Acne vulgaris * Commentary: A UK primary care perspective on treating acne

Poyner, T; Cunliffe, Bill

doi:10.1136/bmj.325.7362.475

Cited by 148 publications

(24 citation statements)

References 19 publications

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“…Acne is the most common skin disease in humans, and in its most severe forms it can lead to significant disfigurement and emotional distress. 55 Although a number of factors contribute to the development of acne, there is compelling evidence that oil-producing sebaceous glands play a central role in the pathogenesis of this disease. 56 Agents aimed at inhibiting Hedgehog signaling may thus provide a novel means of reducing sebaceous gland activity and thereby improving acne.…”

Section: Discussionmentioning

confidence: 99%

Hedgehog Signaling Regulates Sebaceous Gland Development

Allen

Grachtchouk

Sheng

et al. 2003

The American Journal of Pathology

115

104

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Epithelial progenitor cells in skin give rise to multiple lineages, comprising the hair follicle, an associated sebaceous gland, and overlying epidermis; however, the signals that regulate sebocyte development are poorly understood. We tested the potential involvement of the Hedgehog pathway in sebaceous gland development using transgenes designed to either block or stimulate Hedgehog signaling in cutaneous keratinocytes in vivo. Whereas inhibition of the Hedgehog pathway selectively suppressed sebocyte development, Hedgehog pathway activation led to a striking increase both in size and number of sebaceous glands. Remarkably, ectopic Hedgehog signaling also triggered the formation of sebaceous glands from footpad epidermis, in regions normally devoid of hair follicles and associated structures. These ectopic sebaceous glands expressed molecular markers of sebocyte differentiation and were functional, secreting their contents directly onto the skin's surface instead of into a hair canal. The Hedgehog pathway thus plays a key role in sebocyte cell fate decisions and is a potential target for treatment of skin disorders linked to abnormal sebaceous gland function, such as acne.

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Section: Discussionmentioning

confidence: 99%

Hedgehog Signaling Regulates Sebaceous Gland Development

Allen

Grachtchouk

Sheng

et al. 2003

The American Journal of Pathology

115

104

View full text Add to dashboard Cite

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“…Whiteheads (small, cream-coloured, dome-shaped papules), red papules, pustules, or cysts may be found with moderate or severe acne. Scars, both those on the skin and emotional scars, can last a lifetime (Oberemok 2002a; Webster 2002). …”

Section: Introductionmentioning

confidence: 99%

“…According to the lesion type, acne can be classified into four main categories: non-inflammatory (purely comedone acne), mild papular, scarring papular, and nodular; the latter three are inflammatory acne lesions (Webster 2002). Besides the obvious skin lesions, acne may produce permanent scarring and have significant psychosocial consequences (Fried 2010; Oberemok 2002).…”

Section: Introductionmentioning

confidence: 99%

Complementary therapies for acne vulgaris

Cao

Yang

Wang

et al. 2015

Cochrane Database of Systematic Reviews

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“…Acne is one of the most common skin diseases in adolescents [1]. The pathogenesis of acne includes ductal hypercornification, enhanced sebaceous gland activity, colonization by Propionibacterium acnes and inflammation [2].…”

Section: Introductionmentioning

confidence: 99%

Higher 17α-Hydroxyprogesterone Levels Aggravated the Severity of Male Adolescent Acne in Northeast China

Wei

Qu²,

Zhu³

et al. 2014

Dermatology

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Background: The relationship between serum hormone levels and adolescent acne is not fully clarified. Objective: To determine the relationship between levels of androstenedione, dehydroepiandrosterone sulfate (DHEA-S), testosterone, estradiol and 17α-hydroxyprogesterone (17-OHP) with adolescent acne in Northeast China. Methods: A transversal study included 242 acne cases and 188 controls. All data were analyzed using SPSS version 17.0. Results: Androstenedione and testosterone levels were significantly higher (p < 0.0001) in the cases than in the control group. In males, the difference in 17-OHP levels was statistically significant (p < 0.0001), as well as between mild and severe acne cases (p = 0.002). The estradiol level was significantly different (p < 0.0001) between cases and controls in females. Conclusion: Higher androstenedione and testosterone levels are significant risk factors in the occurrence of adolescent acne. A higher 17-OHP level aggravates the severity of male adolescent acne, while a higher estradiol level protects females against the onset of adolescent acne.

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Acne vulgaris * Commentary: A UK primary care perspective on treating acne

Cited by 148 publications

References 19 publications

Hedgehog Signaling Regulates Sebaceous Gland Development

Hedgehog Signaling Regulates Sebaceous Gland Development

Complementary therapies for acne vulgaris

Higher 17α-Hydroxyprogesterone Levels Aggravated the Severity of Male Adolescent Acne in Northeast China

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