Acinic cell carcinoma of the breast: A comprehensive review

Ajkunic, Azra; Skenderi, Faruk; Shaker, Nada; Akhtar, Saghir; Lamovec, Janez; Gatalica, Zoran; Vranić, Semir

doi:10.1016/j.breast.2022.10.012

Cited by 14 publications

(22 citation statements)

References 59 publications

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“…Most head and neck AciCC have translocations resulting in upregulation of NR4A3 expression, 177 resulting in positive NR4A3 immunohistochemistry in most cases 168,176 . In contrast, to our knowledge neither NR4A3 rearrangement nor NR4A3 expression has been identified in breast AciCC 171 . NR4A3 rearrangement was not identified by FISH in the one tested case of pulmonary AciCC 16 .…”

Section: Rare or Newly Recognized Primary Pulmonary Salivary Gland‐ty...mentioning

confidence: 61%

“…168,176 In contrast, to our knowledge neither NR4A3 rearrangement nor NR4A3 expression has been identified in breast AciCC. 171 NR4A3 rearrangement was not identified by FISH in the one tested case of pulmonary AciCC. 16 NR4A3 immunohistochemistry was negative in a combined AciCC/carcinoid tumour, 178 and was not performed on any of the reported pure AciCC of the lung.…”

Section: Hyalinizing Clear Cell Carcinomamentioning

confidence: 74%

“…DOG1 was negative in almost all breast AciCC 169 . S100 protein was negative in all pulmonary AciCCs, 16 similar to AciCC in the head and neck, 74,162,170 but in contrast to positive staining in 85%–93% of breast AciCC 171,172 . SOX10 showed heterogenous staining in pulmonary AciCC, 16,19 but was positive in most head and neck AciCC 74 .…”

Section: Rare or Newly Recognized Primary Pulmonary Salivary Gland‐ty...mentioning

confidence: 93%

“…There are limited data for SOX10 in breast AciCC. Lysozyme, amylase, and alpha‐1 antitrypsin/chymotrypsin had greater than 90% sensitivity for breast AciCC, 171,172 but these markers had variable staining or were negative in head and neck AciCC 173–175 . Among pulmonary AciCC, six out of eight carcinomas expressed alpha‐1 antitrypsin/chymotrypsin, 16,19,159,161 one out of five was positive for amylase, 159 and none of the seven cases expressed lysozyme 18,47,159 …”

Section: Rare or Newly Recognized Primary Pulmonary Salivary Gland‐ty...mentioning

confidence: 98%

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Recent developments in the pathology of primary pulmonary salivary gland‐type tumours

Naso,

Roden

2023

Histopathology

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Primary pulmonary salivary gland‐type tumours are rare neoplasms that are thought to arise from seromucinous glands that are located in the submucosa of large airways. These neoplasms have clinical and pathologic features that are distinct from other pulmonary neoplasms. The majority of primary pulmonary salivary gland‐type tumours are malignant, with the most common entities being mucoepidermoid carcinoma, adenoid cystic carcinoma, and epithelial‐myoepithelial carcinoma. Less commonly seen are myoepithelial carcinoma, hyalinizing clear cell carcinoma, acinic cell carcinoma, secretory carcinoma, salivary duct carcinoma, intraductal carcinoma, and polymorphous adenocarcinoma. Benign salivary gland‐type tumours of the lung include pleomorphic adenoma and sialadenoma papilliferum. Morphologic, immunophenotypic, and molecular features of these neoplasms are largely similar to salivary gland tumours elsewhere, and therefore the exclusion of metastatic disease requires clinical and radiologic correlation. However, the differential diagnostic considerations are different in the lung. The distinction of salivary gland‐type tumours from their histologic mimics is important for both prognostication and treatment decisions. Overall, salivary gland type‐tumours tend to have a more favourable outcome than other pulmonary carcinomas, although high‐grade variants exist for many of these tumour types. Recent advances in our understanding of the spectrum of salivary gland‐type tumours reported in the lung and their diversity of molecular and immunohistochemical features have helped to refine the classification of these tumours and have highlighted a few differences between salivary gland‐type tumours of the lung and those primary to other sites.

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Section: Rare or Newly Recognized Primary Pulmonary Salivary Gland‐ty...mentioning

confidence: 61%

Section: Hyalinizing Clear Cell Carcinomamentioning

confidence: 74%

Section: Rare or Newly Recognized Primary Pulmonary Salivary Gland‐ty...mentioning

confidence: 93%

Section: Rare or Newly Recognized Primary Pulmonary Salivary Gland‐ty...mentioning

confidence: 98%

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Recent developments in the pathology of primary pulmonary salivary gland‐type tumours

Naso,

Roden

2023

Histopathology

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“…Apart from the salivary gland, ACC can also occur in the trachea, lungs, mammary gland, and other organs among which primary ACC of the trachea and lung is very rare. [1][2][3] 2. Case presentation…”

Section: Introductionmentioning

confidence: 99%

Primary acinic cell carcinoma of the trachea: A case report and literature review

Yang

Wang

et al. 2023

Medicine

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Rationale: Salivary gland-type acinic cell carcinoma (ACC) is a low-grade malignancy. Primary ACC of the trachea and lungs is rare; here, we describe 1 such case. The histological morphology of tracheal ACC was similar to that of its salivary gland-associated equivalent. Because of its rarity, it is easily misdiagnosed as another type of tracheal or lung tumor. Microscopic analysis of pathological features and immunohistochemistry help diagnose primary ACC of the trachea and lungs. Patient concerns: A 33-year-old female complained of shortness of breath and hemoptysis for 2 years, and reported the symptoms to have aggravated over the last 4 months. The patient was admitted to our hospital for further treatment. Enhanced computed tomography revealed a soft tissue density nodule shadow in the trachea, which was approximately 1.3 × 1.2 cm in size. Diagnoses: Based on the clinical information, morphological features, and immunohistochemistry, the pathological diagnosis was primary ACC of the trachea. Intervention: The tracheal lesion was resected with an electric snare, electrotomy, freezing, and an argon knife using a rigid bronchoscope. Outcomes: The patient’s postoperative course was uneventful. Lessons: It is important to prevent misdiagnosis of this type of tumor as another type of lung tumor. Morphological and immunohistochemical features can be useful in diagnosing primary ACC of the trachea and lungs.

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