Acoustic spectroscopy of DNA in the gigahertz range

Abstract

We find a parametric resonance in the gigahertz range of DNA dynamics, generated by pumping hypersound. The resonance may be accompanied by the formation of localized phonon modes due to the random structure of elastic modulii of DNA.

How quantum entanglement in DNA synchronizes double-strand breakage by type II restriction endonucleases

“…Researchers have investigated vibrational modes in DNA from theoretical [24], computational [25], and experimental [26] perspectives. In the following sections, we describe our physical model for DNA sequences that unlike these past investigations exploits their electronic quantum vibrational modes, which impact the chemistry.…”

Mapping low frequency vibrational spectra of ssDNA using DNH optical trap

“…Optical tweezers have been used to determine the conformational flexibility at single molecule level using forceextension principle or fluorescence resonance energy transfer (FRET) [1,2]. The vibrational modes of DNA, on the other hand, have been well established for a wide range of frequencies ranging from far infra-red to submillimeter using the infrared spectroscopy, Raman spectroscopy, absorption spectroscopy [3,4]. However, the study of very low frequency modes using these techniques is not well established and requires further investigation [5].…”

Playing the notes of DNA with light: extremely high frequency nanomechanical oscillations

“…7 The elastic dynamics of DNA have been studied using Raman scattering, 8,9 Brillouin scattering, 10 far-infrared absorption, 11 and sub-millimeter wave absorption spectroscopy in the range of 0.01-10 THz. 12,13 The study of vibrational dynamics of DNA has resulted in various applications such as detecting mutations by identifying resonant modes associated with localized defect in the DNA polymer. 14 Most of these works have used double stranded DNA (dsDNA) and given insight into the dsDNA conformational flexibility and vibrational modes, while single stranded DNA (ssDNA) remains less studied.…”

“…Recently hypersound spectroscopy was used to study phonon modes of DNA in the range of 500 GHz and above. 13 But still these studies have been unable to show the lower frequency modes in the few tens of GHz range, in part due to the requirement of sufficiently thick and large diameter films and thus lack conclusive identification of these lower frequency modes. 12 Here we excite and measure the resonant vibrational modes of small ssDNA molecules (tens of bases) in the 10-100 GHz range using a DNH optical tweezer.…”