Acoustic emission of pharmaceutical powders during compaction

Serris, Eric; Périer-Camby, Laurent; Thomas, Gérard; Desfontaines, Marie; Fantozzi, Gilles

doi:10.1016/s0032-5910(02)00174-2

Cited by 43 publications

(25 citation statements)

References 4 publications

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“…The PAT framework encourages and advises the use of modern measurement and monitoring approaches such as the acoustic emission method (18,19), acoustic and ultrasonic characterization techniques (20)(21)(22)(23)(24), the near-infrared sensing (25), light-induced fluorescence characterization (26), Terahertz pulsed spectroscopy (27), laser-induced breakdown spectroscopy (28), X-ray fluorescence method (15), and Raman spectroscopy (29) for characterization and monitoring of tablets to ensure product quality by using on-, in-, and/or at-line measurements and through timely measurements (i.e., during processing) of critical quality and performance attributes of raw and in process materials and unit operations. The effectiveness of air-coupled acoustic technique, using an aircoupled excitation source and laser interferometric detection, has been demonstrated for the nondestructive characterization of the critical mechanical properties and coating thickness of enteric-coated monolayer tablets (21,22).…”

Section: Introductionmentioning

confidence: 99%

Mechanical Property Characterization of Bilayered Tablets using Nondestructive Air-Coupled Acoustics

Akseli

Dey²,

Cetinkaya

2010

AAPS PharmSciTech

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Abstract. A noncontact/nondestructive air-coupled acoustic technique to be potentially used in mechanical property determination of bilayer tablets is presented. In the reported experiments, a bilayer tablet is vibrated via an acoustic field of an air-coupled transducer in a frequency range sufficiently high to excite several vibrational modes (harmonics) of the tablet. The tablet vibrational transient responses at a number of measurement points on the tablet are acquired by a laser vibrometer in a noncontact manner. An iterative computational procedure based on the finite element method is utilized to extract the Young's modulus, the Poisson's ratio, and the mass density values of each layer material of a bilayer tablet from a subset of the measured resonance frequencies. For verification purposes, a contact ultrasonic technique based on the time-of-flight data of the longitudinal (pressure) and transverse (shear) acoustic waves in each layer of a bilayer tablet is also utilized. The extracted mechanical properties from the air-coupled acoustic data agree well with those determined from the contact ultrasonic measurements. The mechanical properties of solid oral dosage forms have been shown to impact its mechanical integrity, disintegration profile and the release rate of the drug in the digestive tract, thus potentially affecting its therapeutic response. The presented nondestructive technique provides greater insight into the mechanical properties of the bilayer tablets and has the potential to identify quality and performance problems related to the mechanical properties of the bilayer tablets early on the production process and, consequently, reduce associated cost and material waste.

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Section: Introductionmentioning

confidence: 99%

Mechanical Property Characterization of Bilayered Tablets using Nondestructive Air-Coupled Acoustics

Akseli

Dey²,

Cetinkaya

2010

AAPS PharmSciTech

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“…The use of acoustic techniques [2,3] or other relevant techniques (e.g., NIR [4][5][6][7][8][9], acoustic emission [10][11][12][13], light-induced fluorescence [14]) has been documented to enhance process knowledge during tableting. Furthermore, the ability to determine in real time whether compacts possess adequate mechanical strength and structural integrity is important for the assurance of product quality (e.g., reduction of capping and lamination).…”

Section: Introductionmentioning

confidence: 99%

Real-time Acoustic Elastic Property Monitoring of Compacts During Compaction

2008

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A nondestructive, real-time acoustic technique for determining elastic properties of compacts during compaction is presented. An acoustic time-of-flight study was conducted, and the extraction of the linear elastic properties of calcium carbonate compacts was demonstrated. To verify the results of the acoustic experiments, a uniaxial compaction investigation was also carried out using a computer-controlled press with an instrumented die. Good agreement between linear elastic properties determined using both acoustic experiments and compaction force-displacement data was observed. This technique has the potential to be used as a real-time compaction monitoring tool.

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“…Such procedures would be consistent with a new quality concept which is transforming "quality-by-inspection" to the desired "quality-by-design," and could reduce risks of quality and regulatory concerns while improving manufacturing efficiency [14]. PAT encourages the use of online techniques (e.g., acoustic emission [15,16], near-infrared spectroscopy [17], lightinduced fluorescence [18], terahertz spectroscopy [19], laser-induced breakdown spectroscopy [20], X-ray fluorescence [21], Fourier transform infrared spectroscopy [22] and acoustic techniques [8][9][10][11]23]) to monitor tabletting unit operations and to characterize final products with the goal of ensuring final product quality.…”

Section: Introductionmentioning

confidence: 99%

Acoustic Testing and Characterization Techniques for Pharmaceutical Solid Dosage Forms

Akseli

Cetinkaya

2008

J Pharm Innov

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The mechanical state of a drug tablet is an important factor in its physical form and therapeutic function. In recent years, a strong need for new technologies for faster and more reliable quality assurance has often been voiced by both regulators and manufacturers. In the current study, a novel air-coupled acoustic technique is demonstrated as a noncontact/nondestructive method for mechanical characterization and coating thickness determination of tablets. For verification purposes, a contact ultrasonic scheme is employed. Applications of the technique in solid dosage form characterization and process monitoring applications and its role as a potential PAT tool are discussed.

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Acoustic emission of pharmaceutical powders during compaction

Cited by 43 publications

References 4 publications

Mechanical Property Characterization of Bilayered Tablets using Nondestructive Air-Coupled Acoustics

Mechanical Property Characterization of Bilayered Tablets using Nondestructive Air-Coupled Acoustics

Real-time Acoustic Elastic Property Monitoring of Compacts During Compaction

Acoustic Testing and Characterization Techniques for Pharmaceutical Solid Dosage Forms

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