Acitretin Use in Dermatology

Guenther, Lyn; Kunynetz, Rod; Lynde, Charles; Sibbald, R. Gary; Toole, John; Vender, Ronald; Zip, Catherine

doi:10.1177/1203475417733414

Cited by 32 publications

(24 citation statements)

References 50 publications

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“…Oral retinoids, including acitretin and isotretinoin, function through the modulation of IL-6 and IFN-g activity as well as through antiproliferative activity in KCs (Guenther et al, 2017). No mechanistic evidence as to their effect in HS is available.…”

Section: Retinoid Responsive Elementsmentioning

confidence: 99%

A Systematic Review of Promising Therapeutic Targets in Hidradenitis Suppurativa: A Critical Evaluation of Mechanistic and Clinical Relevance

Frew

Marzano

Wolk

et al. 2021

Journal of Investigative Dermatology

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Section: Retinoid Responsive Elementsmentioning

confidence: 99%

A Systematic Review of Promising Therapeutic Targets in Hidradenitis Suppurativa: A Critical Evaluation of Mechanistic and Clinical Relevance

Frew

Marzano

Wolk

et al. 2021

Journal of Investigative Dermatology

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“… 18 Acitretin is an anti-inflammatory second-generation retinoid that is used to treat severe psoriasis; it is a metabolite of etretinate. 19 Almitrine is a drug that stimulates respiratory respiration by activating receptors of carotid bodies. 20 It is used for the treatment of chronic obstructive pulmonary disease, 21 and as such, it is relevant to COVID-19 symptoms.…”

Section: Resultsmentioning

confidence: 99%

The COVID-19 Drug and Gene Set Library

et al. 2020

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In a short period, many research publications that report sets of experimentally validated drugs as potential COVID-19 therapies have emerged. To organize this accumulating knowledge, we developed the COVID-19 Drug and Gene Set Library ( https://amp.pharm.mssm.edu/covid19/ ), a collection of drug and gene sets related to COVID-19 research from multiple sources. The platform enables users to view, download, analyze, visualize, and contribute drug and gene sets related to COVID-19 research. To evaluate the content of the library, we compared the results from six in vitro drug screens for COVID-19 repurposing candidates. Surprisingly, we observe low overlap across screens while highlighting overlapping candidates that should receive more attention as potential therapeutics for COVID-19. Overall, the COVID-19 Drug and Gene Set Library can be used to identify community consensus, make researchers and clinicians aware of new potential therapies, enable machine-learning applications, and facilitate the research community to work together toward a cure.

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“…Acitretin is a retinoid drug that has been wildly used in the treatment of dermatologic diseases such as psoriasis and hidradenitis suppurativa (HS) [123,124,125], which has recently been reported to act as α-secretase enhancer promoting the non-amyloidogenic APP pathway in patients with mild to moderate AD [126]. Its phase II clinical trials (NCT01078168) have recently been completed, showing a significant increase in the cerebrospinal fluid (CSF) soluble alpha-cleaved amyloid precursor protein (APPsα) concentration in patients receiving oral treatment of acitretin over patients receiving the placebo.…”

Section: Drugs For Alzheimer’s Disease Treatmentmentioning

confidence: 99%

Drug Development for Alzheimer’s Disease: Microglia Induced Neuroinflammation as a Target?

Dong

Cheng

et al. 2019

IJMS

113

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Alzheimer’s disease (AD) is one of the most common causes of dementia. Its pathogenesis is characterized by the aggregation of the amyloid-β (Aβ) protein in senile plaques and the hyperphosphorylated tau protein in neurofibrillary tangles in the brain. Current medications for AD can provide temporary help with the memory symptoms and other cognitive changes of patients, however, they are not able to stop or reverse the progression of AD. New medication discovery and the development of a cure for AD is urgently in need. In this review, we summarized drugs for AD treatments and their recent updates, and discussed the potential of microglia induced neuroinflammation as a target for anti-AD drug development.

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Acitretin Use in Dermatology

Abstract: The recommendations in our clinical pathway reflect the current use of acitretin in Canada for severe psoriasis and other disorders of keratinisation.

Cited by 32 publications

References 50 publications

A Systematic Review of Promising Therapeutic Targets in Hidradenitis Suppurativa: A Critical Evaluation of Mechanistic and Clinical Relevance

A Systematic Review of Promising Therapeutic Targets in Hidradenitis Suppurativa: A Critical Evaluation of Mechanistic and Clinical Relevance

The COVID-19 Drug and Gene Set Library

Drug Development for Alzheimer’s Disease: Microglia Induced Neuroinflammation as a Target?

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