Introduction: Adolescence is a stage of physical, psychological, and social changes, which determine the personality of the individual, which can be influenced by physical appearance because of alterations in the skin texture of adolescents. Patients with dermatosis have a higher risk of developing depression, anxiety and suicidal ideas. Acne is an important factor for quality of life and affects adolescents both physically and psychosocially. Objective : To determine the factors associated with the repercussions of acne in adolescents in Honduras. Methodology: Analytical cross-sectional study. The Cardiff Acne Disability Index (CADI) scale was used through a questionnaire in Google Forms. Descriptive and analytical statistics were obtained. Results: Of the 3,272 young participants, with respect to quality of life, 25.8% (845) had medium or high repercussions, 5.3% were very depressed by the appearance of their skin in the month prior to filling out the questionnaire. When multivariate analysis was performed, it was found that those who had medium or high repercussions due to acne were women (RPa: 1.33; 95%CI: 1.20-1.48; p-value<0.001), those of indigenous ethnicity (RPa: 1.36; 95%CI: 1.05-1.75; p-value=0.019), those who had scars on the face (RPa: 13.08; 95%CI: 10.02-17.05; p-value<0.001) or those who had the father (RPa: 1.13; 95%CI: 1.01-1.25; p-value=0.031) or siblings with acne (RPa: 1.16; 95%CI: 1.04-1.28; p-value=0.005). Conclusion: It was found that gender, belonging to an indigenous ethnicity, having scars on the face or that having a close relative who had suffered from acne were associated with medium or high repercussions on the quality of life; it is important to take care of acne in this stage of life to avoid repercussions in adulthood.