Acne vulgaris: proliferative cells in sebaceous glands

Plewig, Gerd

doi:10.1111/j.1365-2133.1974.tb06690.x

Cited by 45 publications

(16 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Sebaceous glands function continuously in excreting sebum to the skin surface with an average sebaceous cell transition time of 14 days. [1][2][3] Androgens play an essential role for the stimulation of the size of sebocytes and sebum production as well as keratinocyte proliferation in the ductus seboglandularis and the acroinfundibulum. 4,5 Exogeneous androgen excess or hyperandrogenism are associated with increased sebum production and severe acne.…”

Section: Introductionmentioning

confidence: 99%

Role of FGFR2-signaling in the pathogenesis of acne

Melnik

2009

Dermato-Endocrinology

View full text Add to dashboard Cite

It is the purpose of this review to extend our understanding of the fibroblast growth factor (FGF) receptor-2b-signaling network in the pathogenesis of acne. A new concept of the role of FGFR2b-signaling in dermal-epithelial interaction for skin appendage formation, pilosebaceous follicle homeostasis, comedogenesis, sebaceous gland proliferation and lipogenesis is presented. The FGFR2-gain-of-function mutations in Apert syndrome and unilateral acneiform nevus are most helpful model diseases pointing the way to androgen-dependent dermalepithelial FGFR2-signaling in acne. Androgen-mediated upregulation of FGFR2b-signaling in acne-prone skin appears to be involved in the pathogenesis of acne vulgaris. In organotypic skin cultures, keratinocyte-derived interleukin-1α stimulated fibroblasts to secrete FGF7 which stimulated FGFR2b-mediated keratinocyte proliferation. Postnatal deletion of FGFR2b in mice resulted in severe sebaceous gland atrophy. The importance of FGFR2b in sebaceous gland physiology is further supported by the mode of action of anti-acne agents which have been proposed to attenuate FGFR2b-signaling. Downregulation of FGFR2b-signaling by isotretinoin explains its therapeutic effect in acne. Downregulation of FGFR2b-signaling during the first trimester of pregnancy disturbs branched morphogenesis and explains retinoid embryotoxicity. Insulin-like growth factor-1 (IGF-1), the mediator of growth hormone during puberty, intracts with androgen-dependent FGFR2b-signaling and links androgen-and FGF-mediated signal transduction important in sebaceous gland homeostasis. The search for a follicular defect in the dermalepithelial regulation of growth factor-signaling in acne-prone skin appears to be a most promising approach to clarify the pathogenesis of acne.

show abstract

Section: Introductionmentioning

confidence: 99%

Role of FGFR2-signaling in the pathogenesis of acne

Melnik

2009

Dermato-Endocrinology

View full text Add to dashboard Cite

show abstract

“…The only studies that exist were carried on the skin sebaceous glands, and they present contradictory results regarding the position of their progenitor cells [8,[12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

“…Materials and Methods: Twenty-seven adult rats weighing about 200 g were injected intraperitoneally with a single dose of 0.5 ÌCi [ 3 H]-thymidine/g body weight. Three rats were sacrificed 1 h after injection and 3 rats each on days 3,6,9,12,15,18,21 and 28 after injection. The eyes and eyelids were removed in one piece, fixed in formalin, embedded in paraffin and cut into 5-Ìm-thick vertical sections along the pupillary-optic nerve axis.…”

mentioning

confidence: 99%

Turnover and Migration of Meibomian Gland Cells in Rats’ Eyelids

Olami¹,

Zajicek²,

Cogan³

et al. 2001

Ophthalmic Res

View full text Add to dashboard Cite

Purpose: The object of this study is to determine the velocity and migration course of meibomian gland cells. Materials and Methods: Twenty-seven adult rats weighing about 200 g were injected intraperitoneally with a single dose of 0.5 µCi [³H]-thymidine/g body weight. Three rats were sacrificed 1 h after injection and 3 rats each on days 3, 6, 9, 12, 15, 18, 21 and 28 after injection. The eyes and eyelids were removed in one piece, fixed in formalin, embedded in paraffin and cut into 5-µm-thick vertical sections along the pupillary-optic nerve axis. The sections were dipped in liquid autoradiographic emulsion, exposed for 3 weeks, and stained with HE. Meibomian glands were scanned in the lower eyelid of the left eye using an ocular micrometer grid. In each scan the basement membrane of each acinus served as a point of origin. Along the entire gland two parameters were noted for each nucleus with three grains or more: the distance from the basement membrane (Y) and grain count. Results: This study demonstrates for the first time the exact timing and direction of meibomian gland cell migration. We have shown that the cells migrate from the basement membrane to the center of the acinus at an average rate of 0.62 ± 0.11 µm/day. Cell generation time was an average of 4.1 days. Conclusions: The stem cells of meibomian glands lie at the circumference of each acinus. These cells migrate synchronously with a constant velocity towards the center of the acinus, and are secreted as sebaceous material.

show abstract

“…24 of the 29 mice that completed the study were biopsied 28 d after catheter implantation (time 2). Five mice were biopsied earlier (days 9, 11, 11, 18, and 18) due to mouse morbidity.…”

Section: Resultsmentioning

confidence: 99%

Development of a nude mouse model to study human sebaceous gland physiology and pathophysiology.

Petersen¹,

Zone

Krueger³

1984

J. Clin. Invest.

View full text Add to dashboard Cite

Abstract. Study of human sebaceous gland physiology and pathophysiology is limited by lack of an adequate animal model. This study was designed to develop an animal model using human face skin grafted onto the nude mouse to study human sebaceous glands. Full-thickness human face skin was grafted onto 60 adult male nude mice. 4 wk after grafting, androgens, which are known to stimulate sebaceous glands, were administered to test the system. Androgens were administered to 21 animals by implanted catheters that were filled with testosterone (T) or dihydrotestosterone (DHT). Empty catheters were implanted in 15 control animals. Graft biopsies and blood for androgen levels were oW tained at time 1 (pre-catheter) and time 2 (26 d after catheter implantation). Three assessments were made on each biopsy: sebaceous gland volume, using an image analyzing computer; sebaceous cell size; and sebaceous gland labeling index. 29 mice completed the study through time 2. In the androgen-treated group, T levels (nanogram per milliliter) five times increased to 4.92±0.35, and DHT levels (nanogram per milliliter) increased 50 times to 16.70. In the androgen-treated group, sebaceous gland volume (,um3 X 10-3) increased from 896±194 to 3,233±754 (P < 0.001), sebaceous cell area (.um2) increased from 167±12 to 243±19 (P < 0.001), and labeling index (percentage) increased from 2.7±0.7 to 6.4±0.9 (P < 0.01). In the control group, sebaceous gland volume fell from 1,070±393 to 417±99

show abstract

Acne vulgaris: proliferative cells in sebaceous glands

Cited by 45 publications

References 15 publications

Role of FGFR2-signaling in the pathogenesis of acne

Role of FGFR2-signaling in the pathogenesis of acne

Turnover and Migration of Meibomian Gland Cells in Rats’ Eyelids

Development of a nude mouse model to study human sebaceous gland physiology and pathophysiology.

Contact Info

Product

Resources

About