Acoustic metamaterials-driven transdermal drug delivery for rapid and on-demand management of acute disease

Xu, Junhua; Cai, Hongwei; Wu, Zhuhao; Li, Xiang; Tian, Chunhui; Ao, Zheng; Niu, Vivian C.; Xiao, Xiao; Jiang, Lei; Khodoun, Marat; Rothenberg, Marc E.; Chen, Jun; Lee, Luke P.; Guo, Feng

doi:10.1038/s41467-023-36581-2

Cited by 59 publications

(31 citation statements)

References 32 publications

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“…Metamaterials with multilayered and multilevel microstructures exhibit distinctive properties that are progressively applied in biomedical fields, including wearable stretchable sensors, [ 48 ] and transdermal drug delivery systems. [ 49 ] However, the synthetic limitations, such as size control, remain significant challenges for the development of well‐defined nano‐metamaterials as cutting‐edge imaging probes for biomedical imaging applications. As a result, despite nano‐metamaterial is theoretically a highly promising candidate for MRI, practical MRI applications using nano‐metamaterial are extremely scarce.…”

Section: Mri Application Of Nano‐metamaterialsmentioning

confidence: 99%

Nano‐Metamaterial: A State‐of‐the‐Art Material for Magnetic Resonance Imaging

Wang

et al. 2023

Small Science

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Metamaterials are artificially designed materials with multilevel‐ordered microarchitectures, which exhibit extraordinary properties not occurring in nature, and their applications have been widely exploited in various research fields. However, the progress of metamaterials for biomedical applications is relatively slow, largely due to the limitations in the size tailoring. When reducing the maximum size of metamaterials to nanometer scale, their multilevel‐ordered microarchitectures are expected to obtain superior functions beyond conventional nanomaterials with single‐level microarchitectures, which will be a prospective candidate for the next‐generation diagnostic and/or therapeutic agents. Here, a forward‐looking discussion on the superiority of nano‐metamaterials for magnetic resonance imaging (MRI) according to the imaging principles, which is attributed to the unique periodic arrangement of internal multilevel structural units in nano‐metamaterials, is presented. Moreover, recent advances in the development of nano‐metamaterials for high‐performance MRI are introduced. Finally, the challenges and future perspectives of nano‐metamaterials as promising MRI contrast agents for biomedical applications are briefly commented.

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Section: Mri Application Of Nano‐metamaterialsmentioning

confidence: 99%

Nano‐Metamaterial: A State‐of‐the‐Art Material for Magnetic Resonance Imaging

Wang

et al. 2023

Small Science

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“…In addition, this patch also possesses convenient and noninvasive advantages, making it suitable for acute disease therapy for personalized medicine. [145]…”

Section: External Stimuli In Biohybrid Systemsmentioning

confidence: 99%

“…Adapted with permission. [145] Copyright 2023, Springer Nature. RESPONSIVE MATERIALS -13 of 24 biological components to overcome the limitations of artificial systems in efficiency, accuracy, and functionality.…”

Section: Bioactuators and The Applicationsmentioning

confidence: 99%

“…(d) An acoustic‐controlled hydrogel microneedle patch can precisely program releasing active drugs and promote transdermal drug absorption. Adapted with permission [145] . Copyright 2023, Springer Nature.…”

Section: Responsive Bioactuators Based On Living Cell‐laden Hydrogelsmentioning

confidence: 99%

“…By manupulating the acoustic signals, the drug dose could be controlled on demand. In addition, this patch also possesses convenient and noninvasive advantages, making it suitable for acute disease therapy for personalized medicine [145] …”

Section: Responsive Bioactuators Based On Living Cell‐laden Hydrogelsmentioning

confidence: 99%

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Living cell‐laden hydrogels: Unleashing the future of responsive biohybrid systems

Hu,

Lei,

et al. 2023

Responsive Materials

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Responsive biohybrid systems have the potential to overcome limitations of both natural and artificial machines in terms of efficiency, accuracy, and functionality. As functional units, living cells act as bricks for building biohybrid machines, where the extracellular matrix mimics hydrogels to act as ideal biological concrete. Combining living cells with hydrogels offers unique advantages in simulating human tissues or organs, which unleashes the future of biohybrid systems, and thus has attracted extensive attention. Herein, recent progress in cell‐laden hydrogel‐based responsive biohybrid systems is summarized to provide a basic understanding of how these systems are built from the bottom up and how to achieve the complex functions. This review focuses on advanced manufacturing technologies for responsive biohybrid systems, including laden cells in hydrogel matrices, three‐dimensional bioprinting, and microfluidic manufacturing. Subsequently, the innovative applications of these works, including actuators, sensors, and engineered functional materials, are presented, along with different triggering mechanisms that are highlighted. Finally, the current challenges and future opportunities in the field are addressed. This review provides a unique perspective and is hoped to inspire fields such as biohybrid technologies, soft robots, and tissue engineering.

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Metastructure “Trap” Coating by Acoustic Confinement Effect for Antibacterial Sonothermal Therapy

Guan,

Chen,

Zhang

et al. 2024

Adv Funct Materials

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Antibacterial sonothermal therapy (ASTT) is attractive for treating implant‐associated infection, which addresses the limitations of poor penetration of photothermal therapy. However, achieving implant surface‐specific ultrasound heating is incredibly challenging. Inspired by the porous acoustic metastructure in noise reduction, the acoustic metastructure would be a new strategy for attaining ASTT. Herein, an “acoustic confinement effect” is proposed to “trap” ultrasound for the metastructure TiO2 porous coating on titanium implants. The metastructure coating accomplishes specific acoustic absorption and efficient acoustic‐to‐thermal conversion, surpassing the non‐specific heating of conventional coatings. The theoretical calculation and experiment of metastructure porous coating prove the acoustic‐to‐thermal conversion mechanism, which is also validated in metastructure porous coatings on medical polyetheretherketone, indicating it is universal. Excitingly, this acoustic metastructure “trap” can capture bacteria and local sonothermal enhancement, exhibiting superior ASTT antibacterial rates (S. aureus, 99.69%; E. coil, 99.58%) at low‐power ultrasound. In addition, the metastructure TiO2 coating mimics human bone and demonstrates outstanding osseointegration. This study sheds substantial light on developing the acoustic responsive surface, broadening a new direction of acoustic metamaterials in medical applications.

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Acoustic metamaterials-driven transdermal drug delivery for rapid and on-demand management of acute disease

Cited by 59 publications

References 32 publications

Nano‐Metamaterial: A State‐of‐the‐Art Material for Magnetic Resonance Imaging

Nano‐Metamaterial: A State‐of‐the‐Art Material for Magnetic Resonance Imaging

Living cell‐laden hydrogels: Unleashing the future of responsive biohybrid systems

Metastructure “Trap” Coating by Acoustic Confinement Effect for Antibacterial Sonothermal Therapy

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