Acoustic Droplet Vaporization and Propulsion of Perfluorocarbon‐Loaded Microbullets for Targeted Tissue Penetration and Deformation

Kagan, Daniel; Benchimol, Michael; Claussen, Jonathan C.; Chuluun-Erdene, Erdembileg; Esener, Sadik C.; Wang, Joseph

doi:10.1002/anie.201201902

Cited by 306 publications

(275 citation statements)

References 43 publications

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“…A new concept of MDV using a.c. magnetic field as the triggering source for cancer theranostics can effectively overcome the drawbacks of traditional ADV and ODV because there is no gas/bone influence of ultrasound or penetration depth limitations of a laser. [18][19][20]44,45 The stimuli-responsive vaporization process to produce microbubbles can substantially enhance ultrasound imaging, which can be further used for ultrasonography-guided magnetic hyperthermia of cancer. Importantly, the trigger by the a.c. magnetic field does not damage normal tissues where only small amount of PFH-HIONs are present.…”

Section: In Vitro and In Vivo Magnetic Field-responsive Ultrasound Immentioning

confidence: 99%

“…Typically, ADV employs acoustic waves to evaporate the liquid droplets. [18][19][20] However, because ultrasound is easily and substantially influenced by gas or bone, the use of ADV is restricted in vascular imaging, cancer detection and drug delivery. ODV uses a laser as the excitation source to induce the vaporization of liquid droplets.…”

Section: Introductionmentioning

confidence: 99%

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Magnetic nanoparticle-promoted droplet vaporization for in vivo stimuli-responsive cancer theranostics

et al. 2016

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The development of efficient strategies for in vivo stimuli-responsive cancer treatment and personalized biomedicine is a great challenge. To overcome the critical issues and limitations of traditional protocols using acoustic droplet vaporization and optical droplet vaporization in stimuli-responsive tumor treatment, we herein report a new strategy, magnetic droplet vaporization (MDV), based on nanobiotechnology, for efficient magnetic field-responsive cancer theranostics. Perfluorohexane (PFH)-encapsulated superparamagnetic hollow iron oxide nanoparticles with a high magnetic-thermal energy transfer capability quickly respond to an external alternating current (a.c.) magnetic field to produce thermal energy and raise the temperature of the surrounding tumor tissue. The encapsulated PFH, with a desirable boiling point of~56°C, can be vaporized to enhance the performance of ultrasound imaging of tumors, as systematically demonstrated both in vitro and in vivo. The magnetic-thermal energy transfer further ablated and removed tumors in mice tumor xenograft models. This unique MDV principle with high versatility and performance is expected to broaden the biomedical applications of nanotechnology and promote clinical translations of intelligent diagnostic and therapeutic modalities, especially for battling cancer.

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Section: In Vitro and In Vivo Magnetic Field-responsive Ultrasound Immentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Magnetic nanoparticle-promoted droplet vaporization for in vivo stimuli-responsive cancer theranostics

et al. 2016

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“…Under ultrasonic irradiation, the PFC droplets are vaporized, leading to the net motion of microbullets towards lamb kidney tissue. Propulsion can be modulated by adjusting external parameters like acoustic pressure, pulse duration or surfactant concentration [131].…”

Section: Ultrasonically-driven Motionmentioning

confidence: 99%

Interplay Between Mechanochemistry and Sonochemistry

Cintas

Cravotto

Barge

et al. 2014

Topics in Current Chemistry

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“…Another external energy source for tubular micromotors is ultrasound. Kagan et al [59] demonstrated that acoustic droplet vaporization can lead to the displacement of perfluorocarbon-loaded microtubes for targeted tissue penetration and deformation.…”

Section: External Stimulimentioning

confidence: 99%

Tubular micromotors: from microjets to spermbots

2014

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In the last decade, it was demonstrated that tubular micromotors are of potential interest for environmental, sensing, and medical applications. Even though catalytic micromotors rely on toxic fuel for their propulsion, many proof-of-concept applications were shown. Currently, the research community of micromotors is searching for biocompatible fuel solutions in order to extend the field of applications to tasks in physiological conditions. This short review gives an overview over the advances in the field of tubular micromotors explaining the different fabrication methods, fuels, and applications. The article points out the utilization of catalytic microjets in sensing, medical, and environmental applications, as well as the journey towards biocompatible tubular motors driven by motile sperm cells.

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Acoustic Droplet Vaporization and Propulsion of Perfluorocarbon‐Loaded Microbullets for Targeted Tissue Penetration and Deformation

Abstract: Acoustic droplet vaporization of perfluorocarbon-loaded microbullets triggered by an ultrasound pulse provides the necessary force to penetrate, cleave, and deform cellular tissue for potential targeted drug delivery and precision nanosurgery.

Cited by 306 publications

References 43 publications

Magnetic nanoparticle-promoted droplet vaporization for in vivo stimuli-responsive cancer theranostics

Magnetic nanoparticle-promoted droplet vaporization for in vivo stimuli-responsive cancer theranostics

Interplay Between Mechanochemistry and Sonochemistry

Tubular micromotors: from microjets to spermbots

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