximately 0.3% and occurs rarely in the respiratory tract, including the nose, paranasal sinuses and lower respiratory tract 2–9 . In the lung, ACC develops in the bronchial gland, but primary ACC of the lung is rare, and only 10 cases have been reported so far in the literature 5 .…”

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confidence: 99%

“…1 ACC also occurs in minor salivary glands at a frequency of approximately 0.3% and occurs rarely in the respiratory tract, including the nose, paranasal sinuses and lower respiratory tract. [2][3][4][5][6][7][8][9] In the lung, ACC develops in the bronchial gland, but primary ACC of the lung is rare, and only 10 cases have been reported so far in the literature. 5 Here we report on the unique case of a primary bronchial gland tumor that had histological features of very welldifferentiated ACC containing mucin-filled cystic structures that are usually seen in well-differentiated mucoepidermoid carcinoma.…”

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confidence: 99%

Unique case of pulmonary bronchial gland type tumor with broad spectrum of cell differentiation from the terminal duct–acinar unit to excretory duct

Gamal

Nagashima²,

Kawashima³

et al. 2006

Pathology International

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In the lung, acinic cell carcinoma (ACC) is a rare form of tumor. Reported herein is a unique bronchial gland-type tumor diagnosed as well-differentiated ACC that developed in the B9 bronchus of the left lung. Various immunohistochemical and histochemical staining partly satisfied the diagnosis of ACC. Moreover, this tumor contained various sizes of mucous cysts lined by columnar mucous cells, which produced abundant mucin positive for Alcian blue, which is usually present in mucoepidermoid carcinoma. Therefore, the present case is a unique tumor having a broad spectrum of cell differentiation from the terminal duct--acinar unit to the striated duct and excretory duct. This is the first case of unique bronchial gland-type tumor with mixed histological features of ACC and mucoepidermoid carcinoma.

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Acinic Cell Carcinoma of the Trachea: Report of a Case

Cited by 6 publications

References 13 publications

Primary Pulmonary Acinic Cell Carcinoma: A Clinicopathological Study of 6 Cases and Literature Review

Primary Pulmonary Acinic Cell Carcinoma: A Clinicopathological Study of 6 Cases and Literature Review

Primary acinic cell carcinoma of the trachea: A case report and literature review

Unique case of pulmonary bronchial gland type tumor with broad spectrum of cell differentiation from the terminal duct–acinar unit to excretory duct

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