When selecting building materials, health and wellbeing are aspects that are frequently neglected. It has been discovered that traditional materials are a source of hazardous emissions that have a negative impact on the health of individuals. On the other hand, Bio-based Building materials are increasingly being used instead of conventional materials as the construction sector aims to be more sustainable. However, these materials’ potential impacts on human health and wellbeing are also a source of worry. As a result, the purpose of this study is to present a comprehensive review of pertinent scientific research, with a focus on comparative studies that shed light on the effects of using bio-based building materials. Considering both positive and negative health effects, with a focus on indoor environment quality, indoor contaminants, and psychological health and well-being. The results highlight the need for more study and provide insightful information about how using bio-based building materials affects individuals’ health and well-being.