Acne erythema improvement by long‐pulsed 595‐nm pulsed‐dye laser treatment: A pilot study

Yoon, Ho Joon; Lee, Dong Hun; Kim, Sun Ok; Park, Kyoung Chan; Youn, Sang Woong

doi:10.1080/09546630701646164

Cited by 37 publications

(51 citation statements)

References 25 publications

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“…The result of acne erythema did not demonstrate a significant difference between the treated side and non–treated side of the face, contrasted to the Yoon et al . study in which the result of acne erythema improved significantly in the treated side of the face.…”

Section: Discussioncontrasting

confidence: 83%

Randomized, controlled trial split‐faced study of 595‐nm pulsed dye laser in the treatment of acne vulgaris and acne erythema in adolescents and early adulthood

et al. 2017

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The high prevalence of acne vulgaris in teenagers has increased comorbidities. Lasers offer alternative options for acne treatment because they have rapid action, low systemic adverse effects, and do not require everyday treatment. To study the efficacy and patients' satisfaction of 595-nm pulse dye laser (PDL) treatment of acne vulgaris and acne erythema in adolescents and early adulthood, we designed a blocked-randomized, split-faced 595-nm PDL (fluence 8 J/cm pulse duration 10 ms, spot size 7 mm, 2 session every 2 weeks) study in patients with mild to moderate acne by comparing the laser-treated and non-treated side. The acne lesion counts, acne erythema grading, and acne severity grading were evaluated at baseline and 2, 4, and 8 weeks. Thirty patients were recruited. The results showed no statistically significant difference except the papule count at week 4 which was -1.828 on the treated side and 0.103 on the non-treated side of the face, P-value 0.0018. There was no statistically significant difference of acne severity grading and acne erythema grading between both sides of the face. The mean scores of patients' satisfaction on the laser-treated side were 75, 81, and 81%, respectively. The PDL treatment in this study reveals no significant improvement in acne therapy; however, the patients were satisfied with this laser treatment.

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Section: Discussioncontrasting

confidence: 83%

Randomized, controlled trial split‐faced study of 595‐nm pulsed dye laser in the treatment of acne vulgaris and acne erythema in adolescents and early adulthood

et al. 2017

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“…The MI corresponds qualitatively to the darkness of skin while EI corresponds to the redness or inflammation of skin. Such devices have been used to predict the risk of melanoma skin cancer [40] and as dosimetry feedback during laser treatment of port-wine stains [51] and acne [52]. Recently, hyperspectral imaging in the visible and near-infrared parts of the spectrum has been used to determine the spatial distribution of oxygen saturation in the human skin [12].…”

Section: Skin Properties Measurementmentioning

confidence: 99%

Rapid and accurate estimation of blood saturation, melanin content, and epidermis thickness from spectral diffuse reflectance

Yudovsky

Pilon

2010

Appl. Opt.

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This paper presents a method to determine chromophore concentrations, blood saturation, and epidermal thickness of human skin from diffuse reflectance spectra. Human skin was approximated as a plane-parallel slab of variable thickness supported by a semi-infinite layer corresponding to the epidermis and dermis, respectively. The absorption coefficient was modeled as a function of melanin content for the epidermis and blood content and oxygen saturation for the dermis. The scattering coefficient and refractive index of each layer were found in the literature. Diffuse reflectance spectra between 490 and 620 nm were generated using Monte Carlo simulations for a wide range of melanosome volume fraction, epidermal thickness, blood volume, and oxygen saturation. Then, an inverse method was developed to retrieve these physiologically meaningful parameters from the simulated diffuse reflectance spectra of skin. A previously developed accurate and efficient semi-empirical model for diffuse reflectance of two layered media was used instead of time-consuming Monte Carlo simulations. All parameters could be estimated with relative root mean squared error less than 5% for (i) melanosome volume fraction ranging from 1 to 8%, (ii) epidermal thickness from 20 to 150 µm, (iii) oxygen saturation from 25 to 100%, (iv) blood volume from 1.2 to 10%, and (v) tissue scattering coefficient typical of human skin in the visible part of the 1 spectrum. Similar approach could be extended to other two-layer absorbing and scattering system.

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“…We used the sub‐purpuric setting for the PDL treatment. This setting has been used in trials involving active inflammatory acne patients and demonstrated clinical benefit . With the sub‐purpuric dose, minimal side effects, that is, less painful and erythema and lower risk of developing post inflammatory hyper‐/hypo‐ pigmentation can be achieved as shown in the present study.…”

Section: Discussionmentioning

confidence: 71%

Pulsed‐dye laser as an adjuvant treatment for papulopustular eruptions from epidermal growth factor receptor inhibitors, a randomized blinded split‐faced controlled trial

et al. 2019

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Objectives To investigate the efficacy of pulsed‐dye laser (PDL) as an adjunctive treatment for facial papulopustular eruptions from EGFR inhibitors (EGFRi). Methods Fourteen patients with facial acneiform eruptions were recruited. Half side of the face was randomized to receive PDL treatment while the other side served as a control. The treatments were delivered every 2 weeks for 4 sessions. The patients were seen at baseline, weeks 2, 4, 6, 8, and 10. Erythema index (EI) measured by colorimeter, the papulopustular lesion count and physician global assessment (PGA) were obtained. Patients were allowed to use their standard treatments for their eruptions. Results Both arms had a significant decrease in EI from baseline at each subsequent visit. In the laser treated side, the mean (95%CI) EI decreased from 23.5 (22.24–24.76) at baseline to 16.3 (15.01–17.59) at week 10, while those of the sham were 23.49 (22.23–24.75) to 20.51 (19.22–21.8), respectively. The mean change was significantly lower in the PDL arm from week 4 onwards. The lesion counts in both groups also decreased significantly, but the mean difference between the arms was not different. PGA scores followed the same pattern as EI. Conclusions Adjunctive treatment with PDL was a safe and effective treatment. Lasers Surg. Med. © 2019 Wiley Periodicals, Inc.

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Acne erythema improvement by long‐pulsed 595‐nm pulsed‐dye laser treatment: A pilot study

Abstract: A long pulse duration 595-nm PDL was found to improve acne erythema with minimal discomfort and an increase in skin elasticity.

Cited by 37 publications

References 25 publications

Randomized, controlled trial split‐faced study of 595‐nm pulsed dye laser in the treatment of acne vulgaris and acne erythema in adolescents and early adulthood

Randomized, controlled trial split‐faced study of 595‐nm pulsed dye laser in the treatment of acne vulgaris and acne erythema in adolescents and early adulthood

Rapid and accurate estimation of blood saturation, melanin content, and epidermis thickness from spectral diffuse reflectance

Pulsed‐dye laser as an adjuvant treatment for papulopustular eruptions from epidermal growth factor receptor inhibitors, a randomized blinded split‐faced controlled trial

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