Acne fulminans

Acne Fulminans Induced by Lymecycline in a Patient with Hidradenitis Suppurativa: A Case Report

“…Briefly, according to the literature, the treatment with doxycycline could promote in AF a massive immune reaction against the P. acnes bacterial antigens with subsequent hypersensitivity reaction of types III and IV, similarly to oral isotretinoin [ 7 ]. In addition, a large number of noninflamed macrocomedones may probably represent a “reservoir” of inflammatory mediators that induce acne flare-up after antibiotic treatment [ 1 ].…”

“…It may or may not occur in association with systemic symptoms and has been described very rarely in association with hidradenitis suppurativa (HS). Its onset may be induced by drugs, particularly isotretinoin [ 1 , 2 ]. We present a case of a patient with HS who developed AF following initiation of antibiotic therapy with lymecycline.…”

A Case of Acne Fulminans

“…The extremely painful nodules and ulcerative lesions will crust and heal, leaving severe scars behind ( Greywal et al, 2017 ). According to the literature, no specific laboratory abnormalities are diagnostic of AF ( Dall'Oglio, Puglisi, Nasca, & Micali, 2020 ). The most notable bacterial organism within AF lesions is Propionibacterium acnes ( Dessinioti & Katsambas, 2017 ).…”

“…Medical management of AF needs to be swift to reduce the inflammatory process and decrease the risk of scarring. The treatment significantly differs from severe acne because of the severity of clinical presentation and possible systemic involvement ( Dall'Oglio et al, 2020 ). It is imperative that the clinician complete a thorough history and physical examination.…”

Tumor necrosis factor‐alpha inhibitors and acne fulminans: Friend or foe?

“…Acne fulminans (AF) is an uncommon variant of inflammatory acne with abrupt eruption of painful nodules, pustules, and hemorrhagic ulcerations, often associated with systemic symptoms 1 . Possible causative or precipitating factors of AF include genetic susceptibility, altered immune response, drug therapies, hormones, and viral infections 2 . We report a case of AF in a patient with Crohn disease (CD) worsened by adalimumab, which is considered a second‐line treatment for AF.…”