Acoustic deprivation modulates central gain in human auditory brainstem and cortex

Hutchison, Peter; Maeda, Hannah; Formby, C.; Small, Brent J.; Eddins, David A.; Eddins, Ann Clock

doi:10.1016/j.heares.2022.108683

Cited by 4 publications

(1 citation statement)

References 90 publications

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“…In gerbils with developmental conductive HL, age-appropriate subcortical, but not cortical responses were recorded to amplitude modulated sounds presented at similar sensation level as in animals with TH116 . More recently, Hutchison et al, (2023)117 recorded subcortical and cortical neurophysiological responses in young adults with TH before, throughout and after fitting them with earplugs. The results indicate an increase in the subcortical response, but a reduction of cortical activity ipsilateral to the deprived ear.…”

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confidence: 99%

Effects of childhood hearing loss on the subcortical and cortical representation of speech

Calcus,

Rosen

2024

Preprint

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Little is known about the effects of childhood mild-to-moderate sensorineural hearing loss (MM HL) on the function of the auditory pathway. We aimed to examine the effect of childhood MM HL and the benefit of frequency-specific amplification on both subcortical and cortical auditory processing, and to relate it to speech-perceptual abilities. We recorded subcortical and cortical responses to speech syllables in nineteen children with congenital MM HL (unamplified and amplified), and sixteen children with normal hearing (unamplified sounds only). Speech perception was measured behaviourally. Congenital HL led to smaller subcortical and cortical responses to unamplified speech sounds. There was a significant benefit of amplification on subcortical and early, but not late, cortical responses, with some effects differing across age. No relationship was found between the neural and behavioural measures. Childhood MM HL affects both subcortical and cortical processing of speech. Amplification mostly benefits subcortical processing of speech in younger children. Childhood HL leads to functional changes in the processing of sounds, with amplification differentially affecting subcortical and cortical levels of the auditory pathway.

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confidence: 99%

Effects of childhood hearing loss on the subcortical and cortical representation of speech

Calcus,

Rosen

2024

Preprint

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Asymmetric hearing thresholds are associated with hyperacusis in a large clinical population

Jahn

Polley

2023

Hearing Research

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Background and Rationale for a Transitional Intervention for Debilitating Hyperacusis

Formby,

Secor,

Cherri

et al. 2024

J Speech Lang Hear Res

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Purpose: This report provides the experimental, clinical, theoretical, and historical background that motivated a patented transitional intervention and its implementation and evaluation in a field trial for mitigation of debilitating loudness-based hyperacusis (LH). Background and Rationale: Barriers for ameliorating LH, which is differentiated here from other forms of hyperacusis, are delineated, including counterproductive management and treatment strategies that may exacerbate the condition. Evidence for hyper-gain central auditory processes as the bases for LH and the associated LH-induced distress and stress responses are presented. This presentation is followed by an overview of prior efforts to use counseling and therapeutic sound as interventional tools for recalibrating the hyper-gain LH response. We also consider previous efforts to use output-limiting sound-protection devices in the management of LH. This historical background lays the foundation for our transitional intervention protocol and its implementation and evaluation in a field trial. Conclusions: The successful implementation and evaluation of a transitional intervention, which we document in the outcomes of a companion proof-of-concept field trial in this issue, build on our prior efforts and those of others to understand, manage, and treat hyperacusis. These efforts to overcome significant barriers and vexing long-standing challenges in the management and treatment of LH, as reviewed here, are the pillars of the transitional intervention and its primary components, namely, counseling combined with protective sound management and therapeutic sound, which we detail in separate reports in this issue.

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Acoustic deprivation modulates central gain in human auditory brainstem and cortex

Cited by 4 publications

References 90 publications

Effects of childhood hearing loss on the subcortical and cortical representation of speech

Effects of childhood hearing loss on the subcortical and cortical representation of speech

Asymmetric hearing thresholds are associated with hyperacusis in a large clinical population

Background and Rationale for a Transitional Intervention for Debilitating Hyperacusis

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