Acoustic-responsive carbon dioxide-loaded liposomes for efficient drug release

Orita, Yasuhiko; Shimanuki, Susumu; Okada, Satoshi; Nakamura, Kentaro; Nakamura, Hiroyuki; Kitamoto, Yoshitaka; Shimoyama, Yusuke; Kurashina, Yuta

doi:10.1016/j.ultsonch.2023.106326

Cited by 11 publications

(3 citation statements)

References 51 publications

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“…There have been attempts at encapsulating or decorating particles or bubbles with drugs so that ultrasound can be used to release the drugs at a particular location, such as a cancer tumor. A recent work reporting supercritical carbon dioxide-formed liposomes produces a much more efficient release of drugs upon exposure to ultrasound than past microparticle-based approaches (Orita et al, 2023).…”

Section: Delivering Drugsmentioning

confidence: 99%

Acoustofluidics

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2023

Front. Acoust.

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The propagation of acoustic waves in fluids and solids produces fascinating phenomena that have been studied since the late 1700s and through to today, where it is finding broad application in manipulating fluids and particles at the micro to nano-scale. Due to the recent and rapid increase in application frequencies and reduction in the scale of devices to serve this new need, discrepancies between theory and reality have driven new discoveries in physics that are underpinning the burgeoning discipline. While many researchers are continuing to explore the use of acoustic waves in microfluidics, some are exploring vastly smaller scales, to nanofluidics and beyond. Because many of the applications incorporate biological material—organelles, cells, tissue, and organs—substantial effort is also being invested in understanding how ultrasound interacts with these materials. Surprisingly, there is ample evidence that ultrasound can be used to directly drive cellular responses, producing a new research direction beyond the established efforts in patterning and agglomerating cells to produce tissue. We consider all these aspects in this mini-review after a brief introduction to acoustofluidics as an emerging research discipline.

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Section: Delivering Drugsmentioning

confidence: 99%

Acoustofluidics

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2023

Front. Acoust.

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“…Drug delivery systems are recognized as efficient adjuvant therapy for bone tumors to avoid the strong side effects caused by conventional chemotherapy − and also to probe the tumor and surrounding area to obtain images for monitoring potential events associated. , Clinical studies have shown that nanomaterials loaded with antitumor drugs can circumvent the side effects caused by systemic administration to the greatest extent compared to free drugs. − These nanocarriers can improve drug permeability by sensing environmental stimuli (such as pH, temperature, magnetism, and ultrasound), enhancing the permeability retention effect, and lengthening circulation time to realize passive targeting. − …”

Section: Introductionmentioning

confidence: 99%

Titanium Carbide MXene Quantum Dots-Modified Hydroxyapatite Hollow Microspheres as pH/Near-Infrared Dual-Response Drug Carriers

Liu,

Pan,

Gan

et al. 2023

Langmuir

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Titanium carbide MXene quantum dots (MQDs) possess intrinsic regulatory properties and selective toxicity to cancer cells. Here, MDQs were selected for the modification of hydroxyapatite (HA) microspheres, and MXene quantum dots-modified hydroxyapatite (MQDs-HA) hollow microspheres with controllable shapes and sizes were prepared as bone drug carriers. The results show that the prepared MQDs-HA hollow microspheres had a large BET surface area (231.2 m 2 /g), good fluorescence, and low toxicity. In addition, MQDs-HA showed a mild storage−release behavior and good responsiveness of pH and near-infrared (NIR). Thus, the MQDs-HA hollow microspheres have broad application prospects in the field of drug delivery and photothermal therapy.

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“…41 But the original properties could deteriorate and the enzymatic character was inevitably impaired. As the best simulator of human cells, liposomes not only have an excellent biocompatibility, 42,43 but also can be attached to the surface via covalent linkages, specific bio-interactions, or simple physisorption. [44][45][46] It was proved that liposomes have a significant impact on the effect of peroxide-like enzymes, and the negatively charged liposomes could realize the oxidation of peroxidase mimic enzymes to TMB under neutral or even alkaline conditions.…”

Section: Introductionmentioning

confidence: 99%