Acoustic radiation force impulse imaging elastography is efficacious in detecting hepatic fibrosis in children

Aliaga, Sara Desamparados Picó; Velilla, D. Muro; García-Martí, Gracián; Nebot, C. Sangüesa; Martí‐Bonmatí, Luis

doi:10.1016/j.rxeng.2014.04.008

Cited by 3 publications

(6 citation statements)

References 37 publications

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“…ARFI is as accurate as TE in predicting advanced fibrosis and cirrhosis . In children with chronic liver disease, ARFI accurately detected advanced fibrosis (AUROC, 0.98) but was less effective for mild fibrosis (AUROC, 0.8) . ARFI has been compared with posttransplant histology in 60 children to date.…”

Section: Detection Of Late Allograft Hepatitis and Fibrosismentioning

confidence: 99%

“…(42) In children with chronic liver disease, ARFI accurately detected advanced fibrosis (AUROC, 0.98) but was less effective for mild fibrosis (AUROC, 0.8). (49,50) ARFI has been compared with posttransplant histology in 60 children to date. Only significant fibrosis could be discriminated and acute cholestasis caused false positives.…”

Section: Acoustic Radiation Force Impulsementioning

confidence: 99%

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Late graft hepatitis and fibrosis in pediatric liver allograft recipients: Current concepts and future developments

et al. 2016

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Liver transplantation (LT) in children now has a 20-year survival of >80%, but the longterm outcome of these grafts remains uncertain. Serial protocol liver biopsies after transplantation from several pediatric centres have demonstrated the gradual development of unexplained graft inflammation ("idiopathic" posttransplant hepatitis; IPTH) and graft fibrosis in biopsies obtained >12 months post-LT in children with good graft function and (near) normal liver biochemistry. Although the clinical significance of these findings is uncertain, there is evidence to suggest that IPTH may be a form of rejection or chronic antibody-mediated rejection as it is associated with the presence of auto/alloantibodies; de novo Class II donor-specific HLA antibodies (DSA); previous episodes of rejection, and may improve or be prevented with increased immunosuppression. Currently, the only method of diagnosing either hepatitis or fibrosis has been by serial protocol biopsies as neither serum markers of fibrosis nor noninvasive methods to detect fibrosis such as transient elastography (TE) are sufficiently validated in children. This review will focus on the diagnosis and management of idiopathic posttransplant hepatitis and graft fibrosis, discuss current methods for detecting graft injury, and potential mechanisms for their development. Liver Transplantation 22 1593-1602 2016 AASLD.

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Section: Detection Of Late Allograft Hepatitis and Fibrosismentioning

confidence: 99%

Section: Acoustic Radiation Force Impulsementioning

confidence: 99%

Late graft hepatitis and fibrosis in pediatric liver allograft recipients: Current concepts and future developments

et al. 2016

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“…There are many studies that use the ARFI method for evaluating LF in adults (12–18). However, few studies have been performed with the ARFI technique to assess LF in children (19–22). The mean SWV in our study was 1.18 ± 0.28 m/s, which is close to the upper range of 1.07–1.19 m/s reported in children with a healthy liver (28–30).…”

Section: Discussionmentioning

confidence: 99%

“…There are a number of ARFI imaging studies of the liver in adults (12–18), especially for estimating the degree of LF. However, only a few published studies have evaluated liver fibrosis with ARFI in children (19–22), and they include healthy children and children with liver disease. To our knowledge, no studies have been reported in the literature on the ARFI technique for evaluation of the liver in obese children.…”

Section: Introductionmentioning

confidence: 99%

Acoustic radiation force impulse imaging for detection of liver fibrosis in overweight and obese children

et al. 2017

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Background Acoustic radiation force impulse (ARFI) is a non-invasive alternative to a liver biopsy for the evaluation of liver fibrosis (LF). Purpose To investigate the potential usefulness of acoustic radiation force impulse ARFI for detecting LF in overweight and obese children Material and Methods A cross-sectional study was conducted in 148 schoolchildren. A diagnosis of non-alcoholic fatty liver disease (NAFLD) and LF was based on ultrasound (US) and ARFI shear wave velocity (SWV). Results The laboratory parameters were normal in all the children. NAFLD was observed in 50 children (33.8%). The median SWV was 1.18 ± 0.28 m/s. Differences between ARFI categories and hepatic steatosis grades were observed (χ2 = 43.38, P = 0.0005). No fibrosis or insignificant fibrosis (SWV ≤ 1.60 m/s) was detected in 137 children (92.5%), and significant fibrosis (SWV > 1.60 m/s) in 11 children (7.5%), nine of whom had normal US or mild steatosis. Conclusion The present study is the first to evaluate the utility of the ARFI technique for detecting LF in overweight and obese children. The results of the study suggest that children with normal laboratory parameters such as normal liver ultrasound or mild steatosis may present with significant LF.

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“…Early stage steatosis does not cause serious problems, but cirrhosis can lead to progressive stages. In the pediatric age group, the causes of steatosis vary in a wide spectrum including metabolic diseases, nonalcoholic fatty liver diseases and obesity [1][2][3][4][5][6]. Although steatosis is considered reversible, it must be confirmed by biopsy depending on the effect.…”

Section: Introductionmentioning

confidence: 99%

Effects of fatty filtration at the pediatric liver hemodynamic changes evaluated by Doppler ultrasonography

Özkan¹

2019

Ortadogu Tıp Derg

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Background: Hemodynamic changes in liver vascular structures of patients in the pediatric age group are evaluated by doppler ultrasonography. Material: Fifty-nine hepatosteatosis patients, classified as mild, moderate or severe, and 23 healthy volunteers were included in this 82-person study. The height, weight, liver size tests of the subjects were measured. Those values were compared in the patient and control groups. In the patient and control groups, color duplex Doppler ultrasonography was used to examine portal vein peak velocity, portal vein flow volume, hepatic artery resistive index (RI), hepatic artery pulsatility index (PI) and hepatic artery flow volume. Results: Similar to the degree of hepatosteatosis, increases in body mass index, liver size were statistically significant (p<0.05). The difference between portal vein peak velocity hepatosteatosis and control groups was found statistically significant. As the hepatosteatosis grade increased, there was no statistically significant decrease in hepatic arterial flow volume, portal vein flow volume, and total flow volume. Hepatic artery RI and PI values were statistically significantly lower in the control group than the other groups (p <0.05). There was a significant mild decrease in the mild stool group compared to the middle steat group. Although the hepatic artery RI and PI values did not differ statistically in the comparison of the hepatosteatosis group, there was a minimal increase in the RI and PI values as the steatosis grade increased. Discussion: According to these results, as the level of steatosis increases, the changes in the portal venous structures become more prominent and the resistance increases in vascular structures.

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Acoustic radiation force impulse imaging elastography is efficacious in detecting hepatic fibrosis in children

Cited by 3 publications

References 37 publications

Late graft hepatitis and fibrosis in pediatric liver allograft recipients: Current concepts and future developments

Late graft hepatitis and fibrosis in pediatric liver allograft recipients: Current concepts and future developments

Acoustic radiation force impulse imaging for detection of liver fibrosis in overweight and obese children

Effects of fatty filtration at the pediatric liver hemodynamic changes evaluated by Doppler ultrasonography

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