Acoustic parameters of speech: Lack of correlation with perceptual and questionnaire‐based speech evaluation in patients with oral and oropharyngeal cancer treated with primary surgery

Dwivedi, Raghav C.; Rose, S. St.; Chisholm, Edward J.; Clarke, Peter; Kerawala, Cyrus; Nutting, Christopher M.; Rhys‐Evans, Peter; Kazi, Rehan; Harrington, Kevin

doi:10.1002/hed.23956

Cited by 10 publications

(15 citation statements)

References 11 publications

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“…Among the 22 studies, 10 include more than 20 patients, and also 10 include between 2 and 18 subjects . Two articles do not report the number of subjects involved in the acoustic analysis .…”

Section: Resultsmentioning

confidence: 99%

“…Six studies (27%) include both patients treated for cancer of the oral cavity and patients treated for oropharynx cancer …”

Section: Resultsmentioning

confidence: 99%

“…Regarding the size of the tumor, 12 studies (54%) include smaller tumors (T1 + T2) than large ones . Three studies (14%) focus on larger tumors (T3 + T4) .…”

Section: Resultsmentioning

confidence: 99%

“…Of the 22 included studies, 20 (91%) address surgically treated patients. Among them, surgery was carried out exclusively (with no reported information about complementary treatment) in 14 studies, including seven surgical reconstructions . Surgery was combined with other treatment methods such as radiotherapy or chemotherapy in six studies .…”

Section: Resultsmentioning

confidence: 99%

“…The main languages spoken by the subjects and thus constituting the speech sample are English (including American English and Canadian English) and Dutch in four studies, respectively . The remaining studies are all carried out in different languages: French, Portuguese, German, Finnish, Hindi, Japanese, and Korean .…”

Section: Resultsmentioning

confidence: 99%

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Effects of oral and oropharyngeal cancer on speech intelligibility using acoustic analysis: Systematic review

et al. 2019

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Background The development of automatic tools based on acoustic analysis allows to overcome the limitations of perceptual assessment for patients with head and neck cancer. The aim of this study is to provide a systematic review of literature describing the effects of oral and oropharyngeal cancer on speech intelligibility using acoustic analysis. Methods Two databases (PubMed and Embase) were surveyed. The selection process, according to the preferred reporting items for systematic reviews and meta‐analyses (PRISMA) statement, led to a final set of 22 articles. Results Nasalance is studied mainly in oropharyngeal patients. The vowels are mostly studied using formant analysis and vowel space area, the consonants by means of spectral moments with specific parameters according to their phonetic characteristic. Machine learning methods allow classifying “intelligible” or “unintelligible” speech for T3 or T4 tumors. Conclusions The development of comprehensive models combining different acoustic measures would allow a better consideration of the functional impact of the speech disorder.

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Section: Resultsmentioning

confidence: 99%

“…Six studies (27%) include both patients treated for cancer of the oral cavity and patients treated for oropharynx cancer …”

Section: Resultsmentioning

confidence: 99%

“…Regarding the size of the tumor, 12 studies (54%) include smaller tumors (T1 + T2) than large ones . Three studies (14%) focus on larger tumors (T3 + T4) .…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Effects of oral and oropharyngeal cancer on speech intelligibility using acoustic analysis: Systematic review

et al. 2019

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Data mining of an acoustic biomarker in tongue cancers and its clinical validation

et al. 2021

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The promise of speech disorders as biomarkers in clinical examination has been identified in a broad spectrum of neurodegenerative diseases. However, to the best of our knowledge, a validated acoustic marker with established discriminative and evaluative properties has not yet been developed for oral tongue cancers. Here we cross‐sectionally collected a screening dataset that included acoustic parameters extracted from 3 sustained vowels /ɑ/, /i/, /u/ and binary perceptual outcomes from 12 consonant‐vowel syllables. We used a support vector machine with linear kernel function within this dataset to identify the formant centralization ratio (FCR) as a dominant predictor of different perceptual outcomes across gender and syllable. The Acoustic analysis, Perceptual evaluation and Quality of Life assessment (APeQoL) was used to validate the FCR in 33 patients with primary resectable oral tongue cancers. Measurements were taken before (pre‐op) and four to six weeks after (post‐op) surgery. The speech handicap index (SHI), a speech‐specific questionnaire, was also administrated at these time points. Pre‐op correlation analysis within the APeQoL revealed overall consistency and a strong correlation between FCR and SHI scores. FCRs also increased significantly with increasing T classification pre‐operatively, especially for women. Longitudinally, the main effects of T classification, the extent of resection, and their interaction effects with time (pre‐op vs. post‐op) on FCRs were all significant. For pre‐operative FCR, after merging the two datasets, a cut‐off value of 0.970 produced an AUC of 0.861 (95% confidence interval: 0.785–0.938) for T3‐4 patients. In sum, this study determined that FCR is an acoustic marker with the potential to detect disease and related speech function in oral tongue cancers. These are preliminary findings that need to be replicated in longitudinal studies and/or larger cohorts.

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Speech Deficits Associated with Oral and Oropharyngeal Carcinomas

Constantinescu

Rieger

2019

Clinical Care and Rehabilitation in Head and Neck Cancer

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Acoustic parameters of speech: Lack of correlation with perceptual and questionnaire‐based speech evaluation in patients with oral and oropharyngeal cancer treated with primary surgery

Abstract: Acoustic evaluation modalities have no clear role in the management of patients with oral cavity and oropharyngeal cancer.

Cited by 10 publications

References 11 publications

Effects of oral and oropharyngeal cancer on speech intelligibility using acoustic analysis: Systematic review

Effects of oral and oropharyngeal cancer on speech intelligibility using acoustic analysis: Systematic review

Data mining of an acoustic biomarker in tongue cancers and its clinical validation

Speech Deficits Associated with Oral and Oropharyngeal Carcinomas

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