“…The selection of steroidal treatment options for acne should be personalized based on the patient's demographics (age and skin of color [SOC]), concurrent clinical conditions, and preferred route of administration. 2,[40][41][42][43][44] Adolescent or Adult Acne Due to safety concerns, the use of spironolactone and COCs is limited in adolescents with acne. 1,45 Spironolactone is recommended only for adolescents with frequent acne breakouts and those who require long-term antibiotics, have contraindications or intolerance to retinoids, or have hyperandrogenism.…”