Acoustic bubble-based drug manipulation: Carrying, releasing and penetrating for targeted drug delivery using an electromagnetically actuated microrobot

Jeong, Jae Yong; Jang, Deasung; Kim, Daegeun; Lee, Dae-Young; Chung, Sang Kug

doi:10.1016/j.sna.2020.111973

Cited by 72 publications

(56 citation statements)

References 43 publications

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“…The appearance of bubble cavitation has brought many serious hazards, such as the generation of noise [1], the destruction of materials [2,3], and the decline of hydraulic mechanical performance [4]. Still, it has provided various benefits as well, for example, medicine [5], petrochemical [6], and emulsion preparation [7]. Bubble collapse near the liquid-liquid interface can also be seen near a seabed covered by crude oil or the interface between soft tissue and body fluid [8]; thus, it is very critical for deep-sea oil production and bioengineering.…”

Section: Introductionmentioning

confidence: 99%

Dynamic Characteristics of Bubble Collapse Near the Liquid-Liquid Interface

Yin

Huang

et al. 2020

Water

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Bubble collapse near the liquid–liquid interface was experimentally studied in this paper, and the dynamic evolution of a laser-induced bubble (generation, expansion, and collapse) and the liquid–liquid interface (dent and rebound) were captured by a high-speed shadowgraph system. The effect of the dimensionless distance between the bubble and the interface on the direction of the liquid jet, the direction of bubble migration, and the dynamics of bubble collapse were discussed. The results show that: (1) The jet generated during bubble collapse always directs toward the denser fluid; (2) bubble collapses penetrate the interface when the bubble is close to the interface; (3) three different shapes of the liquid–liquid interface—that is, a mushroom-shaped liquid column, a spike droplet, and a spherical liquid droplet—were observed.

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Section: Introductionmentioning

confidence: 99%

Dynamic Characteristics of Bubble Collapse Near the Liquid-Liquid Interface

Yin

Huang

et al. 2020

Water

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“…As an attractive external field source, acoustic source can be easily coupled to actuation system to achieve on-demand control over the trajectory and velocity of micro/nanomotors. 14,47 The controllable manipulation can be achieved by modulating the performance of ultrasound, such as switching on/off, frequency and direction. In essence, the acoustic radiation force (ARF) directly induced acoustic control of swimming microrobots' motion.…”

Section: Other Control Approachesmentioning

confidence: 99%

Recent progress on motion control of swimming micro/nanorobots

Cai

et al. 2021

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Swimming micro/nanorobots attract considerable attention due to their considerable promises in various fields ranging from environmental remediation to biomedicine. However, the control system for optimal trajectory and precise localization is an exciting yet challenging for the existing swimming micro/nanorobots. Researchers have used different actuation systems allowing multiple degrees of freedom to actuate swimming microrobots with various motion control methods from well-controlled physicochemical processes to achieve autonomous movement along the gradient of various chemical or physical fields. Furthermore, with the advance of intelligent technology, machine learning strategies have been considered for intelligent control of swimming microrobots. In this paper, we summarized directly manual control and autonomous tactic motion of swimming micro/nanorobots. The application of reinforcement learning in controllable motions of swimming microrobots was also elaborated.

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“…This combined actuation set-up (8a), supplies radiation forces to levitate magnetic agents, which can also orient themselves under magnetic guidance. Furthermore, the previously discussed self-propelling agents like metallic nanorods [110][111][112] and bubble-powered micro-propellers [113][114][115][116] have been re-engineered to accommodate magnetic components during their synthesis. In the former case, tri-metallic nanorods [110,111] and nanoshells [112] have been developed which use the streaming due to their anisotropic profile along with magnetic guidance for directional motion.…”

Section: (I) Magneto-acoustic Actuationmentioning

confidence: 99%

Contactless acoustic micro/nano manipulation: a paradigm for next generation applications in life sciences

2020

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Acoustic actuation techniques offer a promising tool for contactless manipulation of both synthetic and biological micro/nano agents that encompass different length scales. The traditional usage of sound waves has steadily progressed from mid-air manipulation of salt grains to sophisticated techniques that employ nanoparticle flow in microfluidic networks. State-of-the-art in microfabrication and instrumentation have further expanded the outreach of these actuation techniques to autonomous propulsion of micro-agents. In this review article, we provide a universal perspective of the known acoustic micromanipulation technologies in terms of their applications and governing physics. Hereby, we survey these technologies and classify them with regards to passive and active manipulation of agents. These manipulation methods account for both intelligent devices adept at dexterous non-contact handling of micro-agents, and acoustically induced mechanisms for self-propulsion of micro-robots. Moreover, owing to the clinical compliance of ultrasound, we provide future considerations of acoustic manipulation techniques to be fruitfully employed in biological applications that range from label-free drug testing to minimally invasive clinical interventions.

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Acoustic bubble-based drug manipulation: Carrying, releasing and penetrating for targeted drug delivery using an electromagnetically actuated microrobot

Cited by 72 publications

References 43 publications

Dynamic Characteristics of Bubble Collapse Near the Liquid-Liquid Interface

Dynamic Characteristics of Bubble Collapse Near the Liquid-Liquid Interface

Recent progress on motion control of swimming micro/nanorobots

Contactless acoustic micro/nano manipulation: a paradigm for next generation applications in life sciences

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