Acoustic Cluster Therapy (ACT®) enhances accumulation of polymeric micelles in the murine brain

Olsman, Marieke; Mühlenpfordt, Melina; Olsen, Emma Bøe; Torp, Sverre Helge; Kotopoulis, Spiros; Rijcken, Cristianne J.F.; Hu, Qizhi; Thewissen, Mariëlle; Snipstad, Sofie; Davies, Catharina de Lange

doi:10.1016/j.jconrel.2021.07.019

Cited by 12 publications

(5 citation statements)

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“…The focused ultrasound creates reversible BBB permeability enhancement by concentrating acoustic energy on a focal spot and disrupting tight junctions [ 139 ]. The focused ultrasound intensity parameters can be specified in the units of the acoustic power (0.42–1.84 W [ 172 , 173 ]), power density (0.5–1.0 W/cm 2 [ 174 ]), sound pressure (1000 kPa [ 175 ]), peak acoustic pressure (in the range of 0.09–0.80 MPa [ 173 , 176 , 177 ]), and focal acoustic pressure in the brain (0.8 MPa [ 178 ]). The ultrasonic transducer frequency also may be different and varies from 0.5 to 2.7 MHz [ 62 , 176 , 178 , 179 ].…”

Section: Physical Methods Of Histohematic Barriers Permeability Enhan...mentioning

confidence: 99%

“…The ultrasonic transducer frequency also may be different and varies from 0.5 to 2.7 MHz [ 62 , 176 , 178 , 179 ]. A custom-built dual-frequency ultrasound transducer can be applied [ 177 ]. Depending on the ultrasound power and frequency, the maximum NP diameter reaches 100–200 nm for cell-membrane-cloaked liposomes [ 174 ], lipid–polymer hybrid NPs [ 172 ], and PEGylated Au NPs [ 176 ] and about 50–100 nm for polymeric micelles [ 177 ] and sulfur NPs [ 175 ].…”

Section: Physical Methods Of Histohematic Barriers Permeability Enhan...mentioning

confidence: 99%

“…A custom-built dual-frequency ultrasound transducer can be applied [ 177 ]. Depending on the ultrasound power and frequency, the maximum NP diameter reaches 100–200 nm for cell-membrane-cloaked liposomes [ 174 ], lipid–polymer hybrid NPs [ 172 ], and PEGylated Au NPs [ 176 ] and about 50–100 nm for polymeric micelles [ 177 ] and sulfur NPs [ 175 ]. Similar to the source of a magnetic field, the source of local ultrasonic impact will require prompt intervention in the area of interest, since for the impact of ultrasound, it is necessary to provide a continuous medium that conducts acoustic vibrations.…”

Section: Physical Methods Of Histohematic Barriers Permeability Enhan...mentioning

confidence: 99%

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Passing of Nanocarriers across the Histohematic Barriers: Current Approaches for Tumor Theranostics

et al. 2023

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Over the past several decades, nanocarriers have demonstrated diagnostic and therapeutic (i.e., theranostic) potencies in translational oncology, and some agents have been further translated into clinical trials. However, the practical application of nanoparticle-based medicine in living organisms is limited by physiological barriers (blood–tissue barriers), which significantly hampers the transport of nanoparticles from the blood into the tumor tissue. This review focuses on several approaches that facilitate the translocation of nanoparticles across blood–tissue barriers (BTBs) to efficiently accumulate in the tumor. To overcome the challenge of BTBs, several methods have been proposed, including the functionalization of particle surfaces with cell-penetrating peptides (e.g., TAT, SynB1, penetratin, R8, RGD, angiopep-2), which increases the passing of particles across tissue barriers. Another promising strategy could be based either on the application of various chemical agents (e.g., efflux pump inhibitors, disruptors of tight junctions, etc.) or physical methods (e.g., magnetic field, electroporation, photoacoustic cavitation, etc.), which have been shown to further increase the permeability of barriers.

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Section: Physical Methods Of Histohematic Barriers Permeability Enhan...mentioning

confidence: 99%

Section: Physical Methods Of Histohematic Barriers Permeability Enhan...mentioning

confidence: 99%

Section: Physical Methods Of Histohematic Barriers Permeability Enhan...mentioning

confidence: 99%

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Passing of Nanocarriers across the Histohematic Barriers: Current Approaches for Tumor Theranostics

et al. 2023

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“…In vivo studies have reported that the transition from microclusters to large ACT Ò bubbles can be achieved using ultrasound frequencies of 0.5 to 8 MHz (Healey et al 2016;van Wamel et al 2016a;Kotopoulis et al 2017;Bush et al 2020). Although a small, enhanced drug uptake was observed after this first step, a subsequent ultrasound exposure resulted in a considerably increased drug uptake, indicating that both the activation step and the subsequent sonication called the enhancement step are required (van Wamel et al 2016a;Olsman et al 2021). During the enhancement step, the ACT Ò bubbles are exposed to low-frequency (0.3À1.0 MHz) ultrasound at low pressures causing the ACT Ò bubbles to oscillate (Sontum et al 2015;Healey et al 2016).…”

Section: Introductionmentioning

confidence: 99%

“…Mice with subcutaneously growing pancreatic tumors treated with paclitaxel and ACT Ò exhibited reduced tumor growth compared with those treated with paclitaxel alone (Kotopoulis et al 2017). ACT Ò has also been reported to temporarily increase the permeability of the bloodÀbrain barrier, allowing polymeric nanoparticles to enter the brain parenchyma (Aslund et al 2017;Olsman et al 2021). A clinical study has been initiated in which liver metastases of colorectal cancer patients are being treated with standard chemotherapy combined with ACT Ò (ClinicalTrials.gov identifier: NCT04021277).…”

Section: Introductionmentioning

confidence: 99%