Recent years have seen a resurgence of nuclear power worldwide, with interest in extending the operating life of the approximately 436 reactors currently in service (as of March, 2012), 61 new reactors being constructed, and as many as 162 under consideration. Renewed worldwide interest in nuclear power has been somewhat tempered by the March 2011 incident at Fukushima Dai-ichi in Japan. However, nuclear power is still considered a key element in meeting future worldwide sustainable energy, energy security, and emissions goals. Currently, three separate thrusts to safe and economical nuclear power development for energy security are being pursued in the United States: (i) longer term operation for the legacy fleet, from 40-60 and possibly 60-80 years; (ii) near-term new nuclear plants with a 60-year design life; and (iii) small modular reactors, which are expected to employ light water reactor technology at least in the medium term. Within these activities, attention is turning to enhanced methods for plant component and structural health management.The operating U.S. fleet includes 104 light water reactors. In addition, there are now (as of May 2012) four new nuclear power plants (AP-1000 plants) under construction in the United States, and two delayed plants are being completed by the Tennessee Valley Authority. There is also interest in the United States in small modular reactors (SMRs), which could be easier to match to existing grid infrastructure and which could replace aging coal fired plants. The current low price for natural gas presents a challenge to the economics of nuclear power, at least in the short term; however, some recent studies have demonstrated that nuclear generation will be competitive in the longer term (at least in some markets) when anticipated escalation in gas prices and the cost of building, operating, and maintaining gas-fired plants are considered over those same time periods.This report reviews the current state of the art of prognostics and health management (PHM) for nuclear power systems and related technology currently applied in field or under development in other technological application areas, as well as key research needs and technical gaps for increased use of PHM in nuclear power systems. The historical approach to monitoring and maintenance in nuclear power plants (NPPs), including the Maintenance Rule for active components and Aging Management Plans for passive components, are reviewed. An outline is given for the technical and economic challenges that make PHM attractive for both legacy plants through Light Water Reactor Sustainability (LWRS) and new plant designs. There is a general introduction to PHM systems for monitoring, fault detection and diagnostics, and prognostics in other, non-nuclear fields. The state of the art for health monitoring in nuclear power systems is reviewed. A discussion of related technologies that support the application of PHM systems in NPPs, including digital instrumentation and control systems, wired and wireless sensor techno...