Acoustic rhinometric assessment of nasal obstruction after treatment with fluticasone propionate in patients with perennial rhinitis

Chan, Kwai-Onn; Huang, Zhi‐Li; Wang, Deyun

doi:10.1016/s0385-8146(03)00085-3

Cited by 16 publications

(17 citation statements)

References 17 publications

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“…It has less potential for systemic adverse effects because it is very poorly absorbed in the gastrointestinal tract and is subject to extensive first-pass metabolism in the liver. Various studies have evaluated the efficacy of FP nasal spray and found it to be effective in the reduction of total nasal symptom score and total orbital symptom scores [7][8][9]. We used FP in our study and our results shows similar symptomatic efficacy for INS as studies in literature [7][8][9].…”

Section: Discussionsupporting

confidence: 52%

Nasal Breathing Exercise and its Effect on Symptoms of Allergic Rhinitis

Nair

2011

Indian J Otolaryngol Head Neck Surg

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Allergic rhinitis (AR) is a common and chronic health problem with a high prevalence and a significant effect on the health care expenditure. Intranasal steroid spray is recommended as the first line therapy for patients with moderate to severe AR. Our study clinically analysed the use of nasal breathing exercise (NBE) as an adjunct to intranasal steroid spray as a cheap and effective mode of management of AR. A 3 month, parallel, randomized study was carried out in a zonal and tertiary care referral center. In this study, participants (N = 60) with symptomatic AR were administered either a intranasal steroid spray fluticasone propionate (group A) or fluticasone propionate nasal spray and NBE (group B). Participants assessed their symptom severity daily over the 3 month treatment period. The mean total nasal symptom scores were lower in both the groups (5.1 vs. 3.8333 for group A and 5.2 vs. 2.6777 for group B) and the difference was statistically significant (P \ 0.05). The patients showed a definite improvement in overall and individual symptoms for both groups with significantly greater reduction in individual symptoms in the group B (P \ 0.05). In our study we have found that both treatments provided clinically meaningful responses, but the overall results favored fluticasone propionate and the NBE group. Hence NBE is a simple and cost effective measure to reduce symptoms of AR and improve patient satisfaction.

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Section: Discussionsupporting

confidence: 52%

Nasal Breathing Exercise and its Effect on Symptoms of Allergic Rhinitis

Nair

2011

Indian J Otolaryngol Head Neck Surg

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“…Although both study cohorts consisted of healthy adults, pertinent rhinologic comorbidities including allergies and chronic rhinosinusitis were unknown. The use of nasal steroids or other medications, which can influence measures of intranasal volumes in patients with rhinitis, was also unknown . The variability of intranasal anatomy and the resolution of the MRI did not allow for clear definition of the soft tissue and air boundaries on the template images.…”

Section: Discussionmentioning

confidence: 99%

“…The use of nasal steroids or other medications, which can influence measures of intranasal volumes in patients with rhinitis, was also unknown. 36 The variability of intranasal anatomy and the resolution of the MRI did not allow for clear definition of the soft tissue and air boundaries on the template images. Therefore, we included the entire nasal cavity in our voxelbased analyses.…”

Section: Discussionmentioning

confidence: 99%

Age‐related differences in olfactory cleft volume in adults: A computational volumetric study

et al. 2018

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Objectives/Hypothesis There is a growing need to understand the underlying mechanisms of age‐related olfactory dysfunction with the increasing proportion of older adults over the next 20 years. Despite the importance of olfactory cleft (OC) volumes on odorant deposition and olfactory function, little is known about age‐related changes to OC volume. The goal of this study was to use automated techniques in a cross‐sectional design to investigate the extent to which OC volumes vary with age and determine the spatial specificity of any age‐related effects. Study Design Retrospective cross‐sectional study. Methods Deformation‐based morphometry was utilized to measure OC and sinus volumes in two independent samples of 101 (Medical University of South Carolina [MUSC] sample) and 95 (Hammersmith sample) healthy adults who underwent T1‐weighted magnetic resonance imaging, with the Hammersmith sample serving as a replication sample. Results The mean age of the MUSC and Hammersmith samples were 54.9 ± 17.0 years and 52.1 years ± 15.7 years, respectively. In both samples, there was a significant positive association between age and OC volume that occurred at a constant rate across the lifespan (Cohen's f2 of 0.065 in the MUSC sample and 0.110 in the Hammersmith sample). Age‐associated OC volume increases occurred in conjunction with decreases in sinus volumes as well as increases in non‐OC nasal cavity volumes. Conclusions In this cross‐sectional study, there is an increase in OC volume with increasing age that occurs in the context of broad age‐associated differences in sinonasal anatomy. Future studies should investigate the impact of age‐associated differences in intranasal anatomy on nasal airflow, odorant deposition, and olfactory function. Level of Evidence 4 Laryngoscope, 129:E55–E60, 2019

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“…AR has many advantages, including reliability, ease of use, and the fact that it is noninvasive 9 . AR is a useful and objective tool in the diagnosis of nasal obstruction 10 and has also been proven a useful instrument in monitoring the effectiveness of medical therapy for PAR 11 . However, AR has some limitations, especially sound loss in the paranasal sinuses 2,12,13 …”

Section: Discussionmentioning

confidence: 99%

“…Despite maximum care to carry out the tests in the same way the repetitions may cause variations of the data of AR, and this might concern no correlation between AR and clinical findings. In addition, objective measurements of nasal patency do not always correlate with a patient's subjective sensation of nasal obstruction 11 …”

Section: Discussionmentioning

confidence: 99%