Acoustic tweezers using bisymmetric coherent surface acoustic waves for dynamic and reconfigurable manipulation of particle multimers

Pan, Hemin; Mei, Deqing; Xu, Chengyao; Li, Xin; Wang, Yancheng

doi:10.1016/j.jcis.2023.04.021

Cited by 6 publications

(4 citation statements)

References 36 publications

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“…It is believed that the proposed method can contribute to tissue engineering and regenerative medicine application. In the future, this method has the opportunity to further combine different patterning modes of the sound field (Figure S5A) to create functional vascular tissues of the specific shapes. , …”

Section: Discussionmentioning

confidence: 99%

“…The reported acoustofluidic engineering of vessel-on-a-chip not only inherited the advantages of previous acoustophoretic publications 81,96 but also incorporated technical points from the literature about hydraulic pressure activating vessel formation. 97,98 To demonstrate the function of the acoustofluidic engineered vascular structure, the perfusability and permeability of the vessel-on-a-chip was verified. Further, a molecular dynamic computational model was proposed to illustrate how the compound crosses the vascular lipid layer.…”

Section: ■ Conclusionmentioning

confidence: 99%

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Acoustofluidic Engineering of Functional Vessel-on-a-Chip

Wu,

Zhao,

Islam

et al. 2023

ACS Biomater. Sci. Eng.

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Construction of in vitro vascular models is of great significance to various biomedical research, such as pharmacokinetics and hemodynamics, and thus is an important direction in the tissue engineering field. In this work, a standing surface acoustic wave field was constructed to spatially arrange suspended endothelial cells into a designated acoustofluidic pattern. The cell patterning was maintained after the acoustic field was withdrawn within the solidified hydrogel. Then, interstitial flow was provided to activate vessel tube formation. In this way, a functional vessel network with specific vessel geometry was engineered on-chip. Vascular function, including perfusability and vascular barrier function, was characterized by microbead loading and dextran diffusion, respectively. A computational atomistic simulation model was proposed to illustrate how solutes cross the vascular membrane lipid bilayer. The reported acoustofluidic methodology is capable of facile and reproducible fabrication of the functional vessel network with specific geometry and high resolution. It is promising to facilitate the development of both fundamental research and regenerative therapy.

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Section: Discussionmentioning

confidence: 99%

Section: ■ Conclusionmentioning

confidence: 99%

Acoustofluidic Engineering of Functional Vessel-on-a-Chip

Wu,

Zhao,

Islam

et al. 2023

ACS Biomater. Sci. Eng.

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“…Acoustofluidic patterning, which capitalizes on stable standing wave fields in a discontinuous fluid environment, is gaining traction in regenerative medicine and biomedicine [82,83]. This technique can be likened to a microscale application of Faraday's classic Chladni plate experiment, exploiting the non-contact, remote manipulation capabilities of acoustofluidics to precisely position live cells without compromising their viability, thus making it exceptionally suitable for tissue engineering endeavors [84,85]. Based on the non-contact, remote manipulation and biocompatible characteristics of acoustofluidics on live cells, a stable standing wave field can relocate to a specific location without affecting the cell state, which makes it very suitable for tissue engineering-related projects [86].…”

Section: Acoustofluidic Patterning Of Living Cells For Tissue Enginee...mentioning

confidence: 99%

Acoustofluidic Actuation of Living Cells

Wu,

Gai,

Zhao

et al. 2024

Micromachines

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Acoutofluidics is an increasingly developing and maturing technical discipline. With the advantages of being label-free, non-contact, bio-friendly, high-resolution, and remote-controllable, it is very suitable for the operation of living cells. After decades of fundamental laboratory research, its technical principles have become increasingly clear, and its manufacturing technology has gradually become popularized. Presently, various imaginative applications continue to emerge and are constantly being improved. Here, we introduce the development of acoustofluidic actuation technology from the perspective of related manipulation applications on living cells. Among them, we focus on the main development directions such as acoustofluidic sorting, acoustofluidic tissue engineering, acoustofluidic microscopy, and acoustofluidic biophysical therapy. This review aims to provide a concise summary of the current state of research and bridge past developments with future directions, offering researchers a comprehensive overview and sparking innovation in the field.

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“…[28][29][30] In the field of acoustic manipulations, some of important progress have been made. [31][32][33] Recently, the influence of cavity and interface on ARF has been evaluated. [34][35][36] The concept of "acoustic tweezers" emphasizes the construction of acoustic potential wells for particle manipulation and trapping.…”

Section: Introductionmentioning

confidence: 99%

Scheme of negative acoustic radiation force based on a multiple-layered spherical structure

Gong 宫,

Xu 徐,

Qiao 乔

et al. 2024

Chinese Phys. B

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Acoustic radiation force(ARF), as an important particle manipulation method, has been extensively studied in recent years. With the introduction of the concept of “acoustic tweezers”, negative acoustic radiation has become a research hotspot. In this paper, a scheme of realizing negative ARF based on the multiple-layered spherical structure design is proposed. The specific structure and design idea are proposed. Detailed theoretical calculation analysis is carried out. Numerical simulations have been carried out to verify the correctness of this prediction. The conjecture that the suppression of backscattering can achieve negative ARF is verified concretely, which greatly expands the application prospect and design ideas of the ARF. This work has laid a theoretical foundation for realizing precise control of the structure.

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Acoustic tweezers using bisymmetric coherent surface acoustic waves for dynamic and reconfigurable manipulation of particle multimers

Cited by 6 publications

References 36 publications

Acoustofluidic Engineering of Functional Vessel-on-a-Chip

Acoustofluidic Engineering of Functional Vessel-on-a-Chip

Acoustofluidic Actuation of Living Cells

Scheme of negative acoustic radiation force based on a multiple-layered spherical structure

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