Acitretin in erosive penile lichen planus

Abstract

Lichen planus (LP) is an incompletely understood T-cell mediated auto-immune dermatosis. When LP involves the genitalia it may present as painful, pruritic erosions that can be exquisitely tender, causing distress and genitourinary and sexual dysfunction. Management of erosive genital LP is often suboptimal. Despite higher order evidence demonstrating the efficacy of oral acitretin in the management of cutaneous and oral LP, it still features below other immunosuppressive and immunomodulatory therapies in many clinicians' therapeutic ladder. We present a case of severe erosive penile LP, successfully treated with oral acitretin after topical and oral corticosteroids failed to induce remission.

2022 European guideline for the management of balanoposthitis

“…Stinging after initial application may occur and can be minimized by use of emollients. There is still concern about the risk of malignancy in case of continuous long‐term use 42,53,54,55 Topical and oral ciclosporin can be used for erosive disease 50,56,57 (2,C) In severe cases, oral prednisolone or acitretin may be necessary (2,D) 58 Circumcision: May be the treatment of choice for some cases of erosive lichen planus 59 (2,D)…”

Dažādu ādas lichen planus klīniski morfoloģisko apakštipu patoģenētisko mehānismu izpēte. Promocijas darbs

“…nekrozes(Poon et al, 2016) LPP Perifolikulārs un perivaskulārs limfocitārs iekaisums(Rawat et al, 2016) un mata folikulu atveres pildītas ar keratīna masu/korķi(Poblet et al, 2006). Slimības vēlīnās stadijās dominē termāla un perifolikulāra skleroze(Olsen et al, 2003).AktīniskaisPastiprināta melanīna uzkrāšanās dermā(Puri, 2014).PigmentētaisPalielināts daudzums melanofāgu papillārajā dermas slānī(Rieder et al, 2013;Ghorbel et al, 2014).…”