2021
DOI: 10.1016/j.ijpharm.2021.120927
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Acoustic drug delivery to the maxillary sinus

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Cited by 17 publications
(12 citation statements)
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“…Drug delivery to the sinuses is not only influenced by pulsation parameters of the applied aerosol flow, but also influenced by the breathing patterns, size of the aerosol particles, how the nebulizer is connected to the nose (inclination of the nosepiece) and the anatomy of the nasal airway itself (26)(27)(28). Last-mentioned could be shown by Hosseini and Golshahi in anatomical 3D printed nasal airway models of 2-, 5-and 50-year old human subjects (29).…”
Section: Discussionmentioning
confidence: 96%
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“…Drug delivery to the sinuses is not only influenced by pulsation parameters of the applied aerosol flow, but also influenced by the breathing patterns, size of the aerosol particles, how the nebulizer is connected to the nose (inclination of the nosepiece) and the anatomy of the nasal airway itself (26)(27)(28). Last-mentioned could be shown by Hosseini and Golshahi in anatomical 3D printed nasal airway models of 2-, 5-and 50-year old human subjects (29).…”
Section: Discussionmentioning
confidence: 96%
“…Similarly, positive results could also be achieved by nebulizers using a pulsation of 100 Hz ( 25 , 26 ). Pourmehran et al tried to maximize drug deposition in a single-sided maxillary sinus model by optimally suit frequency, amplitude, and flow rate of applied 12 μm aerosol particles by controlled repeated measurements ( 27 ). They were able to increase drug delivery by 75-fold when using a frequency of 328 Hz with an amplitude of 126 dB re 20 μPa and a flow rate of 0.267 ml/min showing that further developments in nebulization devices could have the opportunity to substantially improve topical drug delivery.…”
Section: Discussionmentioning
confidence: 99%
“…It is also worth mentioning that the nasal cavity geometry selected for this study does not contain sinuses [ 22 ]. To increase the realism of the numerical simulation, influences of the sinuses on airflow and drug particle trajectories as well as the targeted delivery efficiency will be investigated in the future.…”
Section: Discussionmentioning
confidence: 99%
“…Other factors that can influence drug delivery efficiency include the particle diameter, injection angle, inhalation flow rate, injection velocity magnitude, and acoustic wave [ 15 , 16 , 22 ]. When targeted injection and external fields are introduced, those parameters mentioned above must be also optimized.…”
Section: Introductionmentioning
confidence: 99%
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