Acoustic voice analysis in patients with essential tremor

Gamboa, Javier; Jiménez‐Jiménez, Félix Javier; A, Nieto; Cobeta, Ignacio; Vegas, Alberto; Ortı́-Pareja, M; Gasalla, Teresa; Molina, José Antonio; E, García-Albea

doi:10.1016/s0892-1997(98)80053-2

Cited by 62 publications

(36 citation statements)

References 17 publications

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“…The syllable repetition impairment in the ET patients was not due to voice tremor, as prolonged syllable duration was also found in ET patients without voice tremor. This finding is comparable to a study in which an acoustic voice analysis of a sustained /a/ and a spoken sentence was performed in ET patients compared with controls [51]. ET patients showed higher jitter, lower harmonics-to-noise ration, and a lower dynamic range at the natural frequency of phonation, irrespective of the presence of voice tremor.…”

Section: Discussionsupporting

confidence: 81%

Balance and Motor Speech Impairment in Essential Tremor

et al. 2009

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The pathogenesis of essential tremor (ET) is still under debate. Several lines of evidence indicate that ET is associated with cerebellar dysfunction. The aim of the present study was to find corroborating evidence for this claim by investigating balance and speech impairments in patients with ET. In addition, the effect of deep brain stimulation (DBS) on balance and speech function was studied. A group of 25 ET patients including 18 with postural and/or simple kinetic tremor (ETpt) and seven ET patients with additional clinical signs of cerebellar dysfunction (ETc) was compared to 25 healthy controls. In addition, 12 ET patients with thalamic DBS participated in the study. Balance control was assessed during gait and stance including tandem gait performed on a treadmill as well as static and dynamic posturography. Motor speech control was analyzed through syllable repetition tasks. Signs of balance impairment were found in early stages and advanced stages of ET. During locomotion, ET patients exhibited an increased number of missteps and shortened stride length with tandem gait. ETc patients and, to a lesser extent, ETpt patients had increased postural instability in dynamic posturography conditions that are sensitive to vestibular or vestibulocerebellar dysfunction. ETc but not ETpt patients exhibited significantly increased syllable durations. DBS had no discernable effect on speech performance or balance control. We conclude that the deficits in balance as well as the subclinical signs of dysarthria in a subset of patients confirm and extend previous findings that ET is associated with an impairment of the cerebellum.

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Section: Discussionsupporting

confidence: 81%

Balance and Motor Speech Impairment in Essential Tremor

et al. 2009

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“…The fact that vocal tremor is more related to modulation extents than to modulation rates is consistent with results indicating that the severity of tremor is correlated with acoustic measures of amplitude and frequency perturbations [11]. This is due to perturbation measures such as jitter or shimmer not including information on the autocorrelation properties of the varying magnitude; i.e.…”

Section: Introductionsupporting

confidence: 86%

Simulation of tremulous voices using a biomechanical model

Fraile

Godino-Llorente

Kob

2015

J AUDIO SPEECH MUSIC PROC.

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Vocal tremor has been simulated using a high-dimensional discrete vocal fold model. Specifically, respiratory, phonatory, and articulatory tremors have been modeled as instabilities in six parameters of the model. Reported results are consistent with previous knowledge in that respiratory tremor mainly causes amplitude modulation of the voice signal while laryngeal tremor causes both amplitude and frequency modulation. In turn, articulatory tremor is commonly assumed to produce only amplitude modulations but the simulation results indicate that it also produces a high-frequency modulation of the output signal. Furthermore, articulatory tremor affects the frequency response of the vocal tract and it might thus be detected by analyzing the spectral envelope of the acoustic signal.

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“…The increased irregularity of syllable repetition in the ALS subjects is in contrast to reports that rate of repetition is slow but regularity of repetition is preserved. 22 Intensity levels during ddk repetitions were mildly reduced for all three subject groups, with significantly increased variability in the loudness level of each syllable for the ALS and Tremor groups.…”

Section: Discussionmentioning

confidence: 89%