Acoustic droplet vaporization for therapeutic and diagnostic applications

Kripfgans, Oliver D.; Fowlkes, J. Brian; Miller, Douglas L.; Eldevik, O P; Carson, Paul L.

doi:10.1016/s0301-5629(00)00262-3

Cited by 536 publications

(667 citation statements)

References 27 publications

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“…The DDFP droplet is stabilized in a superheated state by an albumin shell. In vitro studies have elucidated the values of parameters (such as pulse length, pulse amplitude, presence of nucleation sites) for controlling ADV (Kripfgans et al, 2000;Giesecke and Hynynen, 2003;Kripfgans et al, 2004;Lo et al, 2007). Of these, it has also been found that the vaporization threshold decreases with increasing insonification frequency for short insonification pulses.…”

Section: Introduction and Literaturementioning

confidence: 99%

Towards Aberration Correction of Transcranial Ultrasound Using Acoustic Droplet Vaporization

Haworth

Fowlkes

Carson

et al. 2008

Ultrasound in Medicine & Biology

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We report on the first experiments demonstrating the transcranial acoustic formation of stable gas bubbles that can be used for transcranial ultrasound aberration correction. It is demonstrated that the gas bubbles can be formed transcranially by phase-transitioning single, superheated, micron-size, liquid dodecafluoropentane droplets with ultrasound, a process known as acoustic droplet vaporization (ADV). ADV was performed at 550 kHz, where the skull is less attenuating and aberrating, allowing for higher-amplitudes to be reached at the focus. Additionally, it is demonstrated that time-reversal focusing at 1 MHz can be used to correct for transcranial aberrations with a single gas bubble acting as a point beacon. Aberration correction was performed using a synthetic aperture approach and verified by the realignment of the scattered waveforms. Under the conditions described below, time-reversal aberration correction using gas bubbles resulted in a gain of 1.9 ± 0.3 in an introduced focusing factor. This is a small fraction of the gain anticipated from complete transmitreceive of a fully-populated two-dimensional array with sub-wavelength elements.

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Section: Introduction and Literaturementioning

confidence: 99%

Towards Aberration Correction of Transcranial Ultrasound Using Acoustic Droplet Vaporization

Haworth

Fowlkes

Carson

et al. 2008

Ultrasound in Medicine & Biology

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“…Furthermore, owing to their size ( > 1 µm), microbubble effects are limited to within the vascular system. The invention of phase shift perfluorocarbon (PFC) liquid droplets and acoustic droplet vaporization (ADV) provided a method to solve both these problems 25,26 . Liquid droplets of PFCs, often stabilized with albumin, lipids or polymers, provide a long circulating, triggerable contrast agent.…”

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confidence: 99%

Biomedical photoacoustics beyond thermal expansion using triggered nanodroplet vaporization for contrast-enhanced imaging

2012

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since being discovered by Alexander Bell, photoacoustics may again be seeing major resurgence in biomedical imaging. Photoacoustics is a non-ionizing, functional imaging modality capable of high contrast images of optical absorption at depths significantly greater than traditional optical imaging techniques. optical contrast agents have been used to extend photoacoustics to molecular imaging. Here we introduce an exogenous contrast agent that utilizes vaporization for photoacoustic signal generation, providing significantly higher signal amplitude than that from the traditionally used mechanism, thermal expansion. our agent consists of liquid perfluorocarbon nanodroplets with encapsulated plasmonic nanoparticles, entitled photoacoustic nanodroplets. upon pulsed laser irradiation, liquid perfluorocarbon undergoes a liquid-to-gas phase transition generating giant photoacoustic transients from these dwarf nanoparticles. once triggered, the gaseous phase provides ultrasound contrast enhancement. We demonstrate in phantom and animal studies that photoacoustic nanodroplets act as dualcontrast agents for both photoacoustic and ultrasound imaging through optically triggered vaporization.

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“…It has been known for more than 15 years beginning with a literature by Apfel, who described that a technically designed PFC nanoparticles can transform into microbubbles in the condition of the application of acoustic waves [32]. The name "acoustic droplet vaporization" was given in 2000 by Kripfgans [8]. From then award, ADV has been profoundly investigated in the group works of Michigan University with albumin coated perfluoropentane (PFP) nanoparticles, which illustrated substantially applications PFC nanoparticles with ADV in terms of drug delivery, thrombolysis, and gas embolism, etc.…”

Section: The Machanism Of Vaporization In Pfc Nanoparticlesmentioning

confidence: 99%

“…However, the poor quality on imaging and diagnosing of ultrasonography seriously retards further development of its abilities on the detection of diseases in the early stages, particularly for diagnosing tumors. Fortunately, the microbubbles as a contrast agent (CA) have dramatically enhanced diagnostic capabilities of ultrasonography due to their high acoustic impedance for considerable improvement in echogenic properties [6][7][8][9]. But the relatively large size of microbubbles (typically two to ten micrometers) does not permit successful extravasation into tumor tissues as a result of the fact that the largest pores existing in the microcirculations of tumors are no more than 700 nanometers [10].…”

Section: Introductionmentioning

confidence: 99%

Phase-transition Perfluorocarbon Nanoparticles for Ultrasound Molecular Imaging and Therapy

Xu¹,

Cao²,

Xu³

et al. 2015

Nano BioMed ENG

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Recently, the advances in perfluorocarbon nanoparticles have been introduced to expand the diagnostic and therapeutic capability of ultrasound molecular imaging, a non-invasive diagnostic imaging, which passed from robust anatomical presentation to detection of physiological processes and recognition of specific tissue epitopes at the cellular level. The good properties of perfluorocarbon nanoparticles, such as nontoxicity, small size, phase-shift capability, etc., have been resulted in tremendous potential prospects in clinical application. Herein, this review focuses on the mechanisms of perfluorocarbon nanoparticles in terms of phase transition and ultrasonic theranostic. And the potential applications of perfluorocarbon nanoparticles in ultrasound medicine are also discussed.

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Acoustic droplet vaporization for therapeutic and diagnostic applications

Cited by 536 publications

References 27 publications

Towards Aberration Correction of Transcranial Ultrasound Using Acoustic Droplet Vaporization

Towards Aberration Correction of Transcranial Ultrasound Using Acoustic Droplet Vaporization

Biomedical photoacoustics beyond thermal expansion using triggered nanodroplet vaporization for contrast-enhanced imaging

Phase-transition Perfluorocarbon Nanoparticles for Ultrasound Molecular Imaging and Therapy

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